Metabolomics-Based Biomarkers for Nutrition and Health

Dear Colleagues,

This Special Issue of Metabolites focuses on methodology and applied research in the area of metabolomics-based biomarker discovery, evaluation, validation and application for nutrition and health.

With technological advancement, various types of high-dimensional objective measurements such as metabolomics data provide great opportunities to develop biomarkers for nutrition and health outcomes. Recent developments in the area showed the usefulness of metabolomics as biomarkers for dietary intake for various macronutrients and helped study the association between dietary intakes and disease outcomes. Additionally, studies showed that metabolites can be used as biomarkers for an early detection of diseases and predict the risk of developing future diseases. However, there are many remaining gaps to be filled. The high dimensionality of these novel metabolomics data combined with their own measurement uncertainty present noteworthy challenges for statistical analysis in biomarker discovery. The potential heterogeneity in metabolomics platforms and technical variation between labs raised the question of the reliability, reproducibility and generalizability of developed metabolite-based biomarkers. Additional topics to be addressed include incorporating biological metabolomics pathway information and finding interpretable biomarkers, integrating multiple metabolomics data with other measurements and personal characteristics in predicting nutrition and disease status.

We hope that this Special Issue will provide a platform for researchers from various disciplines to share their latest findings, discuss emerging challenges and propose novel solutions. We welcome submissions that cover a wide range of topics, including, but not limited to:

• Development of a metabolomics-based biomarkers for nutrition and/or health-related outcomes;
• Validation and/or integration of developed metabolomics-based biomarkers;
• Utilization of metabolomics-based biomarkers for association studies relating nutrition and health;
• Early diagnosis of disease and prediction of intervention/treatment response utilizing metabolomics data.

Dr. Cheng Zheng
Prof. Dr. Daniel Raftery
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• biomarker
• metabolomics
• nutritional epidemiology
• disease diagnostics and prevention
• risk prediction