The Role of Hepatic Insulin Clearance in Obesity and Type 2 Diabetes

Dear Colleagues,

The global prevalence of obesity and type 2 diabetes is rising at an alarming rate. Over the past decade, studies have demonstrated the significant role of insulin clearance in the obesity and pathogenesis of type 2 diabetes. It is well established that diminished hepatic insulin clearance leads to an elevated secretion of insulin into the systemic circulation, consequently resulting in hyperinsulinemia. Prolonged hyperinsulinemia can further exacerbate beta cell function, ultimately promoting type 2 diabetes. Nevertheless, the precise mechanisms and the role of insulin clearance in the obesity and pathogenesis of type 2 diabetes remain elusive.

This Special Issue aims to present recent data related to and insights into the role of insulin clearance in obesity and the pathogenesis of type 2 diabetes. The scope extends to investigations in animal models as well as human subjects, plus new methods measuring lipidomics, metabolomics, or biomarkers capable of identifying changes caused by reduced or enhanced insulin clearance. Overall, the objective is to offer a comprehensive exploration of this critical element of study.

Dr. Morvarid Kabir
Dr. Richard N. Bergman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• insulin clearance
• insulin resistance
• type 2 diabetes
• obesity
• hyperinsulinemia