Special Issue "Oligosaccharides and Glyco-Conjugates"
Deadline for manuscript submissions: closed (31 March 2014)
Carbohydrates occur naturally as oligo- and polysaccharides and are often coupled to peptides. proteins and lipids. In particular, oligosaccharides and glyco-conjugates have key roles in a broad range of biological processes. In many cases, changes in the sugar structures can affect the biological properties of the parent compounds. Furthermore, functional properties of drugs such as solubility, pharmacokinetics or pharmacodynamics can be enhanced by the incorporation of carbohydrate moieties into the molecules.
Methods for synthesizing these molecules have, therefore, acquired immense importance, because it is not easy to isolate sufficient amounts of acceptable pure product from natural sources.
On the other hand, the structure of therapeutic bio-products is critically important for their efficacy and safety, and the ability to characterize it at various levels (from sequence to conformation) is critical not only at the quality control stage, but also throughout the discovery and design stages because these structural information enable to optimize and enhance their therapeutic profile in a rational fashion.
Many analytical technologies have been deeply improved in the last years for determining the exact structure of complex oligosaccharides and glyco-conjugates For example Liquid Chromatography coupled to mass spectrometry (LC-MS) offers a variety of approaches to study structure and behaviour of complex protein drugs and has already become a default tool for characterizing the covalent structure, including sequence and post-translational modifications such as glycosylation which is the most common PTM in currently developed biopharmaceuticals.
Research papers dealing with the study and development of new compounds as well as new synthetic approaches, including new enzymatic or chemoenzymatic methods, new methods for analytical and biological characterization of oligosaccharides and glyco-conjugates, are welcomed for inclusion into this Special Issue of Molecules. Review articles, particularly those dealing with retrospective analyses of prior successes in the discovery and/or development of new drugs based on oligosaccharides and glyco-conjugates, are also welcomed for inclusion.
Prof. Dr. Marco Terreni
Dr. Caterina Temporini
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- structure characterization
- biological activity
- structure based drug design
- drug discovery and development