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Non-drug Therapies and Their Metabolic Effects in Non-communicable Diseases

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A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 4889

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Special Issue Editors

Dr. Rodica Ana Ungur

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Guest Editor

Department of Medical Specialties, Faculty of Medicine, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Interests: oxidative stress; inflammation; osteoarthritis; osteoporosis; bone fractures; physical medicine and rehabilitation; ultrasound therapy; laser therapy; non-steroidal anti-inflammatory drugs; kidney injuries; nano-polyoxometalates; plants extracts

Dr. Ileana Monica Borda

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Department of Medical Specialties, Faculty of Medicine, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 8 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Interests: musculoskeletal disorders; sport injuries; osteoarthritis; osteoporosis; non-steroidal anti-inflammatory drugs; oxidative stress; ultrasound examination of the musculoskeletal system; rehabilitation; physical therapy

Dr. Georgiana Smaranda Martis

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Guest Editor

Food Engineering Department, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 64 Calea Floresti, 400509 Cluj-Napoca, Romania
Interests: bioactive compounds; food science; oxidative stress; antioxidants; medicinal plants and herbs

Prof. Dr. Young Hae Choi

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Guest Editor

Natural Products Laboratory, Institute of Biology, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands
Interests: metabolomics; phytochemistry; supercritical fluid extraction; natural deep eutectic solvents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic pathways and their correction need urgent and thorough evaluation to elucidate their role in non-communicable diseases (NCDs). Notably, natural compounds (plants, nutrients, mineral water, therapeutic mud) and physical therapy have been shown to have anti-inflammatory, anti-oxidative and regenerative effects. Nevertheless, their complete metabolic effects are still insufficiently elucidated in relation to the evolution of metabolites and metabolic pathways in NCDs. This Special Issue is dedicated to the study of metabolic effects produced by natural compounds, physical therapy, and environmental factors in NCDs. We also aim to highlight the regenerative effects of tissue as a consequence of correcting metabolic pathways.

Topics:

Analysis of metabolite(s) in NCDs;
Analysis of the metabolic effects of plants, nutrients, environmental factors, therapeutic mud, mineral water, and physical agents on the metabolism and metabolic pathways in NCDs;
Methodology development for detecting metabolites or changes in metabolic pathways in NCDs
Metabolic pathways, networks, diseases, and errors in metabolism in NCDs;
Metabolic pathways of autophagy in non-communicable diseases.

Dr. Rodica Ana Ungur
Dr. Ileana Monica Borda
Dr. Georgiana Smaranda Martis
Prof. Dr. Young Hae Choi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

non-communicable disease
oxidative stress
inflammation
methabolomics
antioxidants
plants
nutrients
mineral waters
therapeutic mud
physical exercise
physical agents

Published Papers (2 papers)

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Research

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29 pages, 5761 KiB

Open AccessArticle

Erythroprotective Potential of Phycobiliproteins Extracted from Porphyridium cruentum

by Rubria Lucía Peña-Medina, Diana Fimbres-Olivarría, Luis Fernando Enríquez-Ocaña, Luis Rafael Martínez-Córdova, Carmen Lizette Del-Toro-Sánchez, José Antonio López-Elías and Ricardo Iván González-Vega

Metabolites 2023, 13(3), 366; https://doi.org/10.3390/metabo13030366 - 01 Mar 2023

Cited by 7 | Viewed by 1867

Abstract

There are multiple associations between the different blood groups (ABO and RhD) and the incidence of oxidative stress-related diseases, such as certain carcinomas and COVID-19. Bioactive compounds represent an alternative to its prevention and treatment. Phycobiliproteins (PBP) are bioactive compounds present in the microalga Porphyridium cruentum and, despite its antioxidant activity, their inhibitory effect on hemolysis has not been reported. The aim of this work was to evaluate the erythroprotective potential of phycobiliproteins from P. cruentum in different blood groups. The microalga was cultured in F/2 medium under controlled laboratory conditions. Day 10 of culture was determined as the harvest point. The microalgal biomass was lyophilized and a methanolic (MetOH), Tris HCl (T-HCl), and a physiological solution (PS) ultrasound-assisted extraction were performed. Extract pigments were quantified by spectrophotometry. The antioxidant activity of the extracts was evaluated with the ABTS^+•, DPPH^•, and FRAP methods, finding that the main antioxidant mechanism on the aqueous extracts was HAT (hydrogen atom transfer), while for MetOH it was SET (single electron transfer). The results of the AAPH, hypotonicity, and heat-induced hemolysis revealed a probable relationship between the different antigens (ABO and RhD) with the antihemolytic effect, highlighting the importance of bio-directed drugs. Full article

(This article belongs to the Special Issue Non-drug Therapies and Their Metabolic Effects in Non-communicable Diseases)

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Review

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15 pages, 602 KiB

Open AccessReview

Effectiveness of Intermittent Hypoxia–Hyperoxia Therapy in Different Pathologies with Possible Metabolic Implications

by Andreea-Bianca Uzun, Mădălina Gabriela Iliescu, Liliana-Elena Stanciu, Elena-Valentina Ionescu, Rodica Ana Ungur, Viorela Mihaela Ciortea, Laszlo Irsay, Irina Motoașcă, Marius Nicolae Popescu, Florina Ligia Popa, Loredana Pazara and Doina-Ecaterina Tofolean

Metabolites 2023, 13(2), 181; https://doi.org/10.3390/metabo13020181 - 25 Jan 2023

Cited by 7 | Viewed by 2258

Abstract

Intermittent oxygen therapy (IHT), initially used in the hypoxic administration variant, has been shown to be effective in various pathologies studied, from cardiopulmonary to vascular and metabolic pathologies and more. IHT used to prevent and treat various diseases has thus gained more and more attention as the years have passed. The mechanisms underlying the beneficial effects have been investigated at multiple biological levels, from systemic physiological reactions to genomic regulation. In the last decade, a new method of intermittent oxygen therapy has been developed that combines hypoxic and hyperoxic periods. They can be applied both at rest and during physical exercise, hence the specific indications in sports medicine. It has been hypothesized that replacing normoxia with moderate hyperoxia may increase the adaptive response to the intermittent hypoxic stimulus by upregulating reactive oxygen species and hypoxia-inducible genes. This systematic literature review is based on the “Preferred Reporting Items for Systematic Reviews and Meta-Analysis”—“PRISMA”—methodology, the widely internationally accepted method. Full article

(This article belongs to the Special Issue Non-drug Therapies and Their Metabolic Effects in Non-communicable Diseases)

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