Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 December 2019) | Viewed by 3659
Special Issue Editor
Interests: synthesis and biological studies on anti-inflammatory and antioxidant agents, on inhibitors of enzymes implicated in the inflammation and in the coagulation process in general; correlation of inflammation with cancer; neurodegeneration; antioxidant activity; theoretical and experimental calculation of physicochemical parameters implicated in biological response; use of computational chemistry in drug design as well as bioactive compounds of natural origin, e.g., essential oils
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nowadays, there is great interest in the use of pleiotropic/multifunctional/multitarget drugs for the treatment of complex diseases, in which more than one target is implicated. Multifactorial disorders like inflammation, cancer, and Alzheimer’s disease can be characterised as complex diseases. Inflammation is the natural response of the biological system to various stimuli. Excessive chronic inflammation is linked to reactive oxygen species and oxidative stress and leads to pathological disorders, such as atherosclerosis, rheumatoid arthritis, neurogenerative diseases and various types of cancer. Thus, molecules acting against several biological targets implicated in inflammation presenting anti-inflammatory and/or, antioxidant and/or anticoagulant activities will be useful.
Pyrrole is a privileged chemical scaffold correlated with interesting bioactivities. The pyrrole ring is an imperative structural framework found in a variety of biologically-active natural products and pharmaceutically-active molecules. The ability to form chelate complexes with metals explains the significance of pyrrole derivatives in biological systems. Pyrrolyl derivatives are referred to act as effective pleiotropic bioactive agents and for this reason there is great interest in these substances within medicinal chemistry.
Prof. Dr. Dimitra Hadjipavlou-Litina
Guest Editor
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Keywords
- pyrrole derivatives
- hybrids
- multifunctional/pleiotropic/multitarget agents
- synthesis
- quantitative structure/activity relationships QSAR
- modelling
- drug design
