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Nutrients
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Selenium-Rich Products: Their Development and Regulation of Human Health
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Selenium-Rich Products: Their Development and Regulation of Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 5 April 2025 | Viewed by 3067

Special Issue Editor

Dr. Jiaqiang Huang

E-Mail Website
Guest Editor
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
Interests: selenium; selenoprotein; health; Se-rich products; antioxidant

Special Issue Information

Dear Colleagues,

We are excited to announce a Special Issue of Nutrients on “Selenium-rich Products and Health”. Selenium (Se) is an essential trace element for both human health and animal nutrition. However, Se deficiency remains a nutritional challenge in some areas of the world and can cause serious health problems, including cardiovascular disease, Keshan disease, and cognitive decline. People acquire almost all of their Se intake through food, where, after its uptake, it performs various physiological functions in the body in the form of selenoproteins, which are well known for their redox activity and anti-inflammatory properties. Notably, Se’s assimilation efficiency from the diet depends on its form. Consequently, how to supplement Se more efficiently through the diet remains a critical subject to explore. Se can also promote wound healing in vitro (although not in vivo), which benefits from its anti-inflammatory, antibacterial, and angiogenic functional activities. Thus, more and more Se-rich products ought to be explored and innovated, alongside both their assimilation efficiency and health benefits.

This Special Issue of Nutrients will contain animal and human research on the production of several innovative Se-rich products, as well as their significance in health and illness, alongside considerations or discussions of genetic and metabolic aspects. We aim to provide new insights into the role of Se in maintaining and promoting health. We also encourage studies investigating Se as an intervention to improve health and the role of novel selenoproteins in health.

Dr. Jiaqiang Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • selenium
  • selenium-rich products
  • selenoproteins
  • health
  • disease

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Published Papers (3 papers)

