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Special Issue "Inorganic Nitrate/Nitrite in Human Health and Disease"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 30 September 2018

Special Issue Editor

Guest Editor
Assoc. Prof. Mark McEvoy

Centre for Clinical Epidemiology & Biostatistics, Hunter Medical Research Institute, University of Newcastle, Australia
Website | E-Mail
Interests: chronic disease; epidemiology; nutrition; microbiome; genetics

Special Issue Information

Dear Colleagues,

It is now well established that the human body uses exogenous nitrate/nitrite to synthesise the important messenger molecule, nitric oxide (NO) via the nitrate-nitrite-NO pathway. This is especially important in NO-depletion states, where exogenous nitrate/nitrite may be required in greater amounts to maintain health and prevent disease. Given that nitric oxide possesses many organ protective properties it stands to reason that sufficient NO derived from dietary or non-dietary nitrate sources may offer protection against a number of chronic diseases linked to NO depletion (e.g., cardiovascular disease, metabolic disease, respiratory disease). In the last decade there has been a surge in the number of studies examining the effects of nitrate/nitrite on cardiovascular risk factors, however limited studies have examined the association with hard cardiovascular disease endpoints. Furthermore, few studies have examined the effects of long term nitrate intake and cardiovascular disease. Moreover, an even smaller number of studies have examined any association with other diseases, such as metabolic and respiratory disease.

The purpose of this Special Issue, "Inorganic Nitrate/Nitrite in Human Health and Disease" is three-fold: 1) to address the lack of epidemiological research, in particular, longitudinal analyses, examining the relationship between dietary nitrate/nitrate intake and chronic disease,  2) to address the lack of experimental research in humans between dietary or non-dietary nitrate/nitrate intake and chronic disease risk factors (e.g., blood pressure, blood lipids, endothelial function, arterial stiffness, platelet function, inflammatory markers, fasting serum glucose), and 3) to address the lack of human experimental research examining dietary or non-dietary nitrate/nitrate intake interventions for primary or secondary prevention of chronic disease.

Assoc. Prof. Mark McEvoy

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Inorganic nitrate/nitrite
  • Cardiovascular disease
  • Metabolic disease
  • Respiratory disease
  • Depressive illness
  • Blood pressure
  • Endothelial function
  • Arterial stiffness
  • Platelet function
  • Blood lipids
  • Inflammation
  • Markers of glycaemic control

Published Papers

This special issue is now open for submission.
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