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Polymers
Special Issues
Advancements in Pharmaceutical Polymers
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Advancements in Pharmaceutical Polymers

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2366

Special Issue Editor

Prof. Dr. Wang Dayong

E-Mail Website
Guest Editor
Laboratory of Biopharmaceuticals and Molecular Pharmacology, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
Interests: biopharmacology and molecular pharmacology

Special Issue Information

Dear Colleagues,

Both biopolymers produced by living organisms and artificial polymers have been used in pharmaceuticals. Biopolymers serve fundamental roles in organisms, including the storage of genetic information, the catalysis of biochemical reactions, signal transduction, energy storage, formation of biological structures, and mediating immunoreaction. Synthetic polymers are widely used in medicines as pharmaceutical excipients or active ingredients. The special issue's objective is to disseminate recent developments in research on pharmaceutical polymers, such as artificial polymers, nucleic acids, polypeptides, and polysaccharides, which are created with the intention of treating diseases, e.g., drug delivery across the blood-brain barrier, antibacterial peptides, transdermal administration of medicines, etc. Polymer chemistry, protein engineering, biopharmaceuticals, pharmacology, pharmaceutics, and material science are related disciplines. Review articles and research articles can both be published.

Prof. Dr. Wang Dayong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymers
  • artificial polymers

Published Papers (2 papers)

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Research

15 pages, 7942 KiB  
Article
A Molecular Integrative Study on the Inhibitory Effects of WRR and ERW on Amyloid β Peptide (1–42) Polymerization and Cell Toxicity
by Zhongyun Wu, Lianmeng Ye, Nan Yuan, Nuela Manka’a Che Ajuyo, Zhengpan Xiao, Liangwang Liu, Zuqian Chen, Yechun Pei, Yi Min and Dayong Wang
Polymers 2023, 15(22), 4356; https://doi.org/10.3390/polym15224356 - 8 Nov 2023
Viewed by 870
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease and the main pathological characteristic of AD is the deposition of Aβ42 in the brain. Inhibition of Aβ42 polymerization is one of the important research directions. Due to the pathological complexity of Alzheimer’s disease, studies on [...] Read more.
Alzheimer’s disease (AD) is a neurodegenerative disease and the main pathological characteristic of AD is the deposition of Aβ42 in the brain. Inhibition of Aβ42 polymerization is one of the important research directions. Due to the pathological complexity of Alzheimer’s disease, studies on Aβ42 polymerization inhibitors have not made significant progress worldwide. Using an independently constructed structure database of oligopeptides, in this study, molecular docking, umbrella sampling analysis of free energy, ThT fluorescence detection of Aβ42 polymerization, transmission electron microscopy, and flow cytometry detection of reactive oxygen species (ROS) and apoptosis were performed to screen tripeptides and pentapeptides that inhibit polymerization. It was found that two tripeptides, i.e., WRR and ERW, bind stably to the core of Aβ42 polymerization in the molecular dynamics analysis, and they significantly inhibited the aggregation of Aβ42 and reduced their cell toxicity in vitro. Full article
(This article belongs to the Special Issue Advancements in Pharmaceutical Polymers)
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15 pages, 4237 KiB  
Article
Effect of Molecular Weight on the Dissolution Profiles of PEG Solid Dispersions Containing Ketoprofen
by Ha Pham Le Khanh, Ádám Haimhoffer, Dániel Nemes, Liza Józsa, Gábor Vasvári, István Budai, Attila Bényei, Zoltán Ujhelyi, Pálma Fehér and Ildikó Bácskay
Polymers 2023, 15(7), 1758; https://doi.org/10.3390/polym15071758 - 31 Mar 2023
Viewed by 1840
Abstract
Solid dispersions are typically binary systems with a hydrophilic matrix polymer and a lipophilic active substance. During formulation, the drug undergoes a crystalline to amorphous phase transition, which leads to a supersaturated solution providing enhanced bioavailability. The interaction of the active substance and [...] Read more.
Solid dispersions are typically binary systems with a hydrophilic matrix polymer and a lipophilic active substance. During formulation, the drug undergoes a crystalline to amorphous phase transition, which leads to a supersaturated solution providing enhanced bioavailability. The interaction of the active substance and the polymer is unique and influences the level of supersaturation. We aimed to investigate the relationship between low molecular weight polyethylene glycol derivates PEG 1000, 1500, and 2000 and ketoprofen regarding the effect of molecular weight. The physicochemical properties of solid dispersions prepared with hot melt homogenization and their respective physical mixtures were investigated with Fourier transform infrared spectroscopy, powder X-ray diffraction and scanning electron microscopy techniques. A phase solubility study was carried out in hydrochloric acid media which showed no difference between the three polymers, but the dissolution curves differed considerably. PEG 1000 had higher percentage of released drug than PEG 1500 and 2000, which had similar results. These results indicate that when multiple low molecular weight PEGs are suitable as matrix polymers of solid dispersions, the molecular weight has only limited impact on physicochemical characteristics and interactions and further investigation is needed to select the most applicable candidate. Full article
(This article belongs to the Special Issue Advancements in Pharmaceutical Polymers)
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