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Biosensors Incorporating Nano-particles
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Biosensors Incorporating Nano-particles

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 25065

Special Issue Editor

Dr. Ashutosh Tiwari

E-Mail Website
Guest Editor
College of Engineering, Department of Materials Science and Engineering, University of Utah, Salt Lake City, UT 84112, USA
Interests: nanostructured materials; biosensors; electronic materials; magnetic materials; thin films; spintronics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanotechnology is playing an increasingly important role in the development of biosensors. Various kinds of nanomaterials, such as gold nanoparticles, carbon nanotubes (CNTs), magnetic nanoparticles and quantum dots, are being gradually applied to biosensors because of their unique physical, chemical, mechanical, magnetic and optical properties, and markedly enhance the sensitivity and specificity of detection. The nano-biosensors have been widely used in the fields of in vitro diagnostics, imaging, cell tracking and labeling, delivery of drugs and biomolecules.

There have been numerous publications on various aspects of nanobiosensors since the 1970s. The aim of this special issue is to report the current state-of-the-art progress in Nano-Biosensing research and technology. We welcome submissions from any area of biosensors incorporating nano-particles, including fabrication, design and functioning of nano-biosensors using various materials and techniques. Both reviews and original research articles are encouraged.

Dr. Ashutosh Tiwari

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biosensors
  • Nanoparticles
  • Microfluidic
  • Carbon nanotubes
  • Quantum dots
  • Surface plasmon resonance (LSPR) sensor
  • Optical Nanobiosensors
  • Glucose Biosensors
  • Magnetic Biosensors
  • Nanowire Biosensors

Published Papers (7 papers)

