Microfluidic High-Throughput Single-Cell Analysis
A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 378
Special Issue Editor
2. Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA
3. CMU-Pitt Ph.D. Program in Computational Biology, Pittsburgh, PA 15213, USA
4. Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15260, USA
Interests: single-cell analysis; cancer precision medicine; microfluidics; machine learning; gene sequencing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular heterogeneity is a hallmark of multicellular life, giving forms and functions to organisms by facilitating specialization. With such ubiquity, it is of no wonder that this heterogeneity controls the physiology and pathogenesis of many diseases. Despite the known cellular heterogeneity, it is still common to use population-scale bulk analysis, masking the subsets of cells critical for biological discoveries and clinical decisions. As compared to bulk analysis. single-cell analysis, which analyzes the properties of individual cells, is the key to deciphering heterogeneous attributes in cell populations. Microfluidic technology has emerged as a state-of-the-art approach for single-cell analysis because of its precise micro-environment manipulation, minimal reagent usage, and high potential in scaling and automation. Its capability to control fluids in the range of nanoliters to picoliters can not only precisely isolate individual cells inside each chamber at single-cell resolution but also achieve high sensitivity of chemical sensing from a small amount of cellular contents. Accordingly, this Special Issue seeks to collect research papers and review articles that focus on but are not limited to novel microfluidic single-cell analysis, micro-manufacturing methods, high-throughput experimentation, and automation of single-cell assays.
Prof. Dr. Yu-Chih Chen
Guest Editor
Manuscript Submission Information
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Keywords
- Microfluidics
- Single-cell analysis
- Lab-on-a-chip
- High-throughput screening
- Micro-manufacturing
