Dietary Regimen and Supplement for Alzheimer's Patients—from Prevention to Treatment
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".
Deadline for manuscript submissions: 5 November 2024 | Viewed by 2282
Special Issue Editors
Interests: natural compounds; antioxidants; neurodegenerative disorders; aging; diabetes
Interests: nutrition; cardiovascular disease; neurodegenerative disorders; antioxidants
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is the most relevant neurodegenerative disorder worldwide. It is an age-related disease and, with the increasing lifespan of the global population, the number of subjects affected is projected to double by 2030. AD is pathologically related to the formation of two kinds of lesions: the amyloid plaque, composed by the association of the neurotoxic peptide Aβ1-42, derived from the cleavage of the APP precursor; and the neurofibrillary tangles, composed mainly by the accumulation of the hyperphosphorylated tau protein. Nowadays, it is not possible to identify a specific causative agent and, thus, AD is considered a multifactorial disease. Among all factors that contribute to the onset of AD, life habits surely have a dramatic impact. Adherence to a healthy diet has been reported to be a protective strategy against neurodegeneration. In particular, the Mediterranean diet has been associated with a reduced risk of developing AD. However, since AD has previously been reported as a multifactorial disease, it should be more appropriate to personalize nutrition depending on the risk factors related to each subject to counteract the development of this neurodegenerative disorder more efficiently.
Dr. Francesca Pacifici
Prof. Dr. Donatella Pastore
Dr. Marco Infante
Guest Editors
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Keywords
- natural compounds
- dietary supplementation
- antioxidants
- sirtuin
- inflammation
- oxidative stress
- autophagy
- gut microbiota
- omega-3 fatty acids
- BDNF