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Research

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11 pages, 3180 KiB  
Communication
Size of Heparin-Imprinted Nanoparticles Reflects the Matched Interactions with the Target Molecule
by Yasuo Yoshimi, Daichi Oino, Hirofumi Ohira, Hitoshi Muguruma, Ewa Moczko and Sergey A. Piletsky
Sensors 2019, 19(10), 2415; https://doi.org/10.3390/s19102415 - 27 May 2019
Cited by 14 | Viewed by 3523
Abstract
It has been shown that the faradic current at an electrode grafted with molecularly imprinted polymer (MIP) is sensitive to the specific target molecule used as the template. This phenomenon is applicable to sensors with very high selectivity, but the sensing mechanism is [...] Read more.
It has been shown that the faradic current at an electrode grafted with molecularly imprinted polymer (MIP) is sensitive to the specific target molecule used as the template. This phenomenon is applicable to sensors with very high selectivity, but the sensing mechanism is still a black box. We investigated the size sensitivity of nanoparticles of molecularly imprinted polymers (MIP-NPs) to a specific interaction for determination of the mechanism of the gate effect and its feasibility for new applications. Nanoparticles of poly(methacryloxy ethyl trimethylammonium chloride-co-acrylamide-co-methylenebisacrylamide) imprinted with heparin immobilized on glass beads were synthesized. The diameter of the MIP-NPs of heparin was increased by the presence of the heparin template but was insensitive to chondroitin sulfate C (CSC), the analogue of heparin. The high selectivity of the MIP-NPs was consistent with the selectivity of electrodes grafted with a heparin-imprinted polymer in our previous studies. The quartz crystal microbalance probes immobilizing heparin or CSC were sensitive to MIP-NPs, which indicates that the binding ability of MIP-NP does not discriminate between the template and other glycosaminoglycans. These results indicate that the size of the MIP-NP is sensitive to the matched binding with the template through the imprinted cavity. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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14 pages, 5705 KiB  
Article
Potential Application of h-BNC Structures in SERS and SEHRS Spectroscopies: A Theoretical Perspective
by Sara Gil-Guerrero, Nicolás Otero, Marta Queizán and Marcos Mandado Alonso
Sensors 2019, 19(8), 1896; https://doi.org/10.3390/s19081896 - 21 Apr 2019
Cited by 5 | Viewed by 3248
Abstract
In this work, the electronic and optical properties of hybrid boron-nitrogen-carbon structures (h-BNCs) with embedded graphene nanodisks are investigated. Their molecular affinity is explored using pyridine as model system and comparing the results with the corresponding isolated graphene nanodisks. Time-dependent density functional theory [...] Read more.
In this work, the electronic and optical properties of hybrid boron-nitrogen-carbon structures (h-BNCs) with embedded graphene nanodisks are investigated. Their molecular affinity is explored using pyridine as model system and comparing the results with the corresponding isolated graphene nanodisks. Time-dependent density functional theory (TDDFT) analysis of the electronic excited states was performed in the complexes in order to characterize possible surface and charge transfer resonances in the UV region. Static and dynamic (hyper)polarizabilities were calculated with coupled-perturbed Kohn-Sham theory (CPKS) and the linear and nonlinear optical responses of the complexes were analyzed in detail using laser excitation wavelengths available for (Hyper)Raman experiments and near-to-resonance excitation wavelengths. Enhancement factors around 103 and 108 were found for the polarizability and first order hyperpolarizability, respectively. The quantum chemical simulations performed in this work point out that nanographenes embedded within hybrid h-BNC structures may serve as good platforms for enhancing the (Hyper)Raman activity of organic molecules immobilized on their surfaces and for being employed as substrates in surface enhanced (Hyper)Raman scattering (SERS and SEHRS). Besides the better selectivity and improved signal-to-noise ratio of pristine graphene with respect to metallic surfaces, the confinement of the optical response in these hybrid h-BNC systems leads to strong localized surface resonances in the UV region. Matching these resonances with laser excitation wavelengths would solve the problem of the small enhancement factors reported in Raman experiments using pristine graphene. This may be achieved by tuning the size/shape of the embedded nanographene structure. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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13 pages, 2154 KiB  
Article
Electrochemical Enzyme Biosensor Bearing Biochar Nanoparticle as Signal Enhancer for Bisphenol A Detection in Water
by Yang Liu, Lan Yao, Lingzhi He, Na Liu and Yunxian Piao
Sensors 2019, 19(7), 1619; https://doi.org/10.3390/s19071619 - 04 Apr 2019
Cited by 44 | Viewed by 4795
Abstract
An electrochemical tyrosinase enzyme (Tyr) biosensor using a highly conductive sugarcane derived biochar nanoparticle (BCNP) as a transducer and signal enhancer (BCNPs/Tyr/Nafion/GCE) was developed for the sensitive detection of bisphenol A (BPA). The BCNPs/Tyr/Nafion/GCE biosensor exhibited improved amperometric current responses such as higher [...] Read more.