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Research

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12 pages, 2693 KiB  
Article
Erythrocyte Selenium as a Potential Key Indicator for Selenium Supplementation in Low-Selenium Populations: A Selenium Supplementation Study Based on Wistar Rats
by Cunqi Lv, Ruixiang Wang, Qingyu Zeng, Chen Feng, Guijin Li, Shuxiu Hao, Jiacheng Li, Cheng Wang, Huixin Sun, Linlin Du, Yu Zhang, Xinshu Wang, Tong Wang and Qi Li
Nutrients 2024, 16(22), 3797; https://doi.org/10.3390/nu16223797 - 5 Nov 2024
Viewed by 349
Abstract
Background: Selenium (Se) is an essential trace element for maintaining human health, with significant antioxidant and immunoregulatory functions. Inadequate Se intake may be associated with Keshan disease, Kashin–Beck disease, and hypothyroidism. However, effective indicators for scientifically guiding Se supplementation in Se-deficient populations are [...] Read more.
Background: Selenium (Se) is an essential trace element for maintaining human health, with significant antioxidant and immunoregulatory functions. Inadequate Se intake may be associated with Keshan disease, Kashin–Beck disease, and hypothyroidism. However, effective indicators for scientifically guiding Se supplementation in Se-deficient populations are still lacking. Objectives: This study aims to explore the dynamic distribution of Se across various nutritional biomarkers and major organs in rats through a Se supplementation experiment, as well as the pairwise correlations between them, in order to identify reliable nutritional indicators for evaluating Se levels in the body. Methods: Se levels in hair, blood, and major tissues and organs were determined by atomic fluorescence spectrometry, and glutathione peroxidase (GSH-Px) levels were measured using an ELISA. Results: Se supplementation significantly increased Se levels in rat blood, hair, and major organs, as well as GSH-Px levels in blood. Se primarily accumulated in the liver and kidneys, followed by myocardium, spleen, and muscles. Serum and plasma Se were found to be the best indicators of short-term Se intake, while erythrocyte Se levels showed a stronger correlation with Se levels in tissues and organs, making it a better marker for assessing long-term Se nutritional status compared to hair Se. Conclusions: This study demonstrates the potential of erythrocyte Se levels as an indicator for evaluating long-term Se nutritional status, providing scientific evidence for Se nutritional assessments. Full article
(This article belongs to the Special Issue Selenium-Rich Products: Their Development and Regulation of Human Health)
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15 pages, 3338 KiB  
Article
Alleviation of Lipid Disorder and Liver Damage in High-Fat Diet-Induced Obese Mice by Selenium-Enriched Cardamine violifolia with Cadmium Accumulation
by Junying Zhu, Qingqing Lv, Fengna Li, Ping Xu, Ziyu Han, Aolin Yang, Zhan Shi, Chao Wang, Jie Jiang, Yunfen Zhu, Xiaofei Chen, Lvhui Sun, Xin Gen Lei and Ji-Chang Zhou
Nutrients 2024, 16(18), 3208; https://doi.org/10.3390/nu16183208 - 22 Sep 2024
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Abstract
Background/Objectives: As a hyperaccumulator of selenium (Se), Cardamine violifolia (Cv) and its peptide extract could ameliorate the negative effects of a high-fat diet (HFD). However, the effects of the coaccumulation of cadmium (Cd) in Se-enriched Cv (Cv2) and the [...] Read more.
Background/Objectives: As a hyperaccumulator of selenium (Se), Cardamine violifolia (Cv) and its peptide extract could ameliorate the negative effects of a high-fat diet (HFD). However, the effects of the coaccumulation of cadmium (Cd) in Se-enriched Cv (Cv2) and the potential confounding effect on the roles of enriched Se remain unknown. We aimed to investigate whether Cv2 could alleviate HFD-induced lipid disorder and liver damage. Methods: Three groups of 31-week-old female mice were fed for 41 weeks (n = 10–12) with a control Cv-supplemented diet (Cv1D, 0.15 mg Se/kg, 30 µg Cd/kg, and 10% fat calories), a control Cv-supplemented HFD (Cv1HFD, 45% fat calories), and a Cv2-supplemented HFD (Cv2HFD, 1.5 mg Se/kg, 0.29 mg Cd/kg, and 45% fat calories). Liver and serum were collected to determine the element concentrations, markers of liver injury and lipid disorder, and mRNA and/or protein expression of lipid metabolism factors, heavy metal detoxification factors, and selenoproteins. Results: Both Cv1HFD and Cv2HFD induced obesity, and Cv2HFD downregulated Selenoi and upregulated Dio3 compared with Cv1D. When comparing Cv2HFD against Cv1HFD, Cv2 increased the liver Se and Cd, the protein abundance of Selenoh, and the mRNA abundance of 10 selenoproteins; reduced the serum TG, TC, and AST; reduced the liver TG, lipid droplets, malondialdehyde, and mRNA abundance of Mtf1 and Mt2; and differentially regulated the mRNA levels of lipid metabolism factors. Conclusions: Cv2 alleviated HFD-induced lipid dysregulation and liver damage, which was probably associated with its unique Se speciation. However, further research is needed to explore the interaction of plant-coenriched Se and Cd and its effects on health. Full article
(This article belongs to the Special Issue Selenium-Rich Products: Their Development and Regulation of Human Health)
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Review

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14 pages, 915 KiB  
Review
Effect of Selenium and Selenoproteins on Radiation Resistance
by Shidi Zhang, Guowei Zhang, Pengjie Wang, Lianshun Wang, Bing Fang and Jiaqiang Huang
Nutrients 2024, 16(17), 2902; https://doi.org/10.3390/nu16172902 - 30 Aug 2024
Viewed by 899
Abstract
With the advancement of radiological medicine and nuclear industry technology, radiation is increasingly used to diagnose human health disorders. However, large-scale nuclear leakage has heightened concerns about the impact on human organs and tissues. Selenium is an essential trace element that functions in [...] Read more.
With the advancement of radiological medicine and nuclear industry technology, radiation is increasingly used to diagnose human health disorders. However, large-scale nuclear leakage has heightened concerns about the impact on human organs and tissues. Selenium is an essential trace element that functions in the body mainly in the form of selenoproteins. Selenium and selenoproteins can protect against radiation by stimulating antioxidant actions, DNA repair functions, and immune enhancement. While studies on reducing radiation through antioxidants have been conducted for many years, the underlying mechanisms of selenium and selenoproteins as significant antioxidants in radiation damage mitigation remain incompletely understood. Therefore, this paper aims to provide new insights into developing safe and effective radiation protection agents by summarizing the anti-radiation mechanism of selenium and selenoproteins. Full article
(This article belongs to the Special Issue Selenium-Rich Products: Their Development and Regulation of Human Health)
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