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Nanomaterials
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Carbon-Based Nanomaterials for Bone Regeneration
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Carbon-Based Nanomaterials for Bone Regeneration

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (16 March 2020) | Viewed by 17851

Special Issue Editor

Dr. Hisao Haniu

E-Mail Website
Guest Editor
Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
Interests: bone regeneration; nerve regeneration; safety and toxicity assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbon nanomaterials have attracted a great deal of attention in the biological and medical science fields because of their unique physical and biological properties. Carbon nanomaterials possess high biocompatibility with bone tissue, and possible roles in bone regeneration have already been identified. Moreover, many composite materials developed using carbon nanomaterials are being tested as scaffolds and fillers for bone tissue regeneration. Since bony nonunion and large skeletal defects created by tumors, trauma, and congenital malformations are sometimes impossible to repair, clinicians are in need of innovative technologies for bone regeneration.
This Special Issue invites all manuscripts involving the direct effects of carbon nanomaterials and their composites in bone tissue and cells in vivo and in vitro, the availability of such materials for scafolding and filler material, and novel suggestions on their clinical implementation. Safety evaluations of the practical application of carbon nanomaterials are also welcome in this issue.

Prof. Hisao Haniu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon nanomaterials
  • bone regeneration
  • composite materials
  • scaffold
  • filler
  • safety evaluation

Published Papers (3 papers)

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Review

15 pages, 2650 KiB  
Review
Applications of Carbon Nanotubes in Bone Regenerative Medicine
by Manabu Tanaka, Kaoru Aoki, Hisao Haniu, Takayuki Kamanaka, Takashi Takizawa, Atsushi Sobajima, Kazushige Yoshida, Masanori Okamoto, Hiroyuki Kato and Naoto Saito
Nanomaterials 2020, 10(4), 659; https://doi.org/10.3390/nano10040659 - 2 Apr 2020
Cited by 21 | Viewed by 3763
Abstract
Scaffolds are essential for bone regeneration due to their ability to maintain a sustained release of growth factors and to provide a place where cells that form new bone can enter and proliferate. In recent years, scaffolds made of various materials have been [...] Read more.
Scaffolds are essential for bone regeneration due to their ability to maintain a sustained release of growth factors and to provide a place where cells that form new bone can enter and proliferate. In recent years, scaffolds made of various materials have been developed and evaluated. Functionally effective scaffolds require excellent cell affinity, chemical properties, mechanical properties, and safety. Carbon nanotubes (CNTs) are fibrous nanoparticles with a nano-size diameter and have excellent strength and chemical stability. In the industrial field, they are used as fillers to improve the performance of materials. Because of their excellent physicochemical properties, CNTs are studied for their promising clinical applications as biomaterials. In this review article, we focused on the results of our research on CNT scaffolds for bone regeneration, introduced the promising properties of scaffolds for bone regeneration, and described the potential of CNT scaffolds. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Bone Regeneration)
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14 pages, 1753 KiB  
Review
The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration
by Kaoru Aoki, Hisao Haniu, Yoong Ahm Kim and Naoto Saito
Nanomaterials 2020, 10(3), 562; https://doi.org/10.3390/nano10030562 - 20 Mar 2020
Cited by 27 | Viewed by 3495
Abstract
There has been an increasing amount of research on regenerative medicine for the treatment of bone defects. Scaffolds are needed for the formation of new bone, and various scaffolding materials have been evaluated for bone regeneration. Materials with pores that allow cells to [...] Read more.
There has been an increasing amount of research on regenerative medicine for the treatment of bone defects. Scaffolds are needed for the formation of new bone, and various scaffolding materials have been evaluated for bone regeneration. Materials with pores that allow cells to differentiate into osteocytes are preferred in scaffolds for bone regeneration, and porous materials and fibers are well suited for this application. Electrospinning is an effective method for producing a nanosized fiber by applying a high voltage to the needle tip containing a polymer solution. The use of electrospun nanofibers is being studied in the medical field, and its use as a scaffold for bone regeneration therapy has become a topic of growing interest. In this review, we will introduce the potential use of electrospun nanofiber as a scaffold for bone regenerative medicine with a focus on carbon nanofibers produced by the electrospinning method. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Bone Regeneration)
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39 pages, 7054 KiB  
Review
Applications of Carbon Nanotubes in Bone Tissue Regeneration and Engineering: Superiority, Concerns, Current Advancements, and Prospects
by Baoqing Pei, Wei Wang, Nicholas Dunne and Xiaoming Li
Nanomaterials 2019, 9(10), 1501; https://doi.org/10.3390/nano9101501 - 22 Oct 2019
Cited by 117 | Viewed by 10020
Abstract
With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure [...] Read more.
With advances in bone tissue regeneration and engineering technology, various biomaterials as artificial bone substitutes have been widely developed and innovated for the treatment of bone defects or diseases. However, there are no available natural and synthetic biomaterials replicating the natural bone structure and properties under physiological conditions. The characteristic properties of carbon nanotubes (CNTs) make them an ideal candidate for developing innovative biomimetic materials in the bone biomedical field. Indeed, CNT-based materials and their composites possess the promising potential to revolutionize the design and integration of bone scaffolds or implants, as well as drug therapeutic systems. This review summarizes the unique physicochemical and biomedical properties of CNTs as structural biomaterials and reinforcing agents for bone repair as well as provides coverage of recent concerns and advancements in CNT-based materials and composites for bone tissue regeneration and engineering. Moreover, this review discusses the research progress in the design and development of novel CNT-based delivery systems in the field of bone tissue engineering. Full article
(This article belongs to the Special Issue Carbon-Based Nanomaterials for Bone Regeneration)
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