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Metabolomics in Nutrition
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Metabolomics in Nutrition

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: closed (28 April 2019) | Viewed by 25216

Special Issue Editors

Dr. Paul Prenzler

E-Mail Website
Guest Editor
School of Agricultural and Wine Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
Interests: analytical chemistry; polyphenols; antioxidants; aroma compounds
Dr. Danielle Ryan

E-Mail Website
Guest Editor
School of Agricultural and Wine Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia
Interests: metabolomics; chromatography; separation science; natural products

Special Issue Information

Dear Colleagues,

Metabolomics holds great promise for the study of many aspects of human health, ranging from early diagnosis of disease, less invasive diagnostic tests, monitoring of disease progress and recovery, through to the many issues associated with the relationship between diet and health. In this latter domain, metabolomics approaches can reveal inter alia: the difference in micro-nutrients between different sources of food; the interaction of food components with gut microflora; the fate of nutrients in adsorption, metabolism, and excretion; the impact of e.g. plant secondary metabolites on markers of disease/poor health, e.g. reactive oxygen species and their end products. As the range of metabolomics applications grows ever wider, it is timely to bring together the latest research in the field of nutrition and metabolomics in a single issue to present the state-of-the-art approaches along with challenges and emerging new areas. This Special Issue of Nutrients, entitled “Metabolomics in Nutrition”, welcomes the submission of manuscripts describing original research or reviewing the scientific literature on this topic.

Dr. Paul Prenzler
Dr. Danielle Ryan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • blood
  • biophenols
  • biomarkers
  • breath
  • cardiovascular disease
  • cancer
  • diabetes
  • diet
  • feces
  • flavonoids
  • GC-QTOF-MS
  • gut health
  • LC-QTOF-MS
  • lipids
  • mental health
  • metabolic syndrome
  • metabolomics
  • metabonomics
  • micriobiome
  • microbiota metabolism
  • NMR spectroscopy
  • nutrients
  • polyphenols
  • reactive oxygen species
  • serum
  • urine

Published Papers (4 papers)

