Electrochemical (Bio)sensors for Detection of Clinical Markers

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "C:Chemistry".

Deadline for manuscript submissions: closed (29 February 2020) | Viewed by 15940

Special Issue Editor


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Guest Editor
Departamento de Química Analítica, Facultad de CC. Químicas, Universidad Complutense de Madrid, Ciudad Universitaria, E-28040 Madrid, Spain
Interests: analytical chemistry; electroanalysis; (bio)sensors; point-of-care systems; multiplexing; miniaturization; automation; clinical, environmental, and food analysis

Special Issue Information

Dear Colleagues,

Modern society is in urgent need of efficient systems to perform routine screening in the prognosis and diagnosis of every disease, but mainly those affecting a great majority of the world population, i.e., cardiovascular diseases, cancer, and degenerative illnesses. The establishment of sustainable healthcare systems implies developing new sensing technologies for patient care covering features such as reliable, fast, inexpensive, quantitative, and easy-to-use systems ensuing decentralized medical care, one of the main objectives of health care organizations.

Bearing in mind the very promising potential of electrochemical sensors in this field, this Special Issue seeks to showcase research papers, short communications, and review articles displaying up-to-date research on novel advances in the field of electrochemical (bio)sensors for clinical markers with improved unique properties leading to highly reliable, stable, fast, low-cost, quantitative, and convenient methodologies. It also aims to show breakthroughs in microfabrication and microfluidic techniques coupled to electrochemical sensors, and the development of novel affordable materials and electronics to facilitate the production of small, portable, and cheap sensors for the determination of this kind of markers as part of routine medical examination, pursuing highly stable biosensing screening systems for continuous on-body determination or in vivo monitoring in a variety of body fluids towards the establishment of highly demanded preventive action and safe therapies.

Prof. Dr. María Pedrero
Guest Editor

Manuscript Submission Information

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Keywords

  • electrochemical
  • (bio)sensors
  • clinical markers
  • DNA
  • RNA
  • protein
  • cell
  • medical screening
  • body fluids
  • reliable detection
  • rapid determination
  • multiplexed systems
  • miniaturization
  • point-of-care testing

Published Papers (2 papers)

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Review

46 pages, 7737 KiB  
Review
Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers
by Jennifer Quinchia, Danilo Echeverri, Andrés Felipe Cruz-Pacheco, María Elena Maldonado and Jahir Orozco
Micromachines 2020, 11(4), 411; https://doi.org/10.3390/mi11040411 - 14 Apr 2020
Cited by 47 | Viewed by 6400
Abstract
The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers [...] Read more.
The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers at different stages of the disease can lead to an appropriate and instantaneous therapeutic action. In this context, the determination of biomarkers by electrochemical biosensors is at the forefront of cancer diagnosis research because of their unique features such as their versatility, fast response, accurate quantification, and amenability for multiplexing and miniaturization. In this review, after briefly discussing the relevant aspects and current challenges in the determination of colorectal tumor markers, it will critically summarize the development of electrochemical biosensors to date to this aim, highlighting the enormous potential of these devices to be incorporated into the clinical practice. Finally, it will focus on the remaining challenges and opportunities to bring electrochemical biosensors to the point-of-care testing. Full article
(This article belongs to the Special Issue Electrochemical (Bio)sensors for Detection of Clinical Markers)
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19 pages, 51852 KiB  
Review
Graphene-Based Biosensors for Detection of Biomarkers
by Yunlong Bai, Tailin Xu and Xueji Zhang
Micromachines 2020, 11(1), 60; https://doi.org/10.3390/mi11010060 - 03 Jan 2020
Cited by 127 | Viewed by 9236
Abstract
The development of biosensors with high sensitivity and low-detection limits provides a new direction for medical and personal care. Graphene and graphene derivatives have been used to prepare various types of biosensors due to their excellent sensing performance (e.g., high specific surface area, [...] Read more.
The development of biosensors with high sensitivity and low-detection limits provides a new direction for medical and personal care. Graphene and graphene derivatives have been used to prepare various types of biosensors due to their excellent sensing performance (e.g., high specific surface area, extraordinary electronic properties, electron transport capabilities and ultrahigh flexibility). This perspective review focuses on graphene-based biosensors for quantitative detection of cancer-related biomarkers such as DNA, miRNA, small molecules and proteins by integrating with different signal outputting approaches including fluorescent, electrochemistry, surface plasmon resonance, surface enhanced Raman scattering, etc. The article also discussed their challenges and potential solutions along with future prospects. Full article
(This article belongs to the Special Issue Electrochemical (Bio)sensors for Detection of Clinical Markers)
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