Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.1
4.3
Journals
Pharmaceuticals
Special Issues
Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application...
share announcement

Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 8114

Special Issue Editors

Prof. Dr. Cinzia Anna Ventura

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Interests: drug delivery; drug/cyclodextrin inclusion complexes; polymeric nanoparticles; cancer diseases; antimicrobial drugs; Alzheimer’s disease
Special Issues, Collections and Topics in MDPI journals
Dr. Federica De Gaetano

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, Italy
Interests: drug delivery; cyclodextrin; drug/cyclodextrin inclusion complexes; nanoparticles; nanostructures; supramolecular chemistry; anticancer therapy; antibacterial therapy; neurodegenerative disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceuticals is planning to publish a Special Issue titled “Cyclodextrin-Based Drug Delivery System and its Pharmaceutical and Biomedical Application”, and I am cordially inviting you to contribute your communications, research articles or high-quality review papers.  

Cyclodextrins have long received a great deal of interest from the scientific community for their versatility and possibile applications in various fields of science. They are cyclic oligosaccharides produced by the enzymatic degradation of starch and characterized by a hydrophobic internal cavity and a hydrophilic external surface. This architecture allows for the possibility of encapsulating various substances, thus improving their physicochemical properties. Cyclodextrins are the pioneers of supramolecular carriers and are used in the pharmaceutical field for their ability to solubilize lipophilic drugs, enhancing their biological effects. Mixed supramolecular carriers, consisting of cyclodextrins in polymeric nanoparticles or cyclodextrins in liposomes, exhibit improved encapsulation parameters and controlled drug release, compared to the corresponding carrier without macrocycles. Different chemical modifications can be made on the free hydroxyl groups of cyclodextrins, producing derivatives with greater water solubility than native cyclodextrins and in some cases with excellent mucoadhesive properties able to increase drug permeation through the mucosae. Nanostructured systems based on polymeric cyclodextrins show low toxicity, good bioavailability and biodegradability, and can be used in a wide range of biomedical applications, from erodible hydrogels for regenerative medicine to targeted drug and gene delivery.

This Special Issue intends to host research and review papers on the development of novel cyclodextrin-based drug delivery systems performed in the scientific areas of pharmaceutical technology, chemistry, physics, and biology. Areas of interest include, but are not limited to, drug–cyclodextrin interactions, cyclodextrin-based nanoparticles, cyclodextrin in liposomes, cyclodextrins as drugs, cyclodextrin dimers and polymers, biological in vitro/ex vivo/in vivo evaluation of cyclodextrin-based formulations, cyclodextrin–cell interactions, cyclodextrin-based hydrogels, and regenerative medicine.

Prof. Dr. Cinzia Anna Ventura
Dr. Federica De Gaetano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • inclusion complexes
  • polymeric cyclodextrins
  • nanostructurated carriers
  • polyrotaxanes
  • nanosponges
  • chemical–physical characterization
  • in vitro/ex vivo/in vivo evaluation
  • theranostic
  • regenerative medicine
  • gene delivery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

