nutrients-logo

Journal Browser

Journal Browser

Diet for Stroke

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (1 July 2020) | Viewed by 9494

Special Issue Editor


E-Mail Website
Guest Editor
1. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
2. Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
3. Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, 00166 Rome, Italy
Interests: neuroprotection; vascular diseases; aging; genetics; epidemiology; metabolic disorders; antioxidants; nutrition in vascular diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Stroke is the second leading cause of death and the third leading cause of disability worldwide. Unfortunately, the incidence of stroke has risen exponentially in recent decades, especially in Western countries. Therefore, the development of effective preventive strategies to counteract this pandemic is urgently needed. The major known risk factors for stroke are hypertension, diabetes, and dyslipidaemia. However, recently, significant attention has been given to the impact of lifestyle on the risk for stroke, in particular, the importance of diet. Diet directly effects the stroke risk factors through the maintenance of body weight. Moreover, a direct effect of diet on stroke risk has been reported, and it has been estimated that a healthy diet reduces stroke risk by more than 19%. The pleiotropic effects of diet against stroke may be related to the presence of nutrients with anti-inflammatory and antioxidant properties in certain foods. The Mediterranean diet has been associated with better cardiovascular health, including a lower risk for stroke. The presence of some specific nutrients, like omega-3 fatty acids, polyphenols, and vitamins, have been strongly associated with primary and secondary prevention of stroke. Moreover, recently a nutrigenomics interaction between dietary change, vascular risk factors, and risk for stroke was proposed. The main objective of this Special Issue, Diet for Stroke, is to publish selected papers on the roles of macro- and micronutrients on risk factors for stroke. Authors are invited to submit proposals for manuscripts that fit this objective. Clinical or experimental studies and/or review will be considered.

Dr. David Della-Morte
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • cerebrovascular diseases
  • atherosclerosis
  • polyphenols
  • omega-3 PUFAs
  • nutrigenomics
  • antioxidants
  • inflammation
  • preventive strategies

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Jump to: Other

15 pages, 700 KiB  
Review
Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment
by Francesca Pacifici, Valentina Rovella, Donatella Pastore, Alfonso Bellia, Pasquale Abete, Giulia Donadel, Silvia Santini, Heinz Beck, Camillo Ricordi, Nicola Di Daniele, Davide Lauro and David Della-Morte
Nutrients 2021, 13(6), 1967; https://doi.org/10.3390/nu13061967 - 8 Jun 2021
Cited by 12 | Viewed by 5613
Abstract
Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural [...] Read more.
Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascular diseases and IS have been investigated for a long time. In this article, we reviewed the association between the most studied polyphenols and stroke protection in terms of prevention, effect on acute phase, and rehabilitation. We described experimental and epidemiological studies reporting the role of flavonols, phenolic acid, and stilbens on ischemic mechanisms leading to stroke. We analyzed the principal animal models used to evaluate the impact of these micronutrients to cerebral blood flow and to molecular pathways involved in oxidative stress and inflammation modulation, such as sirtuins. We reported the most significant clinical trials demonstrated as the persistent use of polyphenols is clinically relevant in terms of the reduction of vascular risk factors for IS, such as Atrial Fibrillation. Interestingly, different kinds of polyphenols provide brain protection by activating different pathways and mechanisms, like inducing antithrombotic effect, such as Honokiol. For this reason, we discussed an appropriate integrative use of them as a possible therapeutic alternative against stroke. Full article
(This article belongs to the Special Issue Diet for Stroke)
Show Figures

Figure 1

Other

Jump to: Review

7 pages, 226 KiB  
Brief Report
Dietary and Serum Omega-6/Omega-3 Fatty Acids Are Associated with Physical and Metabolic Function in Stroke Survivors
by Monica C. Serra, Alice S. Ryan, Charlene E. Hafer-Macko, Manuel Yepes, Fadi B. Nahab and Thomas R. Ziegler
Nutrients 2020, 12(3), 701; https://doi.org/10.3390/nu12030701 - 6 Mar 2020
Cited by 5 | Viewed by 3317
Abstract
The purpose of this study was to quantify habitual dietary and systemic omega-6 and omega-3 fatty acids and their ratios and to determine their relationship with physical and metabolic function in a cohort of chronic adult stroke survivors. Twenty-five older chronic stroke survivors [...] Read more.
The purpose of this study was to quantify habitual dietary and systemic omega-6 and omega-3 fatty acids and their ratios and to determine their relationship with physical and metabolic function in a cohort of chronic adult stroke survivors. Twenty-five older chronic stroke survivors (age: 63 ± 8 years; BMI: 31 ± 7 kg/m2; mean ± SD) were assessed for fitness (VO2peak), gait speed (GS), 3 m timed up and go (TUG), and six-minute walk distance (6MWD). Plasma lipid and glucose profiles were measured, and HOMA-IR calculated. Dietary (5-day food records) and serum (mass spectrometry) omega-6/omega-3 profiles were assessed. Participants were severely deconditioned (VO2peak: 19 ± 4 mL/kg/min; GS: 0.88 ± 0.28 m/s; TUG: 12.6 ± 5.9 s; 6MWD: 295 ± 121 m) and at elevated metabolic risk (HOMA-IR: 6.3 ± 4.5). The dietary intake ratio of omega-6/omega-3 fatty acids averaged 12.6 ± 7.1 and the serum concentration ratio was 1.21 ± 0.37, which were correlated (r = 0.88, p < 0.01). Higher dietary intake and serum concentrations of omega-6/omega-3 fatty acids were associated with lower 6MWD and higher HOMA-IR, while a higher serum omega-6/omega-3 concentration index was associated with lower VO2peak (p’s < 0.05). These preliminary data suggest that both dietary omega-6 and omega-3 fatty acids (quantitated as their intake ratio) and the serum concentration ratio of omega-6/omega-3 may be important indices of physical dysfunction and insulin resistance in chronic stroke survivors. Full article
(This article belongs to the Special Issue Diet for Stroke)
Back to TopTop