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Processes
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MicroRNA Mechanism
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MicroRNA Mechanism

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 5394

Special Issue Editor

Prof. Dr. Hsiuying Wang

E-Mail Website
Guest Editor
Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan
Interests: anti-NMDA receptor encephalitis; microRNA; molecular biomarkers; phylogenetic analysis; bioinformatics; industry statistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNA) are small non-coding RNA playing an important role in many biology processes including cell differentiation, development, cell cycle regulation, cell proliferation, and apoptosis. miRNAs also induce or promote cancer cell apoptosis by epigenetic mechanisms and are involved in the development of drug resistance. miRNAs can be detected in body fluids and tissues. Circulating miRNAs are useful diagnosis and prognosis biomarkers for many diseases. In addition, miRNAs can be used to explore the association between different diseases. Various studies have described their mechanisms of actions, cellular pathways, and regulation as well as their role as disease biomarkers through in vitro and in vivo experiments and using bioinformatics analysis. Nevertheless, many new miRNAs are being discovered, and their function is not yet well characterized.

This Special Issue on “MicroRNA Mechanisms” seeks high-quality reviews and original research papers focusing on a wide range of miRNA aspects, including miRNA signaling pathways, miRNA therapeutics, miRNA regulation. Topics of interest include, but are not limited to:

  • miRNA biogenesis
  • miRNA biomarkers
  • miRNA epigenetics
  • miRNA evolutionary processes
  • miRNA networks
  • miRNA pathways
  • miRNA regulation
  • miRNA therapeutics 

Prof. Dr. Hsiuying Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • apoptosis
  • biogenesis
  • biomarker
  • disease, epigenetics
  • microRNA
  • network
  • pathway
  • proliferation

Published Papers (2 papers)

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Review

18 pages, 619 KiB  
Review
Expression of Selected microRNAs in Migraine: A New Class of Possible Biomarkers of Disease?
by Lara Ahmad, Chiara Demartini, Michele Corrado, Gloria Vaghi, Elisa Maria Piella, Marta Allena, Anna Maria Zanaboni, Rosaria Greco, Cristina Tassorelli and Roberto De Icco
Processes 2021, 9(12), 2199; https://doi.org/10.3390/pr9122199 - 06 Dec 2021
Cited by 5 | Viewed by 2855
Abstract
Preliminary but convergent findings suggest a role for microRNAs (miRNAs) in the generation and maintenance of chronic pain and migraine. Initial observations showed that serum levels of miR-382-5p and miR-34a-5p expression were increased in serum during the migraine attack, with miR-382-5p increasing in [...] Read more.
Preliminary but convergent findings suggest a role for microRNAs (miRNAs) in the generation and maintenance of chronic pain and migraine. Initial observations showed that serum levels of miR-382-5p and miR-34a-5p expression were increased in serum during the migraine attack, with miR-382-5p increasing in the interictal phase as well. By contrast, miR-30a-5p levels were lower in migraine patients compared to healthy controls. Of note, antimigraine treatments proved to be capable of influencing the expression of these miRNAs. Altogether, these observations suggest that miRNAs may represent migraine biomarkers, but several points are yet to be elucidated. A major concern is that these miRNAs are altered in a broad spectrum of painful and non-painful conditions, and thus it is not possible to consider them as truly “migraine-specific” biomarkers. We feel that these miRNAs may represent useful tools to uncover and define different phenotypes across the migraine spectrum with different treatment susceptibilities and clinical features, although further studies are needed to confirm our hypothesis. In this narrative review we provide an update and a critical analysis of available data on miRNAs and migraines in order to propose possible interpretations. Our main objective is to stimulate research in an area that holds promise when it comes to providing reliable biomarkers for theoretical and practical scientific advances. Full article
(This article belongs to the Special Issue MicroRNA Mechanism)
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19 pages, 1354 KiB  
Review
MicroRNA as a Biomarker for Diagnostic, Prognostic, and Therapeutic Purpose in Urinary Tract Cancer
by Amro M. Soliman, Mohamed Soliman, Srijit Das and Seong Lin Teoh
Processes 2021, 9(12), 2136; https://doi.org/10.3390/pr9122136 - 26 Nov 2021
Viewed by 1510
Abstract
The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression [...] Read more.
The incidence of urologic cancers, including kidney, upper tract urothelial, and bladder malignancies, is increasing globally, with a high percentage of cases showing metastasis upon diagnosis and low five-year survival rates. MicroRNA (miRNA), a small non-coding RNA, was found to regulate the expression of oncogenes and tumor suppressor genes in several tumors, including cancers of the urinary system. In the current review, we comprehensively discuss the recently reported up-or down-regulated miRNAs as well as their possible targets and regulated pathways involved in the development, progression, and metastasis of urinary tract cancers. These miRNAs represent potential therapeutic targets and diagnostic/prognostic biomarkers that may help in efficient and early diagnosis in addition to better treatment outcomes. Full article
(This article belongs to the Special Issue MicroRNA Mechanism)
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