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Polymers
Special Issues
Polymeric Biomaterials and Drug Delivery Systems II
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Polymeric Biomaterials and Drug Delivery Systems II

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 1774

Special Issue Editors

Prof. Dr. Farid Bakir

E-Mail Website
Guest Editor
Arts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, 75013 Paris, France
Interests: biopolymers; drug eluting stent; drug release mechanisms; cardiovascular diseases; kinetic models; polymer matrix; in-vitro assays
Special Issues, Collections and Topics in MDPI journals
Dr. Navideh Abbasnezhad

E-Mail Website
Guest Editor
Arts et Metiers Institute of Technology, CNAM, LIFSE, HESAM University, 75013 Paris, France
Interests: polymeric biomaterials; drug eluting stent; drug release mechanisms; cardiovascular diseases; kinetic models; polymer matrix; in-vitro assays
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric biomaterials are widely used in oral and targeted drug delivery systems, particularly in tablets and microcapsules, microparticles, microspheres, patches, balloons and drug-eluting stents, related to different pathologies. Developing and designing a drug delivery system, corresponding to a specific therapy for achieving a desired release profile, maintaining a sufficient mechanical stress, and minimizing secondary effects, is of importance. Multiple advances have been made in using polymers in these regards, both in terms of their intrinsic properties and in their processing methods.

Evaluating these conjugated carriers by considering variations in the physical and mechanical properties of polymers, and the effects of different factors such as temperature, initial drug load, circulation rate, pH, etc., are among the subjects targeted here.

This Special Issue will cover, but is not limited to, all original reviews and research articles dedicated to:

  • The potential of polymers as drug carriers, in in vitro, ex vivo or in vivo release tests;
  • Physiochemical and mechanical characterization;
  • The influence of manufacturing processes;
  • Design and optimization methods;
  • The analysis of release profiles by considering different release mechanisms;
  • Mathematical models and numerical simulation.

Prof. Dr. Farid Bakir
Dr. Navideh Abbasnezhad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric biomaterials
  • drug delivery systems
  • physical and mechanical characterizations
  • drug release mechanisms and kinetics
  • numerical and empirical modeling
  • polymer processing and manufacturing
  • biodegradability
  • biocompatibility

Published Papers (1 paper)

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Research

17 pages, 3036 KiB  
Article
Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation
by Mohammed F. Aldawsari, El-Sayed Khafagy, Hadil Faris Alotaibi and Amr Selim Abu Lila
Polymers 2022, 14(19), 4184; https://doi.org/10.3390/polym14194184 - 5 Oct 2022
Cited by 8 | Viewed by 1404
Abstract
Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF. VDF-loaded bilosomes were fabricated and optimized using a Box-Behnken design. [...] Read more.
Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF. VDF-loaded bilosomes were fabricated and optimized using a Box-Behnken design. The optimized VDF-loaded bilosomal formulation was assessed for surface morphology, particle size, thermal characteristics, and in vitro release. Afterwards, the optimized bilosomal formulation was incorporated into a cellulose-based matrix to obtain buccal sponge, which was evaluated for ex vivo permeation studies, in vivo oral bioavailability, and in vivo serum concentration of cyclic guanosine monophosphate (cGMP). The mean particle size and entrapment efficiency (%) of optimized bilosome formulation were 282.6 ± 9.5 nm and 82.95 ± 3.5%, respectively. In vitro release studies at pH 6.8 emphasized the potential of optimized bilosomal formulation to sustain VDF release for 12 h. Ex vivo permeation study using sheep buccal mucosa indicated significant enhancement in penetration of VDF from bilosomal buccal sponge compared to plain VDF gel. Pharmacokinetic study in Albino rats showed ~5 fold increase in relative bioavailability with bilosomal buccal sponge, compared to VDF suspension. In addition, VDF-loaded bilosomal buccal sponge triggered higher serum levels of cGMP, a biomarker of VDF in vivo efficacy, compared to oral VDF suspension. To sum up, bilosomes might represent a potential nanocarrier for buccal delivery of VDF, enhancing its oral bioavailability and therapeutic efficacy. Full article
(This article belongs to the Special Issue Polymeric Biomaterials and Drug Delivery Systems II)
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