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The Connection between Diet and the Presence of Obesity and Kidney Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 1334

Special Issue Editor


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Guest Editor
Obesity, Diabetes and Metabolism (ODIM) Research Group, Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, IRBLleida, University of Lleida, 25198 Lleida, Spain
Interests: nutrition; obesity; metabolism; kidney disease; diagonose

Special Issue Information

Dear Colleagues,

The ability of a kidney to efficiently work is altered in obesity. Diabetic nephropathy is a common complication of diabetes. However, this risk extends to those who are free from diabetes, demonstrating that obesity per se contributes to chronic kidney disease (CKD). Several studies have established that obesity is linked with increased risk of developing CKD.

Some pathophysiology mechanisms that may contribute to kidney dysfunction have been described, such as inflammation and abnormal lipid metabolism. Dietary composition may have an influence in this problem, improving biomarkers like inflammation, lipid profile, arterial hypertension, etc. In addition, a healthy lifestyle has been associated with lower BMI values, and consequently, lower risk of obesity. Medical treatments for obesity and CKD are available in 2023.

In this Special Issue, we invite research papers focusing on the dietary approaches, food composition, and/or patterns of food intake that influence kidney function. Articles that shed light on how these factors can modulate obesity-linked CKD and their associated pathologies are welcome

Dr. Enric Sánchez
Guest Editor

Manuscript Submission Information

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Keywords

  • diabetes
  • body mass index
  • obesity
  • potassium
  • chronic kidney disease
  • dietary patterns
  • Mediterranean diet
  • hypoprotein diet
  • arterial hypertension
  • complications
  • adipose tissue
  • sodium

Published Papers (1 paper)

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Research

20 pages, 4052 KiB  
Article
microRNA Expression Profile in Obesity-Induced Kidney Disease Driven by High-Fat Diet in Mice
by Àuria Eritja, Maite Caus, Thalia Belmonte, David de Gonzalo-Calvo, Alicia García-Carrasco, Ana Martinez, Montserrat Martínez and Milica Bozic
Nutrients 2024, 16(5), 691; https://doi.org/10.3390/nu16050691 - 28 Feb 2024
Viewed by 819
Abstract
Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney microRNA (miRNA) expression profile in [...] Read more.
Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney microRNA (miRNA) expression profile in a model of obesity-induced kidney disease in C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led to notable structural alterations in tubular and glomerular regions of the kidney, increased renal expression of proinflammatory and profibrotic genes, as well as an elevated renal expression of genes involved in cellular lipid metabolism. The miRNA sequencing analysis identified a set of nine miRNAs differentially expressed in the kidney upon HFD feeding, with miR-5099, miR-551b-3p, miR-223-3p, miR-146a-3p and miR-21a-3p showing the most significant differential expression between standard diet (STD) and HFD mice. A validation analysis showed that the expression levels of miR-5099, miR-551b-3p and miR-146a-3p were consistent with NGS results, while Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses revealed that these three validated miRNAs modulated target genes involved in metabolic and adipocytokine pathways, fatty acid and lipid metabolism, and inflammatory, senescence and profibrotic pathways. Our results suggest that differentially expressed miRNAs play pivotal roles in the intricate pathophysiology of obesity-associated kidney disease and could potentially create novel treatment strategies to counteract the deleterious effects of obesity on kidney function. Full article
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