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Nutrients
Special Issues
Diet and Nutrition Approaches in Obesity Treatment
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Diet and Nutrition Approaches in Obesity Treatment

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 5 October 2024 | Viewed by 6552

Special Issue Editors

Prof. Dr. Kuo-Chin Huang

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Guest Editor
Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan
Interests: obesity; management of obesity; obesity-related biomarkers
Special Issues, Collections and Topics in MDPI journals
Dr. Wen-Harn Pan

E-Mail Website
Guest Editor
Institute of Biomedical Sciences, Academia Sinica, 128 Sec. 2, Academia Rd. Nankang, Taipei 115, Taiwan
Interests: nutrition epidemiology; nutrition survey; cardiovascular epidemiology; geriatric syndrome; dietary intervention; community-based intervention; genomics; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obesity is a global health challenge that affects millions of people and raises the risk of developing various chronic diseases. It stems from the obesogenic environment of modern society, which fosters a sedentary lifestyle and the consumption of high-energy-dense foods. However, obesity management is not only about reducing food intake and increasing physical activity, it also requires novel foods and measures to sustain behavioral changes and resistance to the obesogenic environment. This Special Issue seeks to explore innovative and effective strategies to help people overcome the obesogenic environment and adopt a healthy lifestyle in the long term. We welcome creative qualitative or quantitative research that examines the potential measures that influence people’s weight. We invite scholars from diverse disciplines and backgrounds to share their ideas and findings on this crucial topic. We hope that this Special Issue will offer new insights and solutions for obesity prevention and management in the modern world.

Prof. Dr. Kuo-Chin Huang
Dr. Wen-Harn Pan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet and nutrition
  • food
  • feeding behavior
  • obesity
  • weight loss and maintenance

Published Papers (5 papers)

