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Polymers
Special Issues
Polymeric Drug Delivery Systems: Design, Synthesis and Applications
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Polymeric Drug Delivery Systems: Design, Synthesis and Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 3752

Special Issue Editor

Dr. Yajuan Sun

E-Mail Website
Guest Editor
1. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
2. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore
Interests: emulsion; protein; drug delivery; transdermal

Special Issue Information

Dear Colleagues,

Polymeric drug delivery systems have achieved significant development in the last few decades. However, drug delivery efficiency is still unsatisfactory, and the difficulties in regulating drug entry and accumulation at the target site with a controlled release remain. A smarter and more sustainable polymeric DDS is thus urgently needed. To address these issues, the polymeric drug delivery community is developing new polymer materials with a truly intelligent delivery system to meet the needs for specific targeting, intracellular transport, biocompatibility, and responsive behavior to physiological environments. The aim of this Special Issue is to address the recent developments in this field of research, including natural polymers, synthetic polymers, biodegradable and bio-absorbable polymers, biocompatible, biomimetic polymers, and bio-related polymers. The advanced applications of these polymeric DDSs will also be highlighted in this Special Issue. 

Dr. Yajuan Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer
  • drug delivery
  • smart
  • efficiency
  • biocompatible
  • biodegradable

Published Papers (2 papers)

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Research

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18 pages, 7853 KiB  
Article
Compound Microalgae-Type Biofunctional Hydrogel for Wound Repair during Full-Thickness Skin Injuries
by Yi Mao, Yajuan Sun and Cheng Yang
Polymers 2024, 16(5), 692; https://doi.org/10.3390/polym16050692 - 3 Mar 2024
Viewed by 812
Abstract
A dual biofunctional hydrogel (HQCS-SP) wound dressing, offering antibacterial properties and a biological response, was innovatively designed and developed to repair full-layer skin defects. The HQCS-SP hydrogel creates an artificial matrix that facilitates cell recruitment, extracellular matrix deposition, exhibiting exceptional tissue affinity, robust [...] Read more.
A dual biofunctional hydrogel (HQCS-SP) wound dressing, offering antibacterial properties and a biological response, was innovatively designed and developed to repair full-layer skin defects. The HQCS-SP hydrogel creates an artificial matrix that facilitates cell recruitment, extracellular matrix deposition, exhibiting exceptional tissue affinity, robust self-healing, effective hemostatic capabilities and accelerates wound healing. It is synthesized by crosslinking modified chitosan (HQCS) with spirulina protein (SP) and Fe3+. The HQCS provides antibacterial, antioxidant, good tissue affinity and excellent hemostasis performance. The incorporation of SP not only reinforces the antioxidant, antibacterial, anti-inflammatory, and pro-angiogenesis effects but also participates in the regulation of signal pathways and promotes wound healing. Therefore, this study offers a new visual angle for the design of advanced functional trauma dressings with great application potential in the bio-medical field. Full article
(This article belongs to the Special Issue Polymeric Drug Delivery Systems: Design, Synthesis and Applications)
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Review

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76 pages, 7024 KiB  
Review
Recent Advancements and Strategies for Overcoming the Blood–Brain Barrier Using Albumin-Based Drug Delivery Systems to Treat Brain Cancer, with a Focus on Glioblastoma
by Camelia-Elena Tincu (Iurciuc), Călin Vasile Andrițoiu, Marcel Popa and Lăcrămioara Ochiuz
Polymers 2023, 15(19), 3969; https://doi.org/10.3390/polym15193969 - 2 Oct 2023
Viewed by 2514
Abstract
Glioblastoma multiforme (GBM) is a highly aggressive malignant tumor, and the most prevalent primary malignant tumor affecting the brain and central nervous system. Recent research indicates that the genetic profile of GBM makes it resistant to drugs and radiation. However, the main obstacle [...] Read more.
Glioblastoma multiforme (GBM) is a highly aggressive malignant tumor, and the most prevalent primary malignant tumor affecting the brain and central nervous system. Recent research indicates that the genetic profile of GBM makes it resistant to drugs and radiation. However, the main obstacle in treating GBM is transporting drugs through the blood–brain barrier (BBB). Albumin is a versatile biomaterial for the synthesis of nanoparticles. The efficiency of albumin-based delivery systems is determined by their ability to improve tumor targeting and accumulation. In this review, we will discuss the prevalence of human glioblastoma and the currently adopted treatment, as well as the structure and some essential functions of the BBB, to transport drugs through this barrier. We will also mention some aspects related to the blood–tumor brain barrier (BTBB) that lead to poor treatment efficacy. The properties and structure of serum albumin were highlighted, such as its role in targeting brain tumors, as well as the progress made until now regarding the techniques for obtaining albumin nanoparticles and their functionalization, in order to overcome the BBB and treat cancer, especially human glioblastoma. The albumin drug delivery nanosystems mentioned in this paper have improved properties and can overcome the BBB to target brain tumors. Full article
(This article belongs to the Special Issue Polymeric Drug Delivery Systems: Design, Synthesis and Applications)
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