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Research

14 pages, 2674 KiB  
Article
Potential Nutritional and Metabolomic Advantages of High Fat Oral Supplementation in Pancreatectomized Pancreaticobiliary Cancer Patients
by Bo Kyeong Yun, Mina Song, Ho Kyoung Hwang, Hosun Lee, Song Mi Lee, Chang Moo Kang and Seung-Min Lee
Nutrients 2019, 11(4), 893; https://doi.org/10.3390/nu11040893 - 20 Apr 2019
Cited by 4 | Viewed by 3993
Abstract
We examined the effect of high fat oral nutritional supplement (HFS) on the nutritional status, oral intake, and serum metabolites of postoperative pancreaticobiliary cancer patients. Pancreaticobiliary cancer patients were voluntarily recruited. The HFS group received postoperative oral high fat supplementation (80% of total [...] Read more.
We examined the effect of high fat oral nutritional supplement (HFS) on the nutritional status, oral intake, and serum metabolites of postoperative pancreaticobiliary cancer patients. Pancreaticobiliary cancer patients were voluntarily recruited. The HFS group received postoperative oral high fat supplementation (80% of total calories from fat; n = 12) until discharge; the control group (non-HFS; n = 9) received none. Dietary intake, anthropometry, blood chemistry, nutritional risk index (NRI), and serum metabolites analyzed by liquid chromatography tandem mass spectrometry were evaluated. Overall, cumulative caloric supply via parental and oral/enteral routes were not different between groups. However, oral fat intake, caloric intake, and NRI scores of the HFS group were higher than those of the non-HFS group with increased oral meal consumption. Oral caloric, fat, and meal intakes correlated with NRI scores. Metabolomics analysis identified 195 serum metabolites pre-discharge. Oral fat intake was correlated with 42 metabolites relevant to the glycerophospholipid pathway. Oral high fat-specific upregulation of sphingomyelin (d18:1/24:1), a previously reported pancreatic cancer-downregulated metabolite, and lysophosphatidylcholine (16:0) were associated with NRI scores. Provision of HFS in postoperative pancreatic cancer patients may facilitate the recovery of postoperative health status by increasing oral meal intake, improving nutritional status, and modulating serum metabolites Full article
(This article belongs to the Special Issue Metabolomics in Nutrition)
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17 pages, 3331 KiB  
Article
A Metabolomics Approach to the Identification of Urinary Biomarkers of Pea Intake
by Pedapati S.C. Sri Harsha, Roshaida Abdul Wahab, Catalina Cuparencu, Lars Ove Dragsted and Lorraine Brennan
Nutrients 2018, 10(12), 1911; https://doi.org/10.3390/nu10121911 - 4 Dec 2018
Cited by 15 | Viewed by 5840
Abstract
A significant body of evidence demonstrates that isoflavone metabolites are good markers of soy intake, while research is lacking on specific markers of other leguminous sources such as peas. In this context, the objective of our current study was to identify biomarkers of [...] Read more.
A significant body of evidence demonstrates that isoflavone metabolites are good markers of soy intake, while research is lacking on specific markers of other leguminous sources such as peas. In this context, the objective of our current study was to identify biomarkers of pea intake using an untargeted metabolomics approach. A randomized cross-over acute intervention study was conducted on eleven participants who consumed peas and couscous (control food) in random order. The urine samples were collected in fasting state and postprandially at regular intervals and were further analysed by ultra-performance liquid chromatography coupled to quadrupole time of flight mass spectrometry (UPLC-QTOF-MS). Multivariate statistical analysis resulted in robust Partial least squares Discriminant Analysis (PLS-DA) models obtained for comparison of fasting against the postprandial time points (0 h vs. 4 h, (R2X = 0.41, Q2 = 0.4); 0 h vs. 6 h, ((R2X = 0.517, Q2 = 0.495)). Variables with variable importance of projection (VIP) scores ≥1.5 obtained from the PLS-DA plot were considered discriminant between the two time points. Repeated measures analysis of variance (ANOVA) was performed to identify features with a significant time effect. Assessment of the time course profile revealed that ten features displayed a differential time course following peas consumption compared to the control food. The interesting features were tentatively identified using accurate mass data and confirmed by tandem mass spectrometry (MS using commercial spectral databases and authentic standards. 2-Isopropylmalic acid, asparaginyl valine and N-carbamoyl-2-amino-2-(4-hydroxyphenyl) acetic acid were identified as markers reflecting pea intake. The three markers also increased in a dose-dependent manner in a randomized intervention study and were further confirmed in an independent intervention study. Overall, key validation criteria were met for the successfully identified pea biomarkers. Future work will examine their use in nutritional epidemiology studies. Full article
(This article belongs to the Special Issue Metabolomics in Nutrition)
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14 pages, 1921 KiB  
Article
Molecular Fingerprints of Iron Parameters among a Population-Based Sample
by Anne Kaul, Annette Masuch, Kathrin Budde, Gabi Kastenmüller, Anna Artati, Jerzy Adamski, Henry Völzke, Matthias Nauck, Nele Friedrich and Maik Pietzner
Nutrients 2018, 10(11), 1800; https://doi.org/10.3390/nu10111800 - 19 Nov 2018
Cited by 3 | Viewed by 4580
Abstract
Iron deficiency is the most frequent deficiency disease and parameters of iron metabolism appear to be linked to major metabolic and cardiovascular diseases. We screened a large set of small molecules in plasma for associations with iron status among apparently healthy subjects to [...] Read more.
Iron deficiency is the most frequent deficiency disease and parameters of iron metabolism appear to be linked to major metabolic and cardiovascular diseases. We screened a large set of small molecules in plasma for associations with iron status among apparently healthy subjects to elucidate subclinical profiles which may provide a link between iron status and onset of diseases. Based on mass spectrometry and nuclear magnetic resonance spectroscopy we determined 613 plasma metabolites and lipoprotein subfractions among 820 apparently healthy individuals. Associations between ferritin, transferrin, haemoglobin and myoglobin and metabolite levels were tested by sex-specific linear regression analyses controlling for common confounders. Far more significant associations in women (82 out of 102) compared to men became obvious. The majority of the metabolites associated with serum ferritin and haemoglobin in women comprising fatty acid species, branched-chain amino acid catabolites and catabolites of heme. The latter was also obvious among men. Positive associations between serum transferrin and VLDL and IDL particle measures seen in women were observed in men with respect to serum ferritin. We observed a sexual-dimorphic fingerprint of surrogates of iron metabolism which may provide a link for the associations between those parameters and major metabolic and cardiovascular disease. Full article
(This article belongs to the Special Issue Metabolomics in Nutrition)
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13 pages, 1898 KiB  
Article
Ingestion of Insect Protein Isolate Enhances Blood Amino Acid Concentrations Similar to Soy Protein in A Human Trial
by Mathias T. Vangsoe, Rebekka Thogersen, Hanne C. Bertram, Lars-Henrik L. Heckmann and Mette Hansen
Nutrients 2018, 10(10), 1357; https://doi.org/10.3390/nu10101357 - 22 Sep 2018
Cited by 42 | Viewed by 9953
Abstract
Background: Increased amino acid availability stimulates muscle protein synthesis (MPS), which is critical for maintaining or increasing muscle mass when combined with training. Previous research suggests that whey protein is superior to soy protein in regard to stimulating MPS and muscle mass. Nevertheless, [...] Read more.
Background: Increased amino acid availability stimulates muscle protein synthesis (MPS), which is critical for maintaining or increasing muscle mass when combined with training. Previous research suggests that whey protein is superior to soy protein in regard to stimulating MPS and muscle mass. Nevertheless, with respect to a future lack of dietary protein and an increasing need for using eco-friendly protein sources it is of great interest to investigate the quality of alternative protein sources, like insect protein. Objective: Our aim was to compare the postprandial amino acid (AA) availability and AA profile in the blood after ingestion of protein isolate from the lesser mealworm, whey isolate, and soy isolate. Design: Six healthy young men participated in a randomized cross-over study and received three different protein supplementations (25 g of crude protein from whey, soy, insect or placebo (water)) on four separate days. Blood samples were collected at pre, 0 min, 20 min, 40 min, 60 min, 90 min, and 120 min. Physical activity and dietary intake were standardized before each trial, and participants were instructed to be fasting from the night before. AA concentrations in blood samples were determined using 1H NMR spectroscopy. Results: A significant rise in blood concentration of essential amino acids (EAA), branched-chain amino acids (BCAA) and leucine was detected over the 120 min period for all protein supplements. Nevertheless, the change in AA profile was significantly greater after ingestion of whey than soy and insect protein (p < 0.05). Area under the curve (AUC) analysis and AA profile revealed comparable AA concentrations for soy and insect protein, whereas whey promoted a ~97% and ~140% greater AUC value than soy and insect protein, respectively. A tendency towards higher AA concentrations beyond the 120 min period was observed for insect protein. Conclusion: We report that ingestion of whey, soy, and insect protein isolate increases blood concentrations of EAA, BCAA, and leucine over a 120 min period (whey > insect = soy). Insect protein induced blood AA concentrations similar to soy protein. However, a tendency towards higher blood AA concentrations at the end of the 120 min period post ingestion was observed for insect protein, which indicates that it can be considered a “slow” digestible protein source. Full article
(This article belongs to the Special Issue Metabolomics in Nutrition)
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