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Hybrid Adhesive and Coatings for Medical Applications

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A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 22216

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Special Issue Editors

Prof. Dr. Hanna Dodiuk

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Guest Editor

Department of Polymer Materials Engineering, The Pernick Faculty of Engineering Shenkar College, 12 Anna Frank Street, Ramat Gan 52526, Israel
Interests: adhesives; coatings; nanotechnology; nanoparticles; biomedical polymers
Special Issues, Collections and Topics in MDPI journals

Dr. Dan Lewitus

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Guest Editor

Department of Plastics and Polymer Engineering, Shenkar Engineering, Design, Art, Ramat Gan 52526, Israel
Interests: biomaterials; polymers; adhesives; composites; drug delivery

Special Issue Information

Dear Colleagues,

The application of hybrid systems, which combine synthetic polymers with biological-sourced materials, including small molecules, proteins, ceramics, etc., has seen, in recent years, a tremendous increase in medical and biomedical applications.

This Special Issue of Polymers, titled “Hybrid Adhesive and Coatings for Medical Applications” focuses on adhesive and coating materials, which may combine synthetic polymers, synthetic and natural nanoparticles, and bio-based polymer and biomolecules. These may be pertinent in a wide range of applications, ranging from medical device coatings (such as lubricious and antithrombogenic catheter coatings), through dental adhesives and fillings, and many more.

The goal of this Special Issue is to publish original research articles and critical reviews from cutting-edge scientists, in both academia and industry, on all aspects related to the recent advances in the design, synthesis, development, application and challenges in “Hybrid Adhesive and Coatings for Medical Applications”. We intend to publish both hands-on, application-oriented papers, along with papers that explore the fundamental structure–property relationships for such hybrid systems.

Prof. Hanna Dodiuk
Dr. Dan Lewitus
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Adhesives
Coatings
Natural/Synthetic Hybrid materials
Synthetic polymers
Natural polymers
Biomolecules
Biomaterilas

Published Papers (5 papers)

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Research

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15 pages, 3053 KiB

Open AccessArticle

Hybrid Antibacterial and Electro-Conductive Coating for Textiles Based on Cationic Conjugated Polymer

by Natanel Jarach, David Meridor, Marina Buzhor, Daniel Raichman, Hanna Dodiuk, Shmuel Kenig and Elizabeth Amir

Polymers 2020, 12(7), 1517; https://doi.org/10.3390/polym12071517 - 08 Jul 2020

Cited by 11 | Viewed by 3358

Abstract

The development of efficient synthetic strategies for incorporating antibacterial coatings into textiles for pharma and medical applications is of great interest. This paper describes the preparation of functional nonwoven fabrics coated with polyaniline (PANI) via in situ polymerization of aniline in aqueous solution. The effect of three different monomer concentrations on the level of polyaniline coating on the fibers comprising the fabrics, and its electrical resistivities and antibacterial attributes, were studied. Experimental results indicated that weight gains of 0.7 and 3.0 mg/cm² of PANI were achieved. These levels of coatings led to the reduction of both volume and surface resistivities by several orders of magnitude for PANI-coated polyester-viscose fabrics, i.e., from 10⁸ to 10⁵ (Ω/cm) and from 10⁹ to 10⁵ Ω/square, respectively. Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM) confirmed the incorporation of PANI coating with an average thickness of 0.4–1.5 µm, while Thermogravimetric Analysis (TGA) demonstrated the preservation of the thermal stability of the pristine fabrics. The unique molecular structure of PANI, consisting of quaternary ammonium ions under acidic conditions, yielded an antibacterial effect in the modified fabrics. The results revealed that all types of PANI-coated fabrics totally killed S. aureus bacteria, while PANI-coated viscose fabrics also demonstrated 100% elimination of S. epidermidis bacteria. In addition, PANI-coated, PET-viscose and PET fabrics showed 2.5 log and 5.5 log reductions against S. epidermidis, respectively. Full article

(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)

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15 pages, 2645 KiB

Open AccessArticle

The Grafting of Multifunctional Antithrombogenic Chemical Networks on Polyurethane Intravascular Catheters

