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Micromachines
Special Issues
Optics Integrated Microfluidic Platforms for Diagnostic Applications
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Optics Integrated Microfluidic Platforms for Diagnostic Applications

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "A：Physics".

Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 5060

Special Issue Editors

Prof. Dr. Jiandong Wu

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Guest Editor
Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Interests: microfluidics; cell migration; biosensor; lab on a chip
Prof. Dr. Bo Dai

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Guest Editor
Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China
Interests: biomedical imaging; optofluidics; micro-fabrication
Prof. Dr. Dawei Zhang

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Guest Editor
Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, China
Interests: photoelectronic information; nano-optics; optical thin films
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Francis Lin

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Guest Editor
Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
Interests: microfluidic devices; cell migration; biomedical diagnostic assays; organ-on-chip models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics is known to be an enabling technology in a wide range of fields, particularly the chemical and biological sensing fields. Together with the development of technology, the integration of optics into microfluidic devices has enabled new directions of research and applications. As an example, owing to unique advantages in flow manipulation and sensitive signal detection, various optofluidic platforms have been developed to detect a wide range of disease-related biomarkers. Similarly, microfluidic devices integrated with portable imaging systems are increasingly being reported for various biomedical diagnostic applications. Through this Special Issue, we aim to highlight the development of optics-integrated microfluidic platforms and their diagnostic applications. Original research papers and review articles on the topics described above are welcome.

Prof. Dr. Jiandong Wu
Prof. Dr. Bo Dai
Prof. Dr. Dawei Zhang
Prof. Dr. Francis Lin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • optofluidics
  • lab-on-a-chip
  • diagnostic applications
  • biosensors

Published Papers (1 paper)

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Review

25 pages, 21604 KiB  
Review
Integrated Microfluidic-Based Platforms for On-Site Detection and Quantification of Infectious Pathogens: Towards On-Site Medical Translation of SARS-CoV-2 Diagnostic Platforms
by Andres Escobar, Phyllis Chiu, Jianxi Qu, Yushan Zhang and Chang-qing Xu
Micromachines 2021, 12(9), 1079; https://doi.org/10.3390/mi12091079 - 07 Sep 2021
Cited by 11 | Viewed by 4077
Abstract
The rapid detection and quantification of infectious pathogens is an essential component to the control of potentially lethal outbreaks among human populations worldwide. Several of these highly infectious pathogens, such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome coronavirus 2 [...] Read more.
The rapid detection and quantification of infectious pathogens is an essential component to the control of potentially lethal outbreaks among human populations worldwide. Several of these highly infectious pathogens, such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been cemented in human history as causing epidemics or pandemics due to their lethality and contagiousness. SARS-CoV-2 is an example of these highly infectious pathogens that have recently become one of the leading causes of globally reported deaths, creating one of the worst economic downturns and health crises in the last century. As a result, the necessity for highly accurate and increasingly rapid on-site diagnostic platforms for highly infectious pathogens, such as SARS-CoV-2, has grown dramatically over the last two years. Current conventional non-microfluidic diagnostic techniques have limitations in their effectiveness as on-site devices due to their large turnaround times, operational costs and the need for laboratory equipment. In this review, we first present criteria, both novel and previously determined, as a foundation for the development of effective and viable on-site microfluidic diagnostic platforms for several notable pathogens, including SARS-CoV-2. This list of criteria includes standards that were set out by the WHO, as well as our own “seven pillars” for effective microfluidic integration. We then evaluate the use of microfluidic integration to improve upon currently, and previously, existing platforms for the detection of infectious pathogens. Finally, we discuss a stage-wise means to translate our findings into a fundamental framework towards the development of more effective on-site SARS-CoV-2 microfluidic-integrated platforms that may facilitate future pandemic diagnostic and research endeavors. Through microfluidic integration, many limitations in currently existing infectious pathogen diagnostic platforms can be eliminated or improved upon. Full article
(This article belongs to the Special Issue Optics Integrated Microfluidic Platforms for Diagnostic Applications)
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