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Research

22 pages, 1174 KiB  
Article
Healthcare Service Providers’ Perspectives on Sociocultural Aspects Affecting Weight Management Activities Amongst People with Obesity in Taiwan—A Qualitative Study
by Jodie Leu, Kuo-Chin Huang, Pey-Rong Chen and Wen-Harn Pan
Nutrients 2024, 16(10), 1540; https://doi.org/10.3390/nu16101540 - 20 May 2024
Viewed by 178
Abstract
The prevalence of obesity and morbid obesity in Taiwan has risen sharply in recent decades, as in other parts of the world, necessitating urgent action to prevent and curb its detrimental effects. Asian populations are susceptible to the repercussions of obesity at a [...] Read more.
The prevalence of obesity and morbid obesity in Taiwan has risen sharply in recent decades, as in other parts of the world, necessitating urgent action to prevent and curb its detrimental effects. Asian populations are susceptible to the repercussions of obesity at a lower body weight. A higher BMI is associated with more frequent outpatient visits, in-hospital admissions, higher medical costs, and a lower quality of life. However, effective weight management approaches are unlikely to be maintained in the long term without assimilation into daily lifestyle practices. This qualitative study, based on semi-structured interviews with 14 doctors, dieticians, and nurses who work to control the weight of people with obesity, explored and identified multilevel barriers in the context of daily life to improve the efficacy and execution of weight management strategies. They considered diets, physical activity, and sleep as key weight management activities. The cultural and psychosocial aspects of daily life were observed to have an impact upon weight management, particularly family conflicts due to cultural dynamics and socially and culturally reinforced food practices. To improve population weight, less-recognised aspects need to be addressed alongside the inclusion of mental health specialists in weight management protocols and policy interventions to minimise obesogenic practices and create environments conducive to weight management. Full article
(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)
17 pages, 772 KiB  
Article
Metabolomic Profiling of Obese Patients with Altered Intestinal Permeability Undergoing a Very Low-Calorie Ketogenic Diet
by Francesco Maria Calabrese, Giuseppe Celano, Giuseppe Riezzo, Benedetta D’Attoma, Antonia Ignazzi, Martina Di Chito, Annamaria Sila, Sara De Nucci, Roberta Rinaldi, Michele Linsalata, Mirco Vacca, Carmen Aurora Apa, Maria De Angelis, Gianluigi Giannelli, Giovanni De Pergola and Francesco Russo
Nutrients 2023, 15(24), 5026; https://doi.org/10.3390/nu15245026 - 7 Dec 2023
Cited by 1 | Viewed by 1397
Abstract
A healthy intestinal permeability facilitates the selective transport of nutrients, metabolites, water, and bacterial products, involving cellular, neural, hormonal, and immune factors. An altered intestinal permeability indicates pathologic phenotypes and is associated with the exacerbation of obesity and related comorbidities. To investigate the [...] Read more.
A healthy intestinal permeability facilitates the selective transport of nutrients, metabolites, water, and bacterial products, involving cellular, neural, hormonal, and immune factors. An altered intestinal permeability indicates pathologic phenotypes and is associated with the exacerbation of obesity and related comorbidities. To investigate the impact of altered permeability in obese patients undergoing a calorie-restrictive dietary regimen (VLCKD), we collected urinary and fecal samples from obese patients with both normal and altered permeability (determined based on the lactulose/mannitol ratio) before and after treatment. The analysis of volatile organic compounds (VOCs) aids in understanding the metabolites produced by the intestinal microbiota in this unique ecological niche. Furthermore, we examined clinical and anthropometric variables from the cohort and compared them to significant VOC panels. Consequently, we identified specific markers in the metabolomics data that differentiated between normal and altered profiles before and after the diet. These markers indicated how the variable contribution specifically accounted for interleukins and lipopolysaccharides (LPS). The targeted metabolomics experiment detected no differences in measured short-chain fatty acids (SCFA). In summary, our study evaluated metabolomic markers capable of distinguishing low-grade inflammation conditions, exacerbated in more advanced stages of obesity with altered intestinal permeability. Full article
(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)
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17 pages, 8569 KiB  
Article
Theabrownin from Wuniuzao Dark Tea Regulates Hepatic Lipid Metabolism and Gut Microbiota in Mice Fed High-Fat Diet
by Qianqian Xu, Jiangcheng Ye, Mingxiu Gong, Yifan Zhang, Yiwei Yuan and Jin Zhao
Nutrients 2023, 15(23), 4912; https://doi.org/10.3390/nu15234912 - 24 Nov 2023
Cited by 2 | Viewed by 1181
Abstract
The search for functional foods with no side effects that can alleviate obesity has been a common trend. Wuniuzao dark tea could be a safe choice. This study aimed to explore whether theabrownin from Wuniuzao dark tea could regulate hepatic lipid metabolism and [...] Read more.