18 pages, 2822 KiB  
Article
Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium
by Betzaida Castillo Cruz, Sandra Chinapen Barletta, Bryan G. Ortiz Muñoz, Adriana S. Benitez-Reyes, Omar A. Amalbert Perez, Alexander C. Cardona Amador, Pablo E. Vivas-Mejia and Gabriel L. Barletta
Pharmaceuticals 2024, 17(10), 1344; https://doi.org/10.3390/ph17101344 - 8 Oct 2024
Viewed by 548
Abstract
Background: Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and in vivo. However, the liposome’s fluid-phospholipid bilayer of liposomes allows siRNA fragments to diffuse out of the liposome, decreasing the dose concentration and [...] Read more.
Background: Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and in vivo. However, the liposome’s fluid-phospholipid bilayer of liposomes allows siRNA fragments to diffuse out of the liposome, decreasing the dose concentration and therefore the effectiveness of the carrier. We have previously reported that β-cyclodextrins formulated in liposomes help increase the stability of siRNAs in cell culture medium. Here, we continued that study to include α, γ, methyl-β-cyclodextrins and β-cyclodextrin-modified gold and selenium nanoparticles. Methods: We used Isothermal Titration Calorimetry to study the binding thermodynamics of siRNAs to the cyclodextrin-modified nanoparticles and to screen for the best adamantane derivative to modify the siRNA fragments, and we used gel electrophoresis to study the stabilization effect of siRNA by cyclodextrins and the nanoparticles. Results: We found that only β- and methyl-β-cyclodextrins increased siRNA serum stability. Cyclodextrin-modified selenium nanoparticles also stabilize siRNA fragments in serum, and siRNAs chemically modified with an adamantane moiety (which forms inclusion complexes with the cyclodextrin-modified-nanoparticles) show a strong stabilization effect. Conclusions: β-cyclodextrins are good additives to stabilize siRNA in cell culture medium, and the thermodynamic data we generated of the interaction between cyclodextrins and adamantane analogs (widely used in drug delivery studies), should serve as a guide for future studies where cyclodextrins are sought for the delivery and solvation of small organic molecules. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024)
►▼ Show Figures

Figure 1

23 pages, 6892 KiB  
Article
Enhancement of Cognitive Function by Andrographolide-Loaded Lactose β-Cyclodextrin Nanoparticles: Synthesis, Optimization, and Behavioural Assessment
by Debashish Paramanick, Kagithala Naga Rani, Vijay Kumar Singh, Parakh Basist, Rahmuddin Khan, Jameel H. Al-Tamimi, Omar M. Noman, Mansour N. Ibrahim and Abdulsalam Alhalmi
Pharmaceuticals 2024, 17(7), 966; https://doi.org/10.3390/ph17070966 - 21 Jul 2024
Cited by 1 | Viewed by 1152
Abstract
This study investigates whether Andrographolide-loaded Lactose β-Cyclodextrin (ALN-βCD) nanoparticles enhance cognitive function, particularly spatial learning and memory. The successful conjugation of lactose to β-cyclodextrin was confirmed via 1H NMR spectroscopy, facilitating neuronal cell entry. The solvent evaporation method was used to create the [...] Read more.
This study investigates whether Andrographolide-loaded Lactose β-Cyclodextrin (ALN-βCD) nanoparticles enhance cognitive function, particularly spatial learning and memory. The successful conjugation of lactose to β-cyclodextrin was confirmed via 1H NMR spectroscopy, facilitating neuronal cell entry. The solvent evaporation method was used to create the nanoparticles, which were characterised for particle size, PDI, zeta potential, and drug release. The nanoparticles exhibited a size of 247.9 ± 3.2 nm, a PDI of 0.5 ± 0.02, and a zeta potential of 26.8 ± 2.5 mV. FTIR and TEM analyses, along with in vitro drug release and BBB permeability studies, confirmed their stability and efficacy. Behavioural tests, including the Elevated Plus Maze, Y-Maze, Object Recognition, and Locomotor Activity tests, demonstrated significant improvements in memory, motor coordination, and exploration time in the nanoparticle-treated groups. The group treated with ALN-βCD at a dose of 100 mg/kg/p.o. showed superior cognitive performance compared to the group receiving free andrographolides (AG). Biochemical assays indicated a significant reduction in acetylcholinesterase activity and lipid peroxidation, suggesting increased acetylcholine levels and reduced oxidative stress. Histopathological examination showed improved neuronal function without toxicity. The results showed significant improvements (p < 0.001) in memory and cognitive abilities in experimental animals, highlighting the potential of ALN-βCD nanoparticles as a non-invasive treatment for memory loss. These promising findings warrant further exploration through clinical trials. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024)
►▼ Show Figures

