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Marine Natural Products: Isolations, Structures and Bioactivities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1198

Special Issue Editor

School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Interests: configuration; chiral; chromatography; molecular computerize
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural medicinal chemistry is a traditional discipline which aims to apply the principles of spectroscopy and medicine, explore natural resources, discover functional molecules that can effectively solve the problems of human survival and development, and reveal the general laws of natural evolution and development from the perspective of functional molecules. It is a discipline full of natural mysteries, enjoying the exploration of winding paths and scientific thinking of transforming feathers. Low-quality (MW<1000) functional molecules are the main research objects of natural medicinal chemistry, with extremely rich structural diversity and functional specificity, containing profound scientific problems and broad research and development prospects. The ocean contains enormous amounts of biological resources, and in-depth research on these resources is important for sustainable human development in the future. Coral reef ecosystems are extremely rich in species diversity and habitat particularity, especially reef-dwelling invertebrate sponges and corals. Like other organisms, their chemical defense phenomenon based on 

functional molecules provides important scientific enlightenment for the research and development of modern marine natural drugs. The deep exploration of this resource constitutes an important scientific axis in the multidimensional research on marine drugs. Its core is the exploration of specific chemical structural molecules, following the principle of unity in natural addition.

This Special Issue aims to publish high-quality research on various structures and diverse bioactivity.

Dr. Pinglin Li
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • structure identification
  • configuration study
  • flexible molecular
  • bioactivity essay method

Published Papers (1 paper)

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Research

16 pages, 6431 KiB  
Article
Theoretical and Experimental Studies on the Evidence of 1,3-β-Glucan in Marennine of Haslea ostrearia
by Muhammad Yusuf, Umi Baroroh, Rina Fajri Nuwarda, Fiddy Semba Prasetiya, Safri Ishmayana, Mia Tria Novianti, Taufik Ramdani Tohari, Ari Hardianto, Toto Subroto, Jean-Luc Mouget and Pamela Pasetto
Molecules 2023, 28(15), 5625; https://doi.org/10.3390/molecules28155625 - 25 Jul 2023
Cited by 2 | Viewed by 994
Abstract
Marennine, a blue pigment produced by the blue diatom Haslea ostrearia, is known to have some biological activities. This pigment is responsible for the greening of oysters on the West Coast of France. Other new species of blue diatom, H. karadagensis, [...] Read more.
Marennine, a blue pigment produced by the blue diatom Haslea ostrearia, is known to have some biological activities. This pigment is responsible for the greening of oysters on the West Coast of France. Other new species of blue diatom, H. karadagensis, H. silbo sp. inedit., H. provincialis sp. inedit, and H. nusantara, also produce marennine-like pigments with similar biological activities. Aside from being a potential source of natural blue pigments, H. ostrearia-like diatoms present a commercial potential for the aquaculture, food, cosmetics, and health industries. Unfortunately, for a hundred years, the exact molecular structure of this bioactive compound has remained a mystery. A lot of hypotheses regarding the chemical structure of marennine have been proposed. The recent discovery of this structure revealed that it is a macromolecule, mainly carbohydrates, with a complex composition. In this study, some glycoside hydrolases were used to digest marennine, and the products were further analyzed using nuclear magnetic resonance (NMR) and mass spectroscopy (MS). The reducing sugar assay showed that marennine was hydrolyzed only by endo-1,3-β-glucanase. Further insight into the structure of marennine was provided by the spectrum of 1H NMR, MS, a colorimetric assay, and a computational study, which suggest that the chemical structure of marennine contains 1,3-β-glucan. Full article
(This article belongs to the Special Issue Marine Natural Products: Isolations, Structures and Bioactivities)
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