The search for functional foods with no side effects that can alleviate obesity has been a common trend. Wuniuzao dark tea could be a safe choice. This study aimed to explore whether theabrownin from Wuniuzao dark tea could regulate hepatic lipid metabolism and gut microbiota in mice fed a high-fat diet. In total, fifty 8-week-old male C57BL/6 mice were randomly divided into five treatment groups, including a normal control group, high-fat diet group, positive control group, low-dose theabrownin group, and high-dose theabrownin group. After a 9-week intervention, these mice were selected from each treatment group for sampling. The results showed that the body weight and epididymis fat weight of obese mice fed with theabrownin were decreased. Serum total triglycerides, total cholesterol, and low-density lipoprotein cholesterol, and activities of aspartate aminotransferase and alanine aminotransferase were also decreased. Protein and mRNA expression of fatty acid synthesis and lipid production-related genes of mice fed with theabrownin were downregulated. The gut microbiota composition in the theabrownin group was improved. The study indicated that theabrownin from Wuniuzao dark tea could achieve the liver protection and anti-obesity effects by regulating the Srebp lipid metabolism pathway and bile acid metabolism process, and improving the gut microbiota composition of mice. Full article
(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)
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16 pages, 531 KiB  
Article
Impact of a Food Rebalancing Program Associated with Plant-Derived Food Supplements on the Biometric, Behavioral, and Biological Parameters of Obese Subjects
by Jean-Jacques Houben, Yvon Carpentier, Genevieve Paulissen, Georges Van Snick and Antoine Soetewey
Nutrients 2023, 15(22), 4780; https://doi.org/10.3390/nu15224780 - 14 Nov 2023
Viewed by 2054
Abstract
Between 2021 and 2023, the Scientific Council of Dietplus®, a group specialized in overweight and obesity management, conducted a clinical study on 170 volunteer subjects with a BMI > 29 Kg/m2 consecutively recruited. The Dietplus® program comprises nutritional education, [...] Read more.
Between 2021 and 2023, the Scientific Council of Dietplus®, a group specialized in overweight and obesity management, conducted a clinical study on 170 volunteer subjects with a BMI > 29 Kg/m2 consecutively recruited. The Dietplus® program comprises nutritional education, intensive, personalized coaching, and consuming food supplements rich in plant derivatives. The aim of this study was to assess the effect of the Dietplus® program on biometric, behavioral, and biological parameters. A control group of 30 obese patients was followed for a similar 12-week period. Mean weight loss reached 9 ± 2.1 kg in the Dietplus® test group versus a 1 ± 0.1 kg weight gain in the control group. Excess weight loss reached 33 ± 13%, and fat mass loss was 7.6% (p < 0.001); waist circumference was reduced by 30%. Quality of Life, Nutriscore, and Prochaska di Clemente scale significantly improved (p < 0.001). Biological parameters showed substantial improvements in the carbohydrate profile and insulin resistance (HOMA index) and in the lipid profile with lower plasma triglyceride (p < 0.01) and VLDL (p < 0.01) concentrations. Inflammatory parameters (orosomucoid, ultrasensitive C-reactive protein, and PINI indices) were also substantially reduced. These results indicate a substantial benefit in subjects who followed the Dietplus® program. (Dietplus® 116 Rue Robert Bunsen, 57460 Behren-lès-Forbach, France is active in France Belgium and Spain. Plant Derived Food Supplements are produced in France). Indeed, improvements were observed in all biometric, behavioral, and metabolic parameters. Full article
(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)
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20 pages, 4445 KiB  
Article
Short-Term Effects of Weight-Loss Meal Replacement Programs with Various Macronutrient Distributions on Gut Microbiome and Metabolic Parameters: A Pilot Study
by Seungmin Song, Jinyoung Shon, Woo-ri Yang, Han-Bit Kang, Keun-Ha Kim, Ju-Yeon Park, Sanghoo Lee, Sae Yun Baik, Kyoung-Ryul Lee and Yoon Jung Park
Nutrients 2023, 15(22), 4744; https://doi.org/10.3390/nu15224744 - 10 Nov 2023
Cited by 1 | Viewed by 1277
Abstract
It has emerged the gut microbiome is crucially linked to metabolic health and obesity. Macronutrient distribution has been discussed as a key parameter in weight-loss programs, but little is known about its impact on the gut microbiome. We investigated the effects of weight-loss [...] Read more.
It has emerged the gut microbiome is crucially linked to metabolic health and obesity. Macronutrient distribution has been discussed as a key parameter in weight-loss programs, but little is known about its impact on the gut microbiome. We investigated the effects of weight-loss meal replacement programs with different macronutrient ratios on the gut microbiota and metabolic parameters in subjects with overweight and obesity. Three low-calorie meal replacement programs with different ratios of carbohydrates, proteins, and lipids were designed: a balanced diet (Group B, 60:15:30), a high-lipid−low-carbohydrate diet (Group F, 35:20:55), and a protein-enriched diet (Group P, 40:25:35). Sixty overweight or obese participants were provided with the meals twice daily for 3 weeks. In all groups, diet intervention resulted in reduced body weight and BMI. The relative abundance of Bacteroidetes and Firmicutes phyla decreased and increased, respectively, which increased the Firmicutes/Bacteroidetes (F/B) ratio in all subjects, particularly in Groups B and P. Alpha- and beta-diversity were augmented at the phylum level in Group P. In conclusion, short-term interventions with weight-loss meal replacement programs increased butyrate-producing bacteria and the F/B ratio. Moreover, the protein-enriched diet significantly increased alpha- and beta-diversity compared to the balanced diet and the high-lipid−low-carbohydrate diet. Full article
(This article belongs to the Special Issue Diet and Nutrition Approaches in Obesity Treatment)
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