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Nutrients
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Regulation of Cellular Metabolism by Nutrient Sensing Pathways
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Regulation of Cellular Metabolism by Nutrient Sensing Pathways

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 8183

Special Issue Editors

Dr. Peter Zahradka

E-Mail Website
Guest Editor
Department of Physiology and Pathophysiology, Rady School of Medicine, Faculty of Health Sciences, University of Manitoba, and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
Interests: metabolic dysfunction; vascular disease; endothelial cells; vascular smooth muscle cells; post-translational modifications; adipokines; cell phenotype; insulin signaling; clinical trials
Dr. Carla G. Taylor

E-Mail Website
Guest Editor
Department of Human Nutritional Sciences, Faculty of Agriculture and Food Science, University of Manitoba, and Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Albrechtsen Research Centre, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
Interests: nutrition; dietary interventions; obesity; diabetes; metabolic syndrome; adipocyte dysfunction; hepatic steatosis; immune defense; cell signaling
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In multicellular organisms, fluctuations in nutrient availability can influence an individual cell's metabolic homeostasis. Consequently, it is critical for a cell to be able to perceive its external and internal environment. Cells respond to energy states, macronutrients and micronutrients, and their metabolites. To do this effectively, cells have developed various systems that can sense these various molecules. Modulation of cellular metabolism can be achieved through mechanisms involving receptors, transporters and binding proteins, transcription factors, post-transcriptional regulation, post-translational modifications, feedback regulation of enzyme activity, protein–protein interactions, and nutrient structure. The intent of this Special Issue is to increase our knowledge of specialized sensing mechanisms and associated signaling pathways by which cellular metabolism is regulated in response to nutrients and how these processes contribute to metabolic homeostasis or dysfunction in various cell types.

Dr. Peter Zahradka
Dr. Carla G. Taylor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Signal transduction
  • Receptors
  • Lipid sensing
  • Carbohydrate responsive
  • Gene expression
  • Post-translational modifications
  • Catabolic and anabolic pathways
  • Therapeutic applications

Published Papers (2 papers)

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Research

12 pages, 1069 KiB  
Article
Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study
by Maria C Patino-Alonso, Marta Gómez Sánchez, Leticia Gómez Sánchez, Rosario Alonso-Domínguez, Natalia Sánchez-Aguadero, Benigna Sánchez Salgado, Emiliano Rodríguez Sánchez, Luis García Ortiz and Manuel A Gómez-Marcos
Nutrients 2020, 12(3), 643; https://doi.org/10.3390/nu12030643 - 28 Feb 2020
Cited by 1 | Viewed by 2136
Abstract
The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of [...] Read more.
The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of vitamin intake in a sample of the Spanish population without previous cardiovascular disease and analyze the differences according to sex. Methods: We included 501 individuals obtained by simple random sampling with replacement (reference population 43,946). The average age was 55.90 ± 14.24 years, 49.70% men. Participants recorded the intake of vitamins using the EVIDENT app, previously validated, during a period of 3 days. Vascular function was assessed by measuring carotid-femoral pulse wave velocity (cfPWV) with the SphygmoCor device, cardio-ankle vascular index (CAVI) with the VaSera device and brachial-ankle pulse wave velocity (baPWV) by using a validated equation. Results: The vitamins with the least adequate intake was vitamin D, less than 5%, and vitamin B9, less than 35%. Vitamins with an adequate intake percentage, close to 100%, were B12 and B6. The multiple regression analysis showed a negative association between cfPWV and vitamin B2 in both sexes, and a positive one with retinol in men and B3 in women. baPWV was negatively associated with vitamins B1 and B12 in women and B9 in men, while being positively linked with B6 in men. CAVI presented a negative association with vitamin D in women. The results were similar in the canonical correspondence analysis. In conclusion, the results of this study suggest that the influence of vitamins on vascular function is not homogeneous and varies according to the parameter analyzed. Thus, in men, vitamins B2 and retinol were associated with cfPWV and vitamins B6 and B9 with baPWV. In women, vitamins B2 and B3 were related cfPWV, vitamins B1 and B12 with cfPWV and vitamin D with CAVI. Full article
(This article belongs to the Special Issue Regulation of Cellular Metabolism by Nutrient Sensing Pathways)
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18 pages, 2383 KiB  
Article
ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling
by Samantha A Hutchinson, Priscilia Lianto, Hanne Roberg-Larsen, Sebastiano Battaglia, Thomas A Hughes and James L Thorne
Nutrients 2019, 11(11), 2618; https://doi.org/10.3390/nu11112618 - 01 Nov 2019
Cited by 12 | Viewed by 5626
Abstract
Interventions that alter cholesterol have differential impacts on hormone receptor positive- and negative-breast cancer risk and prognosis. This implies differential regulation or response to cholesterol within different breast cancer subtypes. We evaluated differences in side-chain hydroxycholesterol and liver X nuclear receptor signalling between [...] Read more.
Interventions that alter cholesterol have differential impacts on hormone receptor positive- and negative-breast cancer risk and prognosis. This implies differential regulation or response to cholesterol within different breast cancer subtypes. We evaluated differences in side-chain hydroxycholesterol and liver X nuclear receptor signalling between Oestrogen Receptor (ER)-positive and ER-negative breast cancers and cell lines. Cell line models of ER-positive and ER-negative disease were treated with Liver X Receptor (LXR) ligands and transcriptional activity assessed using luciferase reporters, qPCR and MTT. Publicly available datasets were mined to identify differences between ER-negative and ER-positive tumours and siRNA was used to suppress candidate regulators. Compared to ER-positive breast cancer, ER-negative breast cancer cells were highly responsive to LXR agonists. In primary disease and cell lines LXRA expression was strongly correlated with its target genes in ER-negative but not ER-positive disease. Expression of LXR’s corepressors (NCOR1, NCOR2 and LCOR) was significantly higher in ER-positive disease relative to ER-negative, and their knock-down equalized sensitivity to ligand between subtypes in reporter, gene expression and viability assays. Our data support further evaluation of dietary and pharmacological targeting of cholesterol metabolism as an adjunct to existing therapies for ER-negative and ER-positive breast cancer patients. Full article
(This article belongs to the Special Issue Regulation of Cellular Metabolism by Nutrient Sensing Pathways)
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