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Nanometer-Size Glyconanoparticles: Synthesis and Biomedical Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 March 2018) | Viewed by 5868

Special Issue Editor


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Guest Editor
Department of Chemistry, Université du Quebéc à Montréal, P.O. Box 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada
Interests: carbohydrate chemistry; vaccines; dendrimers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbohydrates and their conjugates constitute key biomolecular entities at the origin of a plethora of cellular communications. As such, they represent a family of naturally-encoded structures, now generally placed under the blanket term “glycocodes”. In natural settings, these roles are fulfilled by glycolipids, glycoproteins, and polysaccharides, which serve as interfacial ligands between them and their cognate protein receptors. Consequently, the interplay of such inter- and intra-molecular interactions, which are often multivalent, has triggered the design of novel molecular “glyco”architectures to better decipher their key biological functions. Synthetic nanomolecular materials have paved the way toward our deepening of mechanisms underlying these complex interactions. This Special Issue is dedicated to the description and recent synthetic strategies regarding novel nanomolecular carbohydrate-based architectures and their applications in therapeutic applications, such as glycohydrolases and bacterial/viral adhesion inhibitors, imaging, targeting, microarrays, and vaccines.

Prof. Dr. René Roy
Guest Editor

Manuscript Submission Information

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Keywords

  • carbohydrates
  • nanoparticles
  • QDots
  • gold NPs
  • dendrimers
  • fullerenes
  • SWNTs
  • polymersomes
  • liposomes
  • micelles
  • self-assembling
  • antibacterial, viral, cancer
  • vaccines

Published Papers (1 paper)

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Review

25 pages, 7462 KiB  
Review
Recent Advances in the Chemistry of Glycoconjugate Amphiphiles
by Laurent Latxague, Alexandra Gaubert and Philippe Barthélémy
Molecules 2018, 23(1), 89; https://doi.org/10.3390/molecules23010089 - 02 Jan 2018
Cited by 24 | Viewed by 5564
Abstract
Glyconanoparticles essentially result from the (covalent or noncovalent) association of nanometer-scale objects with carbohydrates. Such glyconanoparticles can take many different forms and this mini review will focus only on soft materials (colloids, liposomes, gels etc.) with a special emphasis on glycolipid-derived nanomaterials and [...] Read more.
Glyconanoparticles essentially result from the (covalent or noncovalent) association of nanometer-scale objects with carbohydrates. Such glyconanoparticles can take many different forms and this mini review will focus only on soft materials (colloids, liposomes, gels etc.) with a special emphasis on glycolipid-derived nanomaterials and the chemistry involved for their synthesis. Also this contribution presents Low Molecular Weight Gels (LMWGs) stabilized by glycoconjugate amphiphiles. Such soft materials are likely to be of interest for different biomedical applications. Full article
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