by Yael Roth and Dan Y. Lewitus

Polymers 2020, 12(5), 1131; https://doi.org/10.3390/polym12051131 - 15 May 2020

Cited by 7 | Viewed by 2798

Abstract

Intravascular catheters (IVCs) and other medical tubing are commonly made of polymeric materials such as polyurethane (PU). Polymers tend to be fouled by surface absorption of proteins and platelets, often resulting in the development of bacterial infections and thrombosis during catheterization, which can lead to embolism and death. Existing solutions to fouling are based on coating the IVCs with hydrophilic, anti-thrombogenic, or antimicrobial materials. However, the delamination of the coatings themselves is associated with significant morbidity, as reported by the United States Food and Drug Administration (FDA). We developed a lubricious, antimicrobial, and antithrombogenic coating complex, which can be covalently attached to the surface of industrial PU catheters. The coating complex is pre-synthesized and comprises 2-methacryloyloxyethyl phosphorylcholine (MPC) as an antifouling agent, covalently attached to branched polyethyleneimine (bPEI) as a lubricating agent. The two-step coating procedure involves PU-amine surface activation using a diisocyanate, followed by chemical grafting of the bPEI-S-MPC complex. Compared with neat PU, the coating was found to reduce the coefficient of friction of the IVC surface by 30% and the hemolysis ratio by more than 50%. Moreover, the coating exhibited a significant antimicrobial activity under JIS Z2801:2000 standard compared with neat PU. Finally, in in-vivo acute rabbit model studies, the coating exhibited significant antithrombogenic properties, reducing the thrombogenic potential to a score of 1.3 on coated surfaces compared with 3.3 on uncoated surfaces. The materials and process developed could confer lubricious, antithrombogenic, and antimicrobial properties on pre-existing PU-based catheters. Full article

(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)

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17 pages, 2805 KiB

Open AccessArticle

Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials

by Tobias Mai, Karol Wolski, Agnieszka Puciul-Malinowska, Alexey Kopyshev, Ralph Gräf, Michael Bruns, Szczepan Zapotoczny and Andreas Taubert

Polymers 2018, 10(10), 1165; https://doi.org/10.3390/polym10101165 - 18 Oct 2018

Cited by 12 | Viewed by 5795

Abstract

This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields. Full article

(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)

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Review

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30 pages, 5392 KiB

Open AccessReview

Polymers in the Medical Antiviral Front-Line

by Natanel Jarach, Hanna Dodiuk and Samuel Kenig

Polymers 2020, 12(8), 1727; https://doi.org/10.3390/polym12081727 - 31 Jul 2020

Cited by 28 | Viewed by 5326

Abstract

Antiviral polymers are part of a major campaign led by the scientific community in recent years. Facing this most demanding of campaigns, two main approaches have been undertaken by scientists. First, the classic approach involves the development of relatively small molecules having antiviral properties to serve as drugs. The other approach involves searching for polymers with antiviral properties to be used as prescription medications or viral spread prevention measures. This second approach took two distinct directions. The first, using polymers as antiviral drug-delivery systems, taking advantage of their biodegradable properties. The second, using polymers with antiviral properties for on-contact virus elimination, which will be the focus of this review. Anti-viral polymers are obtained by either the addition of small antiviral molecules (such as metal ions) to obtain ion-containing polymers with antiviral properties or the use of polymers composed of an organic backbone and electrically charged moieties like polyanions, such as carboxylate containing polymers, or polycations such as quaternary ammonium containing polymers. Other approaches include moieties hybridized by sulphates, carboxylic acids, or amines and/or combining repeating units with a similar chemical structure to common antiviral drugs. Furthermore, elevated temperatures appear to increase the anti-viral effect of ions and other functional moieties. Full article

(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)

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11 pages, 240 KiB

Open AccessEditor’s ChoiceReview

Modifications of Polymeric Membranes Used in Guided Tissue and Bone Regeneration

by Wojciech Florjanski, Sylwia Orzeszek, Anna Olchowy, Natalia Grychowska, Wlodzimierz Wieckiewicz, Andrzej Malysa, Joanna Smardz and Mieszko Wieckiewicz

Polymers 2019, 11(5), 782; https://doi.org/10.3390/polym11050782 - 02 May 2019

Cited by 41 | Viewed by 4318

Abstract

Guided tissue/bone regeneration (GTR/GBR) is a widely used procedure in contemporary dentistry. To achieve the required results of tissue regeneration, soft tissues that reproduce quickly are separated from the slow-growing bone tissue by membranes. Many types of membranes are currently in use, but none of them fulfil all of the desired features. To address this issue, further research on developing new membranes with better separation characteristics, such as membrane modification, is needed. Many of the current innovative modified materials are still in the phase of in vitro and experimental studies. A collective review on new trends in membrane modification to GTR/GBR is needed due to the widespread use of polymeric membranes and the constant development in the field of dentistry. Therefore, the aim of this review was to present an overview of polymeric membrane modifications to the GTR/GBR reported in the literature. The authors searched databases, including PubMed, SCOPUS, Web of Science, and OVID, for relevant studies that were published during 1999–2019. The following keywords were used: guided tissue regeneration, membranes, coating, and modification. A total of 17 papers were included in this review. Furthermore, the articles were divided into three groups that were based on the type of membrane modification: antibiotic coating, ion-use modifications, and others modifications, thus providing an overview of current existing knowledge in the field and encouraging further research. The results of included studies on modified barrier membranes seem to be promising, both in terms of safety and benefits for patients. However, modifications result in a large spectrum of effects. Further clinical studies are needed on a large group of patients to clearly confirm the effects that were observed in animal and in vitro studies. Full article

(This article belongs to the Special Issue Hybrid Adhesive and Coatings for Medical Applications)

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