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Molecules
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Smart Polymer Hydrogels
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Smart Polymer Hydrogels

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 2160

Special Issue Editors

Prof. Dr. Afang Zhang

E-Mail Website
Guest Editor
International Joint Laboratory of Biomimetic and Smart Polymers, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
Interests: dendronized polymer; stimuli-responsive polymer; helical polymer; supramolecular chiral assembly; stimuli-responsive biomaterial
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Wen Li

E-Mail Website
Guest Editor
International Joint Laboratory of Biomimetic & Smart Polymers, Shanghai University, Shanghai, China
Interests: topological polymers; stimuli-responsive hydrogels; droplet-microfluidics for fabrication of microparticles

Special Issue Information

Dear Colleagues,

Macromolecular networks and gels, especially hydrogels, synthetic or natural, specially designed, hybrid or interpenetrating are intriguing materials which inspire researchers by their similarity to natural tissues, living matter which provides large scale of advanced functions of life. Nowadays, hydrogels are widely used in a variety of fields, the topic of crosslinked state of matter also attracts great attention of scientific community.

We therefore want to compose a special issue of the Molecules journal. This Special Issue will cover both fundamental and applied aspects, with special emphasis on hydrogels in biomedical applications, such as their responsivity, drug delivery, tissue engineering and their structure, other properties.

We hope that you will find this idea of a common project of putting together a special issue of Polymers interesting and we are looking forward to your contribution!

Prof. Dr. Afang Zhang
Prof. Dr. Wen Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hydrogels
  • Stimuli-Responsive Polymers
  • Drug Delivery
  • Tissue Engineering

Published Papers (1 paper)

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Research

10 pages, 2746 KiB  
Article
Smart Pellets for Controlled Delivery of 5-Fluorouracil
by Mohammad F. Bayan, Abdolelah Jaradat, Mohammad H. Alyami and Abdallah Y. Naser
Molecules 2023, 28(1), 306; https://doi.org/10.3390/molecules28010306 - 30 Dec 2022
Cited by 13 | Viewed by 1660
Abstract
This work aimed to develop a new one-pot and readily scaled-up formulation capable of retaining 5-fluorouracil and prolonging its release to obtain a site-specific medication delivery for the potential treatment of colorectal cancer. Six polymer-based formulations were successfully produced using a thermal bulk [...] Read more.
This work aimed to develop a new one-pot and readily scaled-up formulation capable of retaining 5-fluorouracil and prolonging its release to obtain a site-specific medication delivery for the potential treatment of colorectal cancer. Six polymer-based formulations were successfully produced using a thermal bulk polymerization method and loaded with 5-fluorouracil, which is a chemotherapeutic agent used in the treatment of colorectal carcinoma. The pellets produced were characterized by measuring the glass transition temperature, tensile strength, Young’s modulus, and tensile elongation at break. Studies on in vitro swelling and release were carried out in phosphate-buffered saline to evaluate the behaviour of the developed system. The Young’s modulus, glass transition temperature, and tensile strength all increased significantly as the crosslinker concentration increased, but the fracture strain value reduced significantly. The in vitro swelling profile of the produced formulations was significantly reduced by increasing crosslinking density. Less than 27% cumulative drug release was achieved for all formulations after 5 h of starting the release study. The highest cumulative drug release reached after 24 h was 69%. The developed drug delivery system demonstrated the ability to delay the release of 5-fluorouracil in upper gastrointestinal tract-mimicking conditions, while permitting its release in a controlled way afterward, which makes it promising for the potential delivery of 5-fluorouracil to the colon. Full article
(This article belongs to the Special Issue Smart Polymer Hydrogels)
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