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Nanomaterials
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Nanomaterials for Regenerative Medicine
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Nanomaterials for Regenerative Medicine

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 1851

Special Issue Editor

Dr. Hisao Haniu

E-Mail Website
Guest Editor
Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
Interests: bone regeneration; nerve regeneration; safety and toxicity assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Regenerative medicine offers tremendous potential in addressing the limitations of traditional treatments by promoting the regeneration and repair of damaged tissues and organs. Nanomaterials, with their unique properties and precise control over physical and chemical characteristics, have emerged as promising tools in this field. They enable the targeted delivery of therapeutic agents, enhance cellular interactions, and provide scaffolding support for tissue engineering.

This Special Issue seeks to showcase cutting-edge research, innovative approaches, and novel nanomaterial-based strategies that can revolutionize regenerative medicine. We welcome contributions from researchers, scientists, and experts from various disciplines, including materials science, bioengineering, nanotechnology, and biomedicine.

Potential topics of interest for submission include, but are not limited to, the following:

  • Design and synthesis of nanomaterials for regenerative medicine;
  • Characterization techniques and evaluation of nanomaterials for biomedical applications;
  • Nanomaterial-based drug delivery systems for regenerative therapies;
  • Nanomaterials for tissue engineering and organ regeneration;
  • Nanotechnology-enabled approaches for stem cell therapies;
  • Biofunctionalization of nanomaterials for enhanced biocompatibility and therapeutic efficacy;
  • Safety, toxicity, and regulatory aspects of nanomaterials in regenerative medicine.

We encourage authors to present original research, comprehensive reviews, or perspective articles that highlight the latest breakthroughs, challenges, and future directions in this exciting field.

Dr. Hisao Haniu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • therapeutic applications
  • targeted delivery
  • tissue engineering
  • biocompatibility
  • scaffolding
  • stem cell
  • organ regeneration
  • safety and toxicity assessment

Published Papers (2 papers)

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Research

24 pages, 3217 KiB  
Article
Apatite/Chitosan Composites Formed by Cold Sintering for Drug Delivery and Bone Tissue Engineering Applications
by Anna Galotta, Öznur Demir, Olivier Marsan, Vincenzo M. Sglavo, Dagnija Loca, Christèle Combes and Janis Locs
Nanomaterials 2024, 14(5), 441; https://doi.org/10.3390/nano14050441 - 28 Feb 2024
Viewed by 765
Abstract
In the biomedical field, nanocrystalline hydroxyapatite is still one of the most attractive candidates as a bone substitute material due to its analogies with native bone mineral features regarding chemical composition, bioactivity and osteoconductivity. Ion substitution and low crystallinity are also fundamental characteristics [...] Read more.
In the biomedical field, nanocrystalline hydroxyapatite is still one of the most attractive candidates as a bone substitute material due to its analogies with native bone mineral features regarding chemical composition, bioactivity and osteoconductivity. Ion substitution and low crystallinity are also fundamental characteristics of bone apatite, making it metastable, bioresorbable and reactive. In the present work, biomimetic apatite and apatite/chitosan composites were produced by dissolution–precipitation synthesis, using mussel shells as a calcium biogenic source. With an eye on possible bone reconstruction and drug delivery applications, apatite/chitosan composites were loaded with strontium ranelate, an antiosteoporotic drug. Due to the metastability and temperature sensitivity of the produced composites, sintering could be carried out by conventional methods, and therefore, cold sintering was selected for the densification of the materials. The composites were consolidated up to ~90% relative density by applying a uniaxial pressure up to 1.5 GPa at room temperature for 10 min. Both the synthesised powders and cold-sintered samples were characterised from a physical and chemical point of view to demonstrate the effective production of biomimetic apatite/chitosan composites from mussel shells and exclude possible structural changes after sintering. Preliminary in vitro tests were also performed, which revealed a sustained release of strontium ranelate for about 19 days and no cytotoxicity towards human osteoblastic-like cells (MG63) exposed up to 72 h to the drug-containing composite extract. Full article
(This article belongs to the Special Issue Nanomaterials for Regenerative Medicine)
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14 pages, 2983 KiB  
Article
Three-Dimensional Modeling with Osteoblast-like Cells under External Magnetic Field Conditions Using Magnetic Nano-Ferrite Particles for the Development of Cell-Derived Artificial Bone
by Chuang Ma, Makoto Izumiya, Hidehiko Nobuoka, Rintaro Ueno, Masaki Mimura, Katsuya Ueda, Haruka Ishida, Daihachiro Tomotsune, Kohei Johkura, Fengming Yue, Naoto Saito and Hisao Haniu
Nanomaterials 2024, 14(3), 251; https://doi.org/10.3390/nano14030251 - 23 Jan 2024
Viewed by 815
Abstract
The progress in artificial bone research is crucial for addressing fractures and bone defects in the aging population. However, challenges persist in terms of biocompatibility and structural complexity. Nanotechnology provides a promising avenue by which to overcome these challenges, with nano-ferrite particles (NFPs) [...] Read more.
The progress in artificial bone research is crucial for addressing fractures and bone defects in the aging population. However, challenges persist in terms of biocompatibility and structural complexity. Nanotechnology provides a promising avenue by which to overcome these challenges, with nano-ferrite particles (NFPs) exhibiting superparamagnetic properties. The ability to control cell positioning using a magnetic field opens up new possibilities for customizing artificial bones with specific shapes. This study explores the biological effects of NFPs on osteoblast-like cell lines (MC3T3-E1), including key analyses, such as cell viability, cellular uptake of NFPs, calcification processes, cell migration under external magnetic field conditions, and three-dimensional modeling. The results indicate that the impact of NFPs on cell proliferation is negligible. Fluorescence and transmission electron microscopy validated the cellular uptake of NFPs, demonstrating the potential for precise cell positioning through an external magnetic field. Under calcification-inducing conditions, the cells exhibited sustained calcification ability even in the presence of NFPs. The cell movement analysis observed the controlled movement of NFP-absorbing cells under an external magnetic field. Applying a magnetic field along the z-axis induced the three-dimensional shaping of cells incorporating NFPs, resulting in well-arranged z-axis directional patterns. In this study, NFPs demonstrated excellent biocompatibility and controllability under an external magnetic field, laying the foundation for innovative treatment strategies for customizing artificial bones. Full article
(This article belongs to the Special Issue Nanomaterials for Regenerative Medicine)
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