Biocompatible Polymers for Tissue Engineering and Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 644

Special Issue Editor


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Guest Editor
School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, China
Interests: functional polymers; controlled drug release; stimulation-responsive polymers; nanomedicine

Special Issue Information

Dear Colleagues,

This Special Issue on “Biocompatible Polymers for Tissue Engineering and Drug Delivery” is devoted to the dissemination of high-quality original research articles or comprehensive reviews on cutting-edge developments in this interdisciplinary field. In recent years, polymer science and technology has been driven by scientific breakthroughs in biomedical applications. A large number of polymeric materials have been developed for biomedical applications, and new advances are being made for the treatment of different diseases, promoting human well-being. The increasing interest in polymeric materials may be due to their synthesis, which is often relatively low-cost and easy, as well as their potential to obtain a wide range of properties and functionalities for biomedical applications. This excitement is fostered through the convergence of physical, digital, and biological sciences, which will bring about profound changes in the way we design and produce biomedical devices, especially concerning the interfaces between polymeric and biological materials.

Dr. Xiuli Hu
Guest Editor

Manuscript Submission Information

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Keywords

  • tissue engineering
  • biomaterials
  • drug delivery
  • functional polymeric materials
  • bio-based polymeric materials
  • biodegradability of polymeric materials

Published Papers (1 paper)

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Research

13 pages, 8892 KiB  
Article
Injectable Thermo-Responsive Peptide Hydrogels and Its Enzyme Triggered Dynamic Self-Assembly
by Bowen Yin, Ruoxue Wang, Yu Guo, Liuxuan Li and Xiuli Hu
Polymers 2024, 16(9), 1221; https://doi.org/10.3390/polym16091221 - 26 Apr 2024
Viewed by 365
Abstract
Endogenous stimuli-responsive injectable hydrogels hold significant promise for practical applications due to their spatio-temporal controllable drug delivery. Herein, we report a facile strategy to construct a series of in situ formation polypeptide hydrogels with thermal responsiveness and enzyme-triggered dynamic self-assembly. The thermo-responsive hydrogels [...] Read more.
Endogenous stimuli-responsive injectable hydrogels hold significant promise for practical applications due to their spatio-temporal controllable drug delivery. Herein, we report a facile strategy to construct a series of in situ formation polypeptide hydrogels with thermal responsiveness and enzyme-triggered dynamic self-assembly. The thermo-responsive hydrogels are from the diblock random copolymer mPEG-b-P(Glu-co-Tyr). The L-glutamic acid (Glu) segments with different γ-alkyl groups, including methyl, ethyl, and n-butyl, offer specific secondary structure, facilitating the formation of hydrogel. The L-tyrosine (Tyr) residues not only provide hydrogen-bond interactions and thus adjust the sol–gel transition temperatures, but also endow polypeptide enzyme-responsive properties. The PTyr segments could be phosphorylated, and the phosphotyrosine copolymers were amphiphilies, which could readily self-assemble into spherical aggregates and transform into sheet-like structures upon dephosphorylation by alkaline phosphatase (ALP). P(MGlu-co-Tyr/P) and P(MGlu-co-Tyr) copolymers showed good compatibility with both MC3T3-E1 and Hela cells, with cell viability above 80% at concentrations up to 1000 μg/mL. The prepared injectable polypeptide hydrogel and its enzyme-triggered self-assemblies show particular potential for biomedical applications. Full article
(This article belongs to the Special Issue Biocompatible Polymers for Tissue Engineering and Drug Delivery)
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