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The Mechanisms of Nutrient-Nutrient Interactions in Protection from Disease

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 April 2023) | Viewed by 7238

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Dr. Zumin Shi

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Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar
Interests: dietary pattern; micronutrients; epidemiology; anemia; obesity; diabetes; biostatistics and cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

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Dear Colleagues,

Nutrient-nutrient interaction is common. However, the mechanisms are not fully clear. Over the past several decades, a great focus had been put on the impact of one nutrient on other nutrients’ bioavailability via absorption and utilization. The interaction may also happen when nutrients have opposite physiological effects, for example, pro-inflammation and anti-inflammation. A growing number of studies suggest that gut microbiota play an important in the aetiology of many diseases. Different effects of nutrients on gut microbiota may be potential mechanisms of nutrient-nutrient interaction. A better understanding of the mechanisms of nutrient-nutrient interaction may provide valuable information for the prevention of many non-communicable chronic diseases.

In this special issue, we welcome the submission of original research articles and reviews (systematic reviews, critical reviews and meta-analyses).

Prof. Dr. Zumin Shi
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nutrient
interaction
health
diet
inflammation
gut microbiota
bioavailability

Published Papers (3 papers)

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Research

12 pages, 828 KiB

Open AccessArticle

Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005–2016

by Ming Li and Zumin Shi

Nutrients 2022, 14(24), 5345; https://doi.org/10.3390/nu14245345 - 16 Dec 2022

Cited by 5 | Viewed by 2480

Abstract

The association between intakes of riboflavin and mortality has not been examined intensively in general populations. In this study, 10,480 adults in the 2005–2016 National Health and Nutrition Examination Survey (NHANES) were followed-up until 2019 for their vital status. Riboflavin and folate were assessed by two-day 24 h recall. The date and cause of death were obtained from the US Mortality Registry. The risks of all-cause mortality and cardiovascular disease (CVD) mortality were investigated using a Cox regression analysis. During a mean of 8.5 years follow-up, there were 1214 deaths registered (including 373 deaths from CVD and 302 from cancer). Compared to low level (quartile 1, Q1) of riboflavin intake, the hazard ratios (HRs) (95% confidence interval (CI)) for high level (quartile 4, Q4) were 0.53 (0.31–0.90) for CVD mortality and 0.62 (0.48–0.81) for all-cause mortality. The inverse association between riboflavin intake and CVD mortality was only significant among those with a high intake of folate (p for interaction 0.045). Those with a high folate intake (Q4) and low intake of riboflavin (Q1) had the highest risk of CVD mortality (HR 4.38, 95% CI 1.79–10.72), as compared with a high intake of both riboflavin and folate. In conclusion, riboflavin intake was inversely associated with all-cause mortality and CVD mortality, and the association was modified by folate intake. Full article

(This article belongs to the Special Issue The Mechanisms of Nutrient-Nutrient Interactions in Protection from Disease)

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13 pages, 604 KiB

Open AccessArticle

Interactive Effects of Methionine and Lead Intake on Cognitive Function among Chinese Adults

by Xiaomin Sun, Zhongying Li, Yingxin Chen, Tao Xu, Jing Shu, Lin Shi and Zumin Shi

Nutrients 2022, 14(21), 4561; https://doi.org/10.3390/nu14214561 - 29 Oct 2022

Cited by 1 | Viewed by 1336

Abstract

The association between methionine intake and cognitive function is inconclusive. We aimed to assess the association between methionine intake and cognitive function in Chinese adults and to explore the interaction between methionine and lead intake. Data from 4852 adults aged ≥55 years from the China Health and Nutrition Survey were used. Cognitive function was measured in 1997, 2000, 2004, and 2006. A 3-day, 24-hour recall was used to assess methionine and lead intake from different protein sources. Multivariable mixed linear regression was used in the analyses. Total methionine intake was positively correlated with cognition. There was a significant interaction between animal methionine and lead intakes. In subgroup analyses, across the quartiles of animal methionine intake, the regression coefficients (95% CI) for global cognition were 0.00, 0.57 (0.17 to 0.98), 1.18 (0.73 to 1.62), and 1.80 (1.31 to 2.29), respectively, while they were 0.00, −0.73 (−1.12 to −0.34), −0.83 (−1.26 to −0.41), and −1.72 (−2.22 to −1.22) across the quartiles of plant methionine intake, respectivelyThe association between animal methionine intake and cognition was stronger among adults with a low lead intake. In conclusion, animal methionine and plant methionine intake were positively and inversely associated with cognition, respectively. Lead intake modified the association between animal methionine intake and cognition. Full article

(This article belongs to the Special Issue The Mechanisms of Nutrient-Nutrient Interactions in Protection from Disease)

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13 pages, 773 KiB

Open AccessArticle

Selenium Intake and its Interaction with Iron Intake Are Associated with Cognitive Functions in Chinese Adults: A Longitudinal Study

by Ke Jiang, Changxiao Xie, Zhourong Li, Huan Zeng, Yong Zhao and Zumin Shi

Nutrients 2022, 14(15), 3005; https://doi.org/10.3390/nu14153005 - 22 Jul 2022

Cited by 7 | Viewed by 1944

Abstract

Studies on the relation between selenium intake and cognitive function are inconclusive. This study aimed to examine the associations between dietary selenium intake and cognitive function among Chinese adults and tested the interaction effect of selenium intake and iron intake on cognition. Data from 4852 adults aged 55 years and above who attended the 1991–2006 China Health and Nutrition Survey (CHNS) were used. Cognitive function was assessed through face-to-face interviews in 1997, 2000, 2004, and 2006. A 3-day, 24-hour recall was used to collect dietary selenium intake. Multivariable mixed linear regression and logistic regression were used in the analyses. In fully adjusted regression models, the regression coefficients (95% confidence interval) were 0.00, 0.29 (−0.12–0.70), 0.26 (−0.18–0.70), and 0.50 (0.02–0.97) across the quartiles of selenium intake. In the subgroup analysis, the positive association between selenium intake and cognitive function was only observed in the participants who live in the southern region but not those in the northern region. The selenium-intake-to-iron-intake ratio was inversely associated with low global cognition scores. Furthermore, only those with a normal BMI had a positive association between selenium and cognition. In conclusion, high selenium intake was linked to better cognitive function and a lower risk of cognition decline in Chinese adults among those with low iron intake. A substantial interaction was found between selenium intake and BMI or region. Full article

(This article belongs to the Special Issue The Mechanisms of Nutrient-Nutrient Interactions in Protection from Disease)

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