Advances in the Preparation and Application of Bio-Based Hydrogels

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2224

Special Issue Editors


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Guest Editor
1. Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok 690950, Russia
2. Laboratory of Electrochemical Processes, Institute of Chemistry, FEB RAS, Vladivostok 690022, Russia
Interests: nanotechnology; material sciences; polymer sciences; colloid chemistry

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Guest Editor
Department of Chemistry, Lomonosov Moscow State University, Moscow 119991, Russia
Interests: hydrogels; implants; drugs delivery; gelation techniques

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Guest Editor
1. Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok 690922, Russia
2. A.V. Zhirmunsky National Scientific Center of Marine Biology, FEB RAS, Vladivostok 690041, Russia
Interests: merkel cell carcinoma; human polyomavirus; Avelumab; hemocytes; Crassostrea; Mytilus galloprovincialis

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Guest Editor
Institute of Macromolecular Chemistry CAS, 16200 Prague, Czech Republic
Interests: composites; structure/properties relationship

Special Issue Information

Dear Colleagues,

We live in a time of regular emergence of new diseases, including cancer as the most dangerous. In this regard, the goal of modern developments is to produce methods and tools related to personalized types of diagnosis and treatment of various diseases. Most drug delivery systems are products of chemical synthesis, which makes it possible to reduce their cost but does not guarantee a high therapeutic effect and greatly reduces their biocompatibility.

One of the optimal solutions is the creation of targeted drug delivery systems based on biopolymers. The basis is hydrogels—colloidal systems that have an amazing variety of physicochemical properties and chemical compositions. Ideal target systems include hydrogels with driven changing properties, controlled loading, and release of the active substance. In addition to the above examples, hydrogels can be used as implantable materials for severe injuries of soft tissues.

We sincerely invite you to take part in the creation of a Special Issue of the journal Polymers, dedicated to the creation and study of complex hydrogels based on molecules of biological origin. In our opinion, works devoted to the creation of various materials from nano- to large bulk systems are of contemporary interest. Hydrogels can consist of both one type of molecules and polyelectrolyte complexes and composite systems. A detailed description of the material-formation methods should be accompanied by their comprehensive study. We would like all your works to be accompanied by experiments that are as close as possible to real medical and biotechnological practices.

We will be glad to see you among the authors of the Special Issue “Advances in the Preparation and Application of Bio-Based Hydrogels”.

Dr. Vladimir Silant'ev
Prof. Dr. Irina Perminova
Dr. Vadim V. Kumeiko
Dr. Ivan Kelnar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels (nano-, micro-, bulk)
  • implants
  • drugs delivery
  • drugs storage
  • rheological systems
  • gelation techniques
  • stabilization
  • structure and mechanical properties
  • biopolymers

Published Papers (1 paper)

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Research

18 pages, 4831 KiB  
Article
Preparation and Characterization of Hydrogel Films and Nanoparticles Based on Low-Esterified Pectin for Anticancer Applications
by Aleksandra A. Patlay, Andrei S. Belousov, Vladimir E. Silant’ev, Roman A. Shatilov, Mikhail E. Shmelev, Valeri V. Kovalev, Irina V. Perminova, Ivan N. Baklanov and Vadim V. Kumeiko
Polymers 2023, 15(15), 3280; https://doi.org/10.3390/polym15153280 - 2 Aug 2023
Cited by 3 | Viewed by 1792
Abstract
Prospective adjuvant anticancer therapy development includes the establishing of drug delivery systems based on biocompatible and biodegradable carriers. We have designed films and nanoparticles (NPs) based on low-esterified pectin hydrogel using the ionic gelation method. We investigated morphology, nanomechanical properties, biocompatibility and anticancer [...] Read more.
Prospective adjuvant anticancer therapy development includes the establishing of drug delivery systems based on biocompatible and biodegradable carriers. We have designed films and nanoparticles (NPs) based on low-esterified pectin hydrogel using the ionic gelation method. We investigated morphology, nanomechanical properties, biocompatibility and anticancer activity. Hydrogel films are characterized by tunable viscoelastic properties and surface nanoarchitectonics through pectin concentration and esterification degree (DE), expressed in variable pore frequency and diameter. An in vitro study showed a significant reduction in metabolic activity and the proliferation of the U87MG human glioblastoma cell line, probably affected via the adhesion mechanism. Glioma cells formed neurosphere-like conglomerates with a small number of neurites when cultured on fully de-esterified pectin films and they did not produce neurites on the films prepared on 50% esterified pectin. Pectin NPs were examined in terms of size distribution and nanomechanical properties. The NPs’ shapes were proved spherical with a mean diameter varying in the range of 90–115 nm, and a negative zeta potential from −8.30 to −7.86 mV, which indicated their stability. The NPs did not demonstrate toxic effect on cells or metabolism inhibition, indicating good biocompatibility. Nanostructured biomaterials prepared on low-esterified pectins could be of interest for biomedical applications in adjuvant anticancer therapy and for designing drug delivery systems. Full article
(This article belongs to the Special Issue Advances in the Preparation and Application of Bio-Based Hydrogels)
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