The Role of Lipids and Lipoproteins in Health
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".
Deadline for manuscript submissions: 25 August 2024 | Viewed by 646
Special Issue Editor
Special Issue Information
Dear Colleagues,
Lipids are important for human health as they are carried and transported by lipoproteins to different tissues for normal cellular functions. However, blood lipid imbalance or dyslipidemia is harmful and can lead to various disorders. The most important lipoprotein-related diseases are heart disease and other cardiovascular diseases (CVD), which are the leading causes of death worldwide. There are different categories and types of lipoproteins, each playing a different role in cardiovascular diseases. For example, a key process in the pathogenesis of atherosclerosis, the major cause of heart attacks and peripheral vascular disease, is the accumulation of cholesterol-laden macrophages in the artery wall. Thus, one of the factors greatly increasing the risk of atherosclerotic cardiovascular disease is elevated levels of low-density lipoprotein (LDL), which delivers cholesterol to macrophages. In contrast, clinical, epidemiological, and animal studies have demonstrated a strong inverse relationship between high-density lipoprotein cholesterol (HDL-C) levels and CVD risk, strongly supporting the proposal that HDL is antiatherogenic. However, recent studies demonstrated that HDL functions (particularly cholesterol efflux capacity), HDL particle concentration, and HDL proteome are more important for the antiatherogenic properties of HDL than HDL-C levels.
In addition to cardiovascular diseases, lipoproteins play an important role in many other disorders, especially in diabetes and chronic kidney disease (CKD). Diabetic dyslipidemia is characterized by low HDL-C, elevated triglycerides, and elevated LDL-C, particularly small and dense LDL particles. These lipid changes represent a major link between diabetes and increased cardiovascular risk in diabetic patients. CKD patients also exhibit hypertriglyceridemia and low HDL-C levels; however, their LDL-C levels are mostly normal, as opposed to diabetic patients. Therefore, lower HDL levels in CKD patients might be a reason for the dramatically increased CVD risk and progression of CKD stages.
Despite advances in the study of lipoprotein metabolism, their functions, and their impact on disease over the past a few decades, the causal relationship between lipoproteins and different human diseases, as well as the underlying pathophysiological mechanisms remain unclear.
The purpose of this Special Issue is to publish new original discoveries and review articles to deepen our understanding of the role of different types of lipoproteins in the pathogenesis of various human diseases. It aims to identify innovative therapeutic strategies for the prevention or treatment of these diseases.
Dr. Baohai Shao
Guest Editor
Manuscript Submission Information
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Keywords
- lipids
- lipoproteins
- cholesterol
- high-density lipoprotein (HDL)
- atherosclerosis
- cardiovascular disease (CVD)
- chronic kidney disease
- inflammation
- low-density lipoprotein (LDL)
- metabolic syndrome
- diabetes
- dyslipidemia
