Polymers

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Prof. Dr. Yong Wang

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School of Dentistry, University of Missouri-Kansas City, Kansas City, MO 64108, USA
Interests: dental biomaterials; calcified tissue; applying new technologies in dentistry; aging and durability of polymers and biomaterials; vibrational spectroscopic characterization and spectroscopically resolved chemical imaging analysis

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Dear Colleagues,

Polymer-based materials have been used in dentistry for a long time, especially in restorative dentistry. Polymer materials can be applied in the composite filling for advanced restoration, dental implants, regenerative dentistry, and dental drug delivery. Polymers are playing major, important roles in contemporary, 3D digital dentistry and its future. Therefore, we are organizing a Special Issue on recent developments, fabrication technologies, and applications of polymer-based materials in dentistry. Researchers, scientists, and clinicians are encouraged to contribute original research papers, clinical trials or reports, reviews, and meta-analyses that will promote the continuation of polymer-based materials application in dentistry.

Prof. Dr. Yong Wang
Guest Editor

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Keywords

polymer-based materials
restorative dentistry
regenerative dentistry
polymers for 3D printing and drug delivery
dental resin and monomer synthesis
dentin collagen
composite restoration

Published Papers (1 paper)

Research

18 pages, 2999 KiB

Open AccessArticle

Effect of Different Crosslinkers on Denatured Dentin Collagen’s Biostability, MMP Inhibition and Mechanical Properties

by Saleha Nisar, Viviane Hass, Rong Wang, Mary P. Walker and Yong Wang

Polymers 2023, 15(18), 3683; https://doi.org/10.3390/polym15183683 - 7 Sep 2023

Viewed by 1224

Abstract

Objective: Sound, natural dentin collagen can be stabilized against enzymatic degradation through exogenous crosslinking treatment for durable bonding; however, the effect on denatured dentin (DD) collagen is unknown. Hence, the ability of different crosslinkers to enhance/restore the properties of DD collagen was assessed. Methods: Demineralized natural and DD collagen films (7 mm × 7 mm × 7 µm) and beams (0.8 mm × 0.8 mm × 7 mm) were prepared. DD collagen was experimentally produced by heat or acid exposure, which was then assessed by various techniques. All specimens were then treated with 1 wt% of chemical crosslinker 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/n-hydroxysuccinimide (EDC/NHS) and two structurally different flavonoids—theaflavins (TF) from black tea and type-A proanthocyanidins from cranberry juice (CR) for either 30 s or 1 h. The controls were untreated. Dentin films were assessed for chemical interaction and cross-linking effect by FTIR, biostability against exogenous collagenase by weight loss (WL) and hydroxyproline release (HYP), and endogenous matrix metalloproteinases (MMPs) activity by confocal laser microscopy. Dentin beams were evaluated for tensile properties. Data were analyzed using ANOVA and Tukey’s test (α = 0.05). Results: Compared with natural collagen, DD collagen showed pronounced structural changes, altered biostability and decreased mechanical properties, which were then improved to various degrees that were dependent on the crosslinkers used, with EDC/NHS being the least effective. Surprisingly, the well-known MMP inhibitor EDC/NHS showed negligible effect on or even increased MMP activity in DD collagen. As compared with control, cross-linking induced by TF and CR significantly increased collagen biostability (reduced WL and HYP release, p < 0.05), MMP inhibition (p < 0.001) and mechanical properties (p < 0.05), regardless of denaturation. Conclusions: DD collagen cannot or can only minimally be stabilized via EDC/NHS crosslinking; however, the challenging substrate of DD collagen can be enhanced or restored using the promising flavonoids TF and CR. Full article

(This article belongs to the Special Issue Advanced Polymer-Based Materials for Dental Applications)

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