The Impact of Nutrition on Brain Metabolism and Disease (2nd Edition)

Dear Colleagues,

In recent decades, the link between nutrition, brain health, and risk of central nervous system pathologies has been highlighted. Brain status strongly depends on energy availability, and diet can deeply impact brain functions including synaptic plasticity, cognitive processes, and neuroendocrine functions and behavior, thus affecting health.

Diet manipulation, i.e., both dietary supplement (such as sugars, fatty acids, plant extracts, vitamins, amino acids, fibers) and dietary restriction (in particular dietary patterns, amino acid restriction and fasting), has considerable effects on brain physiology and could be of particular importance in the context of global human aging, which is associated with the increase of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, etc. How different diets/nutritional strategies (from single micro/macronutrients, to complex foods that differ in energy density and natural compounds, and/or functional food including prebiotics, probiotics, and postbiotics) modulate brain function and homeostasis, with special regard to metabolism, mitochondrial function, redox homeostasis, insulin signaling, neuroinflammation, gut/brain axis, synaptic function, and plasticity, is the focus of this Special Issue. Studies that further unravel mechanistic links between diet composition and nutritional status and the onset or prevention of neurodevelopmental or neurodegenerative diseases are welcomed, in order to provide new insights into physiopathological aspects underlying brain development, function, and aging.

Original research reports and review articles from experts in the field will provide an interdisciplinary approach to highlight the beneficial or deleterious impact of different nutritional plans and could represent milestones for designing novel therapeutic targets to counteract several brain diseases linked with malnutrition.

Dr. Luisa Cigliano
Dr. Maria Stefania Spagnuolo
Dr. Arianna Mazzoli
Guest Editors

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• brain mitochondria
• brain oxidative stress
• neuroinflammation
• brain insulin signaling
• brain lipid metabolism
• brain aging
• neurodegenerative diseases
• neurodevelopmental disorders
• microbiome and brain
• mood disorder and nutrition