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Diet and Nutrition in Neuropathic Pain and Headache

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 23763

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Special Issue Editors

Dr. Panagiotis Zis

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Guest Editor

Medical School, University of Cyprus, 2029 Nicosia, Cyprus
Interests: immune ataxias; gluten ataxia; gluten neuropathy; coeliac disease; neurological manifestations of gluten sensitivity; peripheral neuropathies
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Marios Hadjivassiliou

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Guest Editor

Academic Department of Neurosciences, University of Sheffield, Sheffield S10 2JF, UK
Interests: ataxias; neurological manifestations of coeliac disease and gluten sensitivity
Special Issues, Collections and Topics in MDPI journals

Dr. Dimos-Dimitrios Mitsikostas

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Guest Editor

First Neurology Department, Medical School, Aeginition Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: headache; migraine; pathophysiology; chronic migraine, treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The overlap between nutrition and neurological diseases is evident. Specific diets might lead to neurological manifestations, worsen pre-existing neurological problems or protect from developing ones.

In this Special Issue, we welcome papers focusing on the links between diet and nutrition and neuropathic pain, as well as headache of any type. We welcome original papers, reviews and meta-analyses with a particular interest in the role of specific nutrients in the pathogenesis and the natural history of neuropathic pain and headaches of any type.

These include, but are not limited to the following:

Pain and vitamin deficiencies
Pain and vitamin excesses
Gluten related pain
Lactose related pain
Vegan diet and pain
Vegetarian diet and pain
Headache and vitamin deficiencies
Headache and vitamin excesses
Gluten related headache
Lactose related headache
Vegan diet and headache
Vegetarian diet and headache

Dr. Panagiotis Zis
Prof. Marios Hadjivassiliou
Dr. Dimos-Dimitrios Mitsikostas
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Neuropathic pain
Headache
Nutrition
Diet
Vitamin deficiency
Gluten sensitivity
Coeliac disease
Malabsorption

Published Papers (3 papers)

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Research

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15 pages, 726 KiB

Open AccessArticle

Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia

by Li-Kai Wang, Yao-Tsung Lin, Kuo-Chuan Hung, Chia-Yu Chang, Zhi-Fu Wu, Miao-Lin Hu and Jen-Yin Chen

Nutrients 2020, 12(8), 2384; https://doi.org/10.3390/nu12082384 - 09 Aug 2020

Cited by 6 | Viewed by 4270

Abstract

Vitamin C deficiency increases the risk of postherpetic neuralgia (PHN). In this cross-sectional study, the relationships among plasma vitamin C concentrations, pain and Leeds assessment of neuropathic symptoms and signs (LANSS) items were investigated during their first pain clinic visit of 120 PHN patients. The factors associated with vitamin C deficiency were determined. Independent predictors of vitamin C deficiency were presented as adjusted odds ratios (AOR) and 95% confidence intervals (CI). The patients had a high prevalence (52.5%) of vitamin C deficiency. Their plasma vitamin C concentrations were negatively associated with spontaneous pain and tingling, prickling or pins and needles sensation according to the LANSS questionnaire. Based on the receiver operator characteristic curve, the cutoffs for plasma vitamin C to predict moderate-to-severe and severe symptoms of sharp sensation were <7.05 and <5.68 mg/L, respectively. By comparison, the patients well-nourished with vitamin C had lower incidences of sharp sensations, sharp pain, and reddish skin. Multivariate analyses revealed that vitamin C deficiency was associated with the low intake of fruit/vegetables (AOR 2.66, 95% CI 1.09–6.48, p = 0.032), peptic ulcer disease (AOR 3.25, 95% CI 1.28–8.28, p = 0.014), and smoking (AOR 3.60, 95% CI 1.33–9.77, p = 0.010). Future studies are needed to substantiate these findings. Full article

(This article belongs to the Special Issue Diet and Nutrition in Neuropathic Pain and Headache)

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9 pages, 234 KiB

Open AccessArticle

Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy. A Pilot Open-Label Consecutive Case Series Study

by Michael L. Rosenberg, Vahid Tohidi, Karna Sherwood, Sujoy Gayen, Rosina Medel and Gad M. Gilad

Nutrients 2020, 12(2), 576; https://doi.org/10.3390/nu12020576 - 23 Feb 2020

Cited by 12 | Viewed by 7814

Abstract

Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evidence, we conducted an open-label consecutive case series study to evaluate the effectiveness of agmatine in neuropathies associated with painful SFN (Study Registry: ClinicalTrials.gov, System Identifier: NCT01524666). Participants diagnosed with painful SFN and autonomic dysfunctions were treated with 2.67 g/day agmatine sulfate (AgmaSet^® capsules containing G-Agmatine^® brand of agmatine sulfate) for a period of 2 months. Before the beginning (baseline) and at the end of the treatment period, participants answered the established 12-item neuropathic pain questionnaire specifically developed to distinguish symptoms associated with neuropathy and to quantify their severity. Secondary outcomes included other treatment options and a safety assessment. Twelve patients were recruited, and 11 patients—8 diagnosed with diabetic neuropathy, two with idiopathic neuropathy and one with inflammatory neuropathy—completed the study. All patients showed improvement in neuropathic pain to a varied extent. The average decrease in pain intensity was 26.0 rating points, corresponding to a 46.4% reduction in overall pain (p < 0.00001). The results suggest that dietary agmatine sulfate has a significant effect in reducing neuropathic pain intensity associated with painful SFN resistant to treatment with conventional neuropathic pain medications. Larger randomized placebo-controlled studies are expected to establish agmatine sulfate as a preferred treatment. Full article

(This article belongs to the Special Issue Diet and Nutrition in Neuropathic Pain and Headache)

Review

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16 pages, 587 KiB

Open AccessReview

B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review

by Thomas Julian, Rubiya Syeed, Nicholas Glascow, Efthalia Angelopoulou and Panagiotis Zis

Nutrients 2020, 12(8), 2221; https://doi.org/10.3390/nu12082221 - 25 Jul 2020

Cited by 38 | Viewed by 11069

Abstract

Neuropathic pain describes a range of unpleasant sensations caused by a lesion or disease of the somatosensory nervous system. The sensations caused by neuropathic pain are debilitating and improved treatment regimens are sought in order to improve the quality of life of patients. One proposed treatment for neuropathic pain is vitamin B12, which is thought to alleviate pain by a number of mechanisms including promoting myelination, increasing nerve regeneration and decreasing ectopic nerve firing. In this paper, the evidence for B12 as a drug treatment for neuropathic pain is reviewed. Twenty four published articles were eligible for inclusion in this systematic review in which a range of treatment regimens were evaluated including both B12 monotherapy and B12 in combination with other vitamins or conventional treatments, such as gabapentinoids. Overall, this systematic review demonstrates that there is currently some evidence for the therapeutic effect of B12 in the treatment of post-herpetic neuralgia (level II evidence) and the treatment of painful peripheral neuropathy (level III evidence). Full article

(This article belongs to the Special Issue Diet and Nutrition in Neuropathic Pain and Headache)

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