Figure 1

21 pages, 3529 KiB  
Article
Investigation on the Combined Effect of Hydroxypropyl Beta-Cyclodextrin (HPβCD) and Polysorbate in Monoclonal Antibody Formulation
by Jiayi Huang, Shiqi Hong, Lucas Yuan Hao Goh, Hailong Zhang, Tao Peng, Keat Theng Chow, Rajeev Gokhale and Vinod Tuliani
Pharmaceuticals 2024, 17(4), 528; https://doi.org/10.3390/ph17040528 - 19 Apr 2024
Viewed by 1485
Abstract
Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE® HPβCD (hydroxypropyl beta-cyclodextrin) has functioned as a stable stabilizer for protein formulations [...] Read more.
Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE® HPβCD (hydroxypropyl beta-cyclodextrin) has functioned as a stable stabilizer for protein formulations in our previous research. The current study investigates the collaborative impact of combining polysorbates and HPβCD as excipients in protein formulations. The introduction of HPβCD in formulations showed it considerably reduced aggregation in two model proteins, bevacizumab and ipilimumab, following exposure to various stress conditions. The diffusion interaction parameter revealed a reduction in protein–protein interactions by HPβCD. In bevacizumab formulations, the subvisible particle counts per 0.4 mL of samples in commercial formulations vs. formulations containing both HPβCD and polysorbates subjected to distinct stressors were as follows: agitation, 87,308 particles vs. 15,350 particles; light, 25,492 particles vs. 6765 particles; and heat, 1775 particles vs. 460 particles. Isothermal titration calorimetry (ITC) measurement indicated a weak interaction between PS 80 and HPβCD, with a KD value of 74.7 ± 7.5 µM and binding sites of 5 × 10–3. Surface tension measurements illustrated that HPβCD enhanced the surface activity of polysorbates. The study suggests that combining these excipients can improve mAb stability in formulations, offering an alternative for the biopharmaceutical industry. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024)
►▼ Show Figures

Graphical abstract

20 pages, 4248 KiB  
Article
Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin–Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics
by Anca Hermenean, Eleftheria Dossi, Alex Hamilton, Maria Consiglia Trotta, Marina Russo, Caterina Claudia Lepre, Csilla Sajtos, Ágnes Rusznyák, Judit Váradi, Ildikó Bácskay, István Budai, Michele D’Amico and Ferenc Fenyvesi
Pharmaceuticals 2024, 17(1), 107; https://doi.org/10.3390/ph17010107 - 12 Jan 2024
Cited by 1 | Viewed by 1542
Abstract
Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase the solubility of [...] Read more.
Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase the solubility of CHR by forming a ternary complex with OTX008. The resulting increase in solubility and the mechanisms of complex formation were identified through phase-solubility studies, while dynamic light-scattering assessed the molecular associations within the CHR-OTX008-SBECD system. Nuclear magnetic resonance, differential scanning calorimetry, and computational studies elucidated the interactions at the molecular level, and cellular assays confirmed the system’s biocompatibility. Combining SBECD with OTX008 enhances CHR solubility more than using SBECD alone by forming water-soluble molecular associates in a ternary complex. This aids in the solubilization and delivery of CHR and OTX008. Structural investigations revealed non-covalent interactions essential to complex formation, which showed no cytotoxicity in hyperglycemic in vitro conditions. A new ternary complex has been formulated to deliver promising antifibrotic agents for diabetic complications, featuring OTX008 as a key structural and pharmacological component. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 601 KiB  
Review
Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications
by Stamatia Christaki, Eleni Spanidi, Eleni Panagiotidou, Sophia Athanasopoulou, Anastasia Kyriakoudi, Ioannis Mourtzinos and Konstantinos Gardikis
Pharmaceuticals 2023, 16(9), 1274; https://doi.org/10.3390/ph16091274 - 8 Sep 2023
Cited by 9 | Viewed by 2596
Abstract
Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic [...] Read more.
Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic and poorly soluble compounds. Most medicinal, food and cosmetic ingredients share the challenges of hydrophobicity and degradation that can be effectively addressed by various cyclodextrin types. Though not new or novel—their first applications appeared in the market in the 1970s—their versatility has inspired numerous developments, either on the academic or industrial level. This review article provides an overview of the ever-growing applications of cyclodextrins in the delivery of bioactive compounds from natural sources and their potential application benefits. Full article
(This article belongs to the Special Issue Cyclodextrin-Based Drug Delivery System and Its Pharmaceutical and Biomedical Application 2024)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop