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Journals
Nutrients
Special Issues
Dietary Strategies in Metabolic Disorders
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Dietary Strategies in Metabolic Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 August 2024 | Viewed by 412

Special Issue Editors

Dr. Olga Pivovarova-Ramich

E-Mail Website
Guest Editor
Molecular Nutritional Medicine Research Group, German Institute of Human Nutrition, Potsdam-Rehbrücke, 14558 Nuthetal, Germany
Interests: diabetes; obesity; nutrition; metabolism; chronobiology
Special Issues, Collections and Topics in MDPI journals
Dr. Stefan Kabisch

E-Mail Website
Guest Editor
Department of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12203 Berlin, Germany
Interests: secretin; type 2 diabetes; NAFLD; nutrigenetics; intervention studies; dietary fiber; sweeteners and sugars; low-carb; dietary intervention; RCTs

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Dietary Strategies in Metabolic Disorders”, will explore the impact of the different types of nutritional intervention on metabolic diseases with an increasing prevalence worldwide, including type 2 diabetes and its complications, obesity, dyslipidemia, metabolic syndrome, atherosclerosis and metabolic liver disease. We aim to elucidate the role of the nutrient composition, calorie intake and eating timing in different aspects of the prevention and management of these metabolic disorders. We also welcome studies on novel molecular targets and the genetic background that regulates the metabolic response to nutrition. This content may be useful for medical doctors, practicing dieticians and nutritional researchers.

We look forward to the submission of interesting and attractive manuscripts, including original articles and review articles, to this Special Issue. 

Dr. Olga Pivovarova-Ramich
Dr. Stefan Kabisch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrient composition
  • calorie intake
  • eating timing
  • intermittent fasting
  • formula diet
  • diabetes mellitus
  • insulin resistance pre-diabetes
  • metabolic liver diseases
  • cardiovascular diseases
  • metabolic syndrome
  • dyslipidemia
  • obesity

Published Papers (1 paper)

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Research

17 pages, 2767 KiB  
Article
Hepatic-Metabolic Activity of α-Lipoic Acid—Its Influence on Sphingolipid Metabolism and PI3K/Akt/mTOR Pathway in a Rat Model of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Klaudia Sztolsztener and Adrian Chabowski
Nutrients 2024, 16(10), 1501; https://doi.org/10.3390/nu16101501 - 16 May 2024
Viewed by 289
Abstract
Excessive lipid deposition affects hepatic homeostasis and contributes to the development of insulin resistance as a crucial factor for the deterioration of simple steatosis to steatohepatitis. So, it is essential to search for an effective agent for a new therapy for hepatic steatosis [...] Read more.
Excessive lipid deposition affects hepatic homeostasis and contributes to the development of insulin resistance as a crucial factor for the deterioration of simple steatosis to steatohepatitis. So, it is essential to search for an effective agent for a new therapy for hepatic steatosis development before it progresses to the more advanced stages. Our study aimed to evaluate the potential protective effect of α-lipoic acid (α-LA) administration on the intrahepatic metabolism of sphingolipid and insulin signaling transduction in rats with metabolic dysfunction-associated steatotic liver disease (MASLD). The experiment was conducted on male Wistar rats subjected to a standard diet or a high-fat diet (HFD) and an intragastrically α-LA administration for eight weeks. High-performance liquid chromatography (HPLC) was used to determine sphingolipid content. Immunoblotting was used to measure the expression of selected proteins from sphingolipid and insulin signaling pathways. Multiplex assay kit was used to assess the level of the phosphorylated form of proteins from PI3K/Akt/mTOR transduction. The results revealed that α-LA decreased sphinganine, dihydroceramide, and sphingosine levels and increased ceramide level. We also observed an increased the concentration of phosphorylated forms of sphingosine and sphinganine. Changes in the expression of proteins from sphingolipid metabolism were consistent with changes in sphingolipid pools. Treatment with α-LA activated the PI3K/Akt/mTOR pathway, which enhanced the hepatic phosphorylation of Akt and mTOR. Based on these data, we concluded that α-lipoic acid may alleviate glucose intolerance and may have a protective influence on the sphingolipid metabolism under HFD; thus, this antioxidant appears to protect from MASLD development and steatosis deterioration. Full article
(This article belongs to the Special Issue Dietary Strategies in Metabolic Disorders)
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