Suprachoroidal Injection and Beyond: Exploring Advanced Administration Routes for Ocular Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1151

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Interests: ocular drug delivery
Special Issues, Collections and Topics in MDPI journals
Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada
Interests: ophthalmology; ophthalmic surgery; ocular pharmacology; drug delivery; ocular and retinal disease

Special Issue Information

Dear Colleagues,

I am pleased to announce that we are now welcoming submissions for a new Special Issue, entitled "Suprachoroidal Injection and Beyond: Exploring Advanced Administration Routes for Ocular Diseases".

The management and treatment of posterior segment and retinal diseases continue to pose significant challenges given the robust barriers within the ocular anatomy that limit the bioavailability and delivery of medications. Current approaches, often involving frequent dosing via eye drops or intravitreal injections, tend to exhibit significant side effects over the long term.

This Special Issue aims to explore advanced administration routes, with a spotlight on the suprachoroidal injection technique. As a novel form of targeted drug delivery to the posterior segment, it provides potential benefits such as an extended duration of action and improved bioavailability. Furthermore, the minimized risk of corticosteroid-related adverse events, such as cataracts and intraocular pressure elevation, as a result of compartmentalization, underlines the significant potential of this technique.

We are particularly interested in studies that explore the potential of suprachoroidal injection in conjunction with biotech products, and gene- and cell-based therapies. Submissions that demonstrate these combined approaches through both preclinical and clinical studies are highly encouraged. There is significant anticipation that these integrative strategies could lead to personalized treatments. We also encourage submissions that not only focus on suprachoroidal injections but also highlight other advanced routes of administration, their development, and their clinical implications. The objective is to curate a comprehensive panorama of the latest, most innovative technologies and techniques that enhance the safety and efficiency of drug delivery in the field of ophthalmology.

I am inviting you to submit your high-quality research and review articles that align with the theme of this Special Issue. We eagerly anticipate your contributions, which we believe will not only deepen the understanding of the potential of advanced administration routes, including suprachoroidal injections, but also have the potential to translate into patient-centred solutions that can greatly improve the quality of life for individuals battling posterior segment and retinal diseases.

Prof. Dr. Francisco Javier Otero-Espinar
Dr. Kevin Yang Wu
Guest Editors

Manuscript Submission Information

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Keywords

  • suprachoroidal injection
  • advanced administration routes
  • ocular diseases
  • posterior segment diseases
  • retinal diseases
  • advanced drug delivery
  • intravitreal injections
  • corticosteroid-related adverse events
  • biotech products in ophthalmology
  • gene and cell-based therapies
  • personalized treatments
  • gene-based therapy
  • cell-based therapy
  • preclinical and clinical studies
  • duration of action

Published Papers (1 paper)

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Research

16 pages, 3571 KiB  
Article
Useful Role of a New Generation of Dexamethasone, Vitamin E and Human Serum Albumin Microparticles in the Prevention of Excitotoxicity Injury in Retinal Ocular Diseases
by Javier Rodríguez Villanueva, Pedro de la Villa, Rocío Herrero-Vanrell, Irene Bravo-Osuna and Manuel Guzmán-Navarro
Pharmaceutics 2024, 16(3), 406; https://doi.org/10.3390/pharmaceutics16030406 - 15 Mar 2024
Viewed by 677
Abstract
Excitotoxicity has been linked to the pathogenesis of several serious degenerative ocular diseases. Long-term overactivation of the NMDA receptor by glutamate in retinal ganglion cells (RGCs) results in degeneration, apoptosis and loss of function leading to blindness. NMDA receptor antagonists have been proposed [...] Read more.
Excitotoxicity has been linked to the pathogenesis of several serious degenerative ocular diseases. Long-term overactivation of the NMDA receptor by glutamate in retinal ganglion cells (RGCs) results in degeneration, apoptosis and loss of function leading to blindness. NMDA receptor antagonists have been proposed as a pharmacological blockage of glutamate excitotoxicity. However, an inhibition of the pathway activated by glutamate receptors has intolerable side effects. An interesting pharmacological alternative would be the use of antiapoptotic compounds as RGCs’ neuroprotective active substances. Several mechanisms have been proposed to explain neuroprotection, including anti-inflammatory and scavenging activities. Here, the role of dexamethasone in neuroprotection was studied. For this purpose, original controlled release systems composed of microparticles containing dexamethasone with or without vitamin E and human serum albumin (HSA) were designed. The particles were prepared by the solid-in-oil-in-water (S/O/W) emulsion–evaporation technique. After properly characterization of the particles, they were intravitreally injected into an rat model of acute ocular excitotoxicity injury. The functionality of the retina was determined by electroretinography and RGCs were counted after cell immunohistochemistry. These microparticulate systems showed the ability to maintain normal electroretinal activity and promoted significant protection of RGCs. Through this proof of concept, we demonstrated that dexamethasone could be a useful anti-inflammatory agent to avoid the progression of degenerative ocular diseases. Furthermore, when administered in controlled release systems that provide low concentrations during prolonged periods of time, not only can the patient’s comfort be increased but the cytotoxicity of the drugs can also be avoided. Full article
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