Nutrients

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Special Issue Information

Dear Colleagues,

Nutrition exerts a profound influence on not just the etiology but also the pathogenesis of liver disease. Historically, it has been recognized that chronic illnesses can precipitate malnutrition, particularly cirrhosis. Conversely, malnutrition has been identified as a contributing factor to the progression of these hepatic conditions.

Recently, the prevalence of steatotic liver disease, commonly known as fatty liver, has risen steeply in parallel with the global surge in obesity rates. This has led to an expanded conceptualization of malnutrition to encompass over-nutrition, alongside the conventional issue of under-nutrition.

Both states of malnutrition, whether characterized by deficits or excesses in nutritional intake, exert multifaceted influences on the development and trajectory of chronic liver diseases. Our overarching goal is to provide an extensive forum for the dissemination of diverse viewpoints, empirical research findings, and international guidelines pertinent to the intricate interplay between nutrition and chronic liver diseases. This includes elucidating diagnostic and therapeutic methodologies.

We cordially invite scholarly contributions that adopt a holistic perspective, encompassing broader aspects such as overall health, physical activity, and lifestyle interventions. These contributions may offer insights into diagnostic and therapeutic modalities tailored to individuals afflicted by chronic liver diseases. Additionally, we welcome submissions that delve into optimal nutritional interventions and articles with a focal point on chronic liver disease.

Furthermore, we encourage submissions elucidating the interface between nutrition and sarcopenia, a recognized significant mediator in the realm of chronic liver diseases. Of particular interest are the latest research findings concerning the intricate interrelationships between genetic factors and nutrition, as well as innovative multi-omics-based methodologies for the diagnosis and management of nutritional status. The intricate interplay between genetic and environmental factors, in conjunction with nutritional status, occupies a pivotal role in the multifaceted pathogenesis of chronic liver diseases.

Given the intricate and multifaceted nature of the relationship between nutrition and chronic liver diseases, this dedicated Special Issue aims to provide an encompassing platform. Our objective is to elucidate the theoretical underpinnings, practical applications, and clinical relevance of weight management and nutritional strategies within the context of chronic liver diseases, thereby contributing to the advancement of scientific knowledge in this critical domain.

Prof. Dr. Dae Won Jun
Dr. Jun-Hyuk Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nutrients
liver disease
steatotic liver disease
alcohol
fatty liver
over-nutrition
malnutrition
sarcopenia

Published Papers (1 paper)

Research

17 pages, 1558 KiB

Open AccessArticle

Different Associations of Coffee Consumption with the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease and Advanced Liver Fibrosis

by Jun-Hyuk Lee, JooYong Park and Sang Bong Ahn

Nutrients 2024, 16(1), 140; https://doi.org/10.3390/nu16010140 - 31 Dec 2023

Viewed by 1189

Abstract

Although coffee has a potential hepatoprotective effect, evidence of the relationship between coffee consumption and metabolic dysfunction-associated steatotic liver disease (MASLD) remains conflicting. There is limited evidence regarding the most appropriate coffee intake to prevent advanced liver fibrosis (ALF) in patients with MASLD. We investigated the effect of coffee consumption on MASLD and ALF among 5266 participants without MASLD and 1326 with MASLD but without ALF. Participants were grouped by coffee intake: non-consumers, >0 and <1 cups/day, ≥1 and <2 cups/day, and ≥2 cups/day. Over a median follow-up of 11.6 years for MASLD and 15.7 years for ALF, coffee consumption did not significantly affect the incidence of MASLD, with 2298 new cases observed. However, a notable inverse association was found with ALF risk in patients with MASLD among those consuming coffee ≥2 cups/day (adjusted HR 0.57, 95% CI: 0.37–0.90, p = 0.014), especially among those consuming coffee ≥2 and <3 cups/day (adjusted HR 0.51, 95% CI: 0.30–0.89, p = 0.018). This suggests a potential hepatoprotective effect of coffee, especially in preventing the progression of liver fibrosis in patients with MASLD. These findings propose that coffee consumption could be a simple and effective approach to mitigate the risk of ALF in individuals with MASLD. Full article

(This article belongs to the Special Issue Nutrition and Dietary Intake in Liver-Related Diseases)

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