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Special Issue "Inorganic Nitrate/Nitrite in Human Health and Disease"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editor

Guest Editor
Assoc. Prof. Mark McEvoy

Centre for Clinical Epidemiology & Biostatistics, Hunter Medical Research Institute, University of Newcastle, Australia
Website | E-Mail
Interests: chronic disease; epidemiology; nutrition; microbiome; genetics

Special Issue Information

Dear Colleagues,

It is now well established that the human body uses exogenous nitrate/nitrite to synthesise the important messenger molecule, nitric oxide (NO) via the nitrate-nitrite-NO pathway. This is especially important in NO-depletion states, where exogenous nitrate/nitrite may be required in greater amounts to maintain health and prevent disease. Given that nitric oxide possesses many organ protective properties it stands to reason that sufficient NO derived from dietary or non-dietary nitrate sources may offer protection against a number of chronic diseases linked to NO depletion (e.g., cardiovascular disease, metabolic disease, respiratory disease). In the last decade there has been a surge in the number of studies examining the effects of nitrate/nitrite on cardiovascular risk factors, however limited studies have examined the association with hard cardiovascular disease endpoints. Furthermore, few studies have examined the effects of long term nitrate intake and cardiovascular disease. Moreover, an even smaller number of studies have examined any association with other diseases, such as metabolic and respiratory disease.

The purpose of this Special Issue, "Inorganic Nitrate/Nitrite in Human Health and Disease" is three-fold: 1) to address the lack of epidemiological research, in particular, longitudinal analyses, examining the relationship between dietary nitrate/nitrate intake and chronic disease,  2) to address the lack of experimental research in humans between dietary or non-dietary nitrate/nitrate intake and chronic disease risk factors (e.g., blood pressure, blood lipids, endothelial function, arterial stiffness, platelet function, inflammatory markers, fasting serum glucose), and 3) to address the lack of human experimental research examining dietary or non-dietary nitrate/nitrate intake interventions for primary or secondary prevention of chronic disease.

Assoc. Prof. Mark McEvoy

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Inorganic nitrate/nitrite
  • Cardiovascular disease
  • Metabolic disease
  • Respiratory disease
  • Depressive illness
  • Blood pressure
  • Endothelial function
  • Arterial stiffness
  • Platelet function
  • Blood lipids
  • Inflammation
  • Markers of glycaemic control

Published Papers (1 paper)

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Open AccessArticle Dietary Nitrate and Diet Quality: An Examination of Changing Dietary Intakes within a Representative Sample of Australian Women
Nutrients 2018, 10(8), 1005; https://doi.org/10.3390/nu10081005
Received: 5 July 2018 / Revised: 27 July 2018 / Accepted: 31 July 2018 / Published: 1 August 2018
PDF Full-text (255 KB) | HTML Full-text | XML Full-text | Supplementary Files
Dietary nitrate is increasingly linked to a variety of beneficial health outcomes. Our purpose was to estimate dietary nitrate consumption and identify key dietary changes which have occurred over time within a representative sample of Australian women. Women from the 1946–1951 cohort of
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Dietary nitrate is increasingly linked to a variety of beneficial health outcomes. Our purpose was to estimate dietary nitrate consumption and identify key dietary changes which have occurred over time within a representative sample of Australian women. Women from the 1946–1951 cohort of the Australian Longitudinal Study on Women’s Health with complete food frequency questionnaire data for both 2001 and 2013 were included for analysis. Dietary nitrate intakes were calculated using key published nitrate databases. Diet quality scores including the Australian Recommended Food Score, the Mediterranean Diet Score and the Nutrient Rich Foods Index were calculated along with food group serves as per the Australian Dietary Guidelines. Wilcoxon matched pairs tests were used to test for change in dietary intakes and Spearman’s correlations were used to examine associations. In our sample of 8161 Australian women, dietary nitrate intakes were on average 65–70 mg/day, and we detected a significant increase in dietary nitrate consumption over time (+6.57 mg/day). Vegetables were the primary source of dietary nitrate (81–83%), in particular lettuce (26%), spinach (14–20%), beetroot (10–11%), and celery (7–8%) contributed primarily to vegetable nitrate intakes. Further, increased dietary nitrate intakes were associated with improved diet quality scores (r = 0.3, p < 0.0001). Although there is emerging evidence indicating that higher habitual dietary nitrate intakes are associated with reduced morbidity and mortality, future work in this area should consider how dietary nitrate within the context of overall diet quality can facilitate health to ensure consistent public health messages are conveyed. Full article
(This article belongs to the Special Issue Inorganic Nitrate/Nitrite in Human Health and Disease)
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