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Synthesis, Characterization and Reactivity of Coordination Complexes and Organometallic Compounds

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1528

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Special Issue Editor

Prof. Dr. Zilu Chen

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Guest Editor

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
Interests: single-molecule magnets; anticancer; catalysis; cluster; complex; luminescence

Special Issue Information

Dear Colleagues,

We invite you to read or submit papers for this Special Issue. Coordination complexes and organometallic compounds have undergone rapid development in recent decades due to their interesting properties and wide applications in fields such as fluorescence, batteries, molecular magnetism, catalysis, bioactivity, adsorption, and separation. Some of them have vacant sites or labile ligands, which can act as highly efficient catalysts or readily undergo further reactions to assemble into new types of complexes with aesthetic structures and/or amazing properties. Another fascinating finding is that some coordination complexes and organometallic compounds can undergo post-modification to improve their performances or to endow new properties. We hope to record all of these interesting findings in this Special Issue, which welcomes recent research works and reviews in the above-mentioned areas.

Prof. Dr. Zilu Chen
Guest Editor

Manuscript Submission Information

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Keywords

coordination complex
organometallic compound
reactivity
post-modification
structure
performance
vacant site
labile ligand
property

Published Papers (2 papers)

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Research

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12 pages, 1967 KiB

Open AccessArticle

Regioselective C(sp²)-C(sp³) Coupling Mediated by Classical and Rollover Cyclometalation

by Lorenzo Manca, Giacomo Senzacqua, Sergio Stoccoro and Antonio Zucca

Molecules 2024, 29(3), 707; https://doi.org/10.3390/molecules29030707 - 03 Feb 2024

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Abstract

By taking advantage of a sequence of oxidative addition/reductive elimination reactions, Pt(II) cyclometalated derivatives are able to promote a rare C(sp²)-C(sp³) bond coupling, resulting in the production of novel methyl-substituted pyridines and bipyridines. Starting from 6-phenyl-2,2′-bipyridine, the step-by-step full sequence of reactions has been followed, leading to the unprecedented 3-methyl-6-phenyl-2,2′-bipyridine, which was isolated and fully characterized. The synthesis involves the following steps: (1) rollover cyclometalation to give the starting complex [Pt(N^C)(DMSO)Me]; (2) the synthesis of a more electron-rich complex [Pt(N^C)(PPh₃)Me] by the substitution of DMSO with triphenylphosphine; (3) oxidative addition with methyl iodide to give the Pt(IV) complex [Pt(N^C)(PPh₃)(Me)₂(I)]; (4) iodide abstraction with silver tetrafluoborate to give an unstable pentacoordinate intermediate, which rapidly evolves through a carbon–carbon reductive coupling, forming a new C(sp³)-C(sp²) bond; (5) finally, the extrusion and characterization of the newly formed 3-methyl-6-phenyl-2,2′-bipyridine. The reaction has been therefore extended to a well-known classical cyclometalating ligand, 2-phenylpyridine, demonstrating that the method is not restricted to rollover derivatives. Following the same step-by-step procedure, 2-phenylpyridine was converted to 2-o-tolyl-pyridine, displaying the potential application of the method to the larger family of classical cyclometalated complexes. The application of this protocol may be useful to convert an array of heterocyclic compounds to their methyl- or alkyl-substituted analogs. Full article

(This article belongs to the Special Issue Synthesis, Characterization and Reactivity of Coordination Complexes and Organometallic Compounds)

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Review

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20 pages, 2709 KiB

Open AccessReview

Review on the Applications of Selected Metal-Based Complexes on Infectious Diseases

by Nondumiso P. Dube, Maxwell Thatyana, Ntebogeng S. Mokgalaka-Fleischmann, Ahmed M. Mansour, Vuyelwa J. Tembu and Amanda-Lee E. Manicum

Molecules 2024, 29(2), 406; https://doi.org/10.3390/molecules29020406 - 14 Jan 2024

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Abstract

Fatalities caused by infectious diseases (i.e., diseases caused by parasite, bacteria, and viruses) have become reinstated as a major public health threat globally. Factors such as antimicrobial resistance and viral complications are the key contributors to the death numbers. As a result, new compounds with structural diversity classes are critical for controlling the virulence of pathogens that are multi-drug resistant. Derivatization of bio-active organic molecules with organometallic synthons is a promising strategy for modifying the inherent and enhanced properties of biomolecules. Due to their redox chemistry, bioactivity, and structural diversity, organometallic moieties make excellent candidates for lead structures in drug development. Furthermore, organometallic compounds open an array of potential in therapy that existing organic molecules lack, i.e., their ability to fulfill drug availability and resolve the frequent succumbing of organic molecules to drug resistance. Additionally, metal complexes have the potential towards metal-specific modes of action, preventing bacteria from developing resistance mechanisms. This review’s main contribution is to provide a thorough account of the biological efficacy (in vitro and in vitro) of metal-based complexes against infectious diseases. This resource can also be utilized in conjunction with corresponding journals on metal-based complexes investigated against infectious diseases. Full article

(This article belongs to the Special Issue Synthesis, Characterization and Reactivity of Coordination Complexes and Organometallic Compounds)

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