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Polymers
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Polymers and Drug Delivery II
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Polymers and Drug Delivery II

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Chemistry".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 2688

Special Issue Editor

Prof. Dr. Stanislaw Slomkowski

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Guest Editor
Department of Engineering of Polymer Materials, Centre of Molecular and Macromolecular Studies of Polish Academy of Sciences, 90-363 Lodz, Poland
Interests: fundamental and applied studies on polymer nanoparticles; microparticles; and related materials for medical applications, in particular for medical diagnostics and drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymers play an increasingly important role in next-generation therapeutics and diagnostics. Their intrinsic properties have allowed the development of new nanomedicines that not only allow for the improved accumulation and delivery of therapeutic and diagnostic agents, but also provide routes to better understand the mechanisms of disease. Polymers have especially been exploited to improve the performance of other drug delivery systems (e.g., stealth liposomes). In view of this vast scenario of applications, researchers continue to propose new polymers characterized by improved features and biocompatibility, as well as innovative applications. Some have also been designed to successfully replace the current gold standard for stealth coatings, polyethylene glycol (PEG).

This Special Issue aims to investigate stealth polymer nano- and microparticles for drug delivery as well as polymers for medical devices with surface stealth properties. The Issue will address subjects including: synthetic polymers, natural polymers, bioconjugation of polymers, smart polymers, amphiphilic polymers, bioactive polymers, the dynamics of polymers crossing biological barriers, targeted drug delivery, polymers as drugs, etc.

Prof. Dr. Stanislaw Slomkowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • nanoparticles (NPs)
  • PEGylation
  • amphiphilic polymers
  • stealth polymers
  • smart polymers

Published Papers (2 papers)

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Research

16 pages, 5521 KiB  
Article
In Situ Synthesis of Gold Nanoparticles from Chitin Nanogels and Their Drug Release Response to Stimulation
by Jianwei Zhang, Wenjin Zhu, Jingyi Liang, Limei Li, Longhui Zheng, Xiaowen Shi, Chao Wang, Youming Dong, Cheng Li and Xiuhong Zhu
Polymers 2024, 16(3), 390; https://doi.org/10.3390/polym16030390 - 31 Jan 2024
Viewed by 636
Abstract
In this study, gold nanoparticles (AuNPs) were synthesized in situ using chitin nanogels (CNGs) as templates to prepare composites (CNGs@AuNPs) with good photothermal properties, wherein their drug release properties in response to stimulation by near-infrared (NIR) light were investigated. AuNPs with particle sizes [...] Read more.
In this study, gold nanoparticles (AuNPs) were synthesized in situ using chitin nanogels (CNGs) as templates to prepare composites (CNGs@AuNPs) with good photothermal properties, wherein their drug release properties in response to stimulation by near-infrared (NIR) light were investigated. AuNPs with particle sizes ranging from 2.5 nm to 90 nm were prepared by varying the reaction temperature and chloroauric acid concentration. The photothermal effect of different materials was probed by near-infrared light. Under 1 mg/mL of chloroauric acid at 120 °C, the prepared CNGs@AuNPs could increase the temperature by 32 °C within 10 min at a power of 2 W/cm2. The Adriamycin hydrochloride (DOX) was loaded into the CNGs@AuNPs to investigate their release behaviors under different pH values, temperatures, and near-infrared light stimulations. The results showed that CNGs@AuNPs were pH- and temperature-responsive, suggesting that low pH and high temperature could promote drug release. In addition, NIR light stimulation accelerated the drug release. Cellular experiments confirmed the synergistic effect of DOX-loaded CNGs@AuNPs on chemotherapy and photothermal therapy under NIR radiation. Full article
(This article belongs to the Special Issue Polymers and Drug Delivery II)
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18 pages, 4283 KiB  
Article
Embedded Living HER2+ Cells in a 3D Gelatin–Alginate Hydrogel as an In Vitro Model for Immunotherapy Delivery for Breast Cancer
by G. Tonantzin De Dios-Figueroa, Janette del Rocío Aguilera-Márquez, Lorena García-Uriostegui, Rodolfo Hernández-Gutiérrez, Tanya A. Camacho-Villegas and Pavel H. Lugo-Fabres
Polymers 2023, 15(18), 3726; https://doi.org/10.3390/polym15183726 - 11 Sep 2023
Viewed by 1532
Abstract
Epidermal growth factor receptor 2 (HER2) is the second target molecule most commonly used in breast cancer treatment. Both recurrence and metastasis are still deadly for HER2+ breast cancer patients. Hydrogels can be an option for developing three-dimensional (3D) cell culture systems that [...] Read more.
Epidermal growth factor receptor 2 (HER2) is the second target molecule most commonly used in breast cancer treatment. Both recurrence and metastasis are still deadly for HER2+ breast cancer patients. Hydrogels can be an option for developing three-dimensional (3D) cell culture systems that resemble tumor features better than monolayer cultures and could be used for preclinical screening for new biotherapeutics. Biopolymers (gelatin and alginate) were used to develop a hydrogel capable of encapsulating living HER2+ breast cancer cells BT-474/GFP. The hydrogel was physicochemically characterized, and the viability of embedded cells was evaluated. The hydrogel developed had suitable physical properties, with swelling of 38% of its original mass at 20 h capacity and pore sizes between 20 and 125 µm that allowed cells to maintain their morphology in a 3D environment, in addition to being biocompatible and preserving 90% of cell viability at 10 days. Furthermore, encapsulated BT-474/GFP cells maintained HER2 expression that could be detected by the Trastuzumab-fluorescent antibody, so this hydrogel could be used to evaluate new HER2-targeted therapies. Full article
(This article belongs to the Special Issue Polymers and Drug Delivery II)
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