An electrochemical tyrosinase enzyme (Tyr) biosensor using a highly conductive sugarcane derived biochar nanoparticle (BCNP) as a transducer and signal enhancer (BCNPs/Tyr/Nafion/GCE) was developed for the sensitive detection of bisphenol A (BPA). The BCNPs/Tyr/Nafion/GCE biosensor exhibited improved amperometric current responses such as higher sensing signal, decreased impedance and lowered reduction potential compared with the Tyr/Nafion/GCE due to high conductivity property of the biochar nanoparticle. Under the optimized conditions, it could detect BPA in good sensitivity with linear range from 0.02 to 10 μM, and a lowest detection limit of 3.18 nM. Moreover, it showed a low Km value, high reproducibility and good selectivity over other reagents, and the BCNPs/Tyr complex solution also showed good stability with 86.9% of sensing signal maintained after one month storage. The biosensor was also successfully utilized for real water detection with high accuracy as validated by high performance liquid chromatography. Therefore, the biochar nanoparticle based enzyme biosensor proved to be a potential and reliable method for high performance detection of pollutants in the environment. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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10 pages, 3274 KiB  
Article
Ag@Au Core–Shell Porous Nanocages with Outstanding SERS Activity for Highly Sensitive SERS Immunoassay
by Yaqi Huang, Dajie Lin, Mengting Li, Dewu Yin, Shun Wang and Jichang Wang
Sensors 2019, 19(7), 1554; https://doi.org/10.3390/s19071554 - 31 Mar 2019
Cited by 15 | Viewed by 4437
Abstract
A highly sensitive immunoassay of biomarkers has been achieved using 4-mercaptobenzoic acid-labeled Ag@Au core–shell porous nanocage tags and α-fetoprotein immuno-sensing chips. The Ag@Au porous nanocages were uniquely synthesized by using an Ag core as a self-sacrificial template and reducing agent, where the slow [...] Read more.
A highly sensitive immunoassay of biomarkers has been achieved using 4-mercaptobenzoic acid-labeled Ag@Au core–shell porous nanocage tags and α-fetoprotein immuno-sensing chips. The Ag@Au porous nanocages were uniquely synthesized by using an Ag core as a self-sacrificial template and reducing agent, where the slow reaction process led to the formation of a porous Au layer. The size of the remaining Ag core and surface roughness of the Au shell were controlled by adjusting the chloroauric acid concentration. The porous cage exhibited excellent surface-enhanced Raman spectroscopy (SERS) activity, presumably due to a synergetic interaction between newly generated hot spots in the rough Au shell and the retained SERS activity of the Ag core. Using α-fetoprotein as a model analyte for immunoassay, the SERS signal had a wide linear range of 0.20 ng mL−1 to 500.0 ng mL−1 with a detection limit of 0.12 ng mL−1. Without the need of further signal amplification, the as-prepared Ag@Au bimetallic nanocages can be directly used for highly sensitive SERS assays of other biomarkers in biomedical research, diagnostics, etc. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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18 pages, 3904 KiB  
Article
Ionic Liquid-Polypyrrole-Gold Composites as Enhanced Enzyme Immobilization Platforms for Hydrogen Peroxide Sensing
by Meng Li, Jing Wu, Haiping Su, Yan Tu, Yazhuo Shang, Yifan He and Honglai Liu
Sensors 2019, 19(3), 640; https://doi.org/10.3390/s19030640 - 03 Feb 2019
Cited by 14 | Viewed by 3417
Abstract
In this work, three different aqueous solutions containing imidazole-based ILs with different alkyl chain lengths ([Cnmim]Br, n = 2, 6, 12) were adopted as the medium for the synthesis of ionic liquid-polypyrrole (IL-PPy) composites. Herein, the ILs undertook the roles of [...] Read more.
In this work, three different aqueous solutions containing imidazole-based ILs with different alkyl chain lengths ([Cnmim]Br, n = 2, 6, 12) were adopted as the medium for the synthesis of ionic liquid-polypyrrole (IL-PPy) composites. Herein, the ILs undertook the roles of the pyrrole solvent, the media for emulsion polymerization of PPy and PPy dopants, respectively. The electrochemical performances of the three IL-PPy composites on a glassy carbon electrode (GCE) were investigated by electrochemical experiments, which indicated that [C12mim]Br-PPy (C12-PPy) composites displayed better electrochemical performance due to their larger surface area and firmer immobilization on the GCE. Further, C12-PPy/GCE were decorated with Au microparticles by electrodeposition that can not only increase the conductivity, but also immobilize sufficient biomolecules on the electrode. Then, the obtained C12-PPy-Au/GCE with outstanding electrochemical performance was employed as a horseradish peroxidase (HRP) immobilization platform to fabricate a novel C12-PPy-Au-HRP/GCE biosensor for H2O2 detection. The results showed that the prepared C12-PPy-Au-HRP/GCE biosensor exhibited high sensitivity, fast response, and a wide detection range as well as low detection limit towards H2O2. This work not only provides an outstanding biomolecule immobilization matrix for the fabrication of highly sensitive biosensors, but also advances the understanding of the roles of ILs in improving the electrochemical performance of biosensors. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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12 pages, 3468 KiB  
Article
A NiFe Alloy Reduced on Graphene Oxide for Electrochemical Nonenzymatic Glucose Sensing
by Zhe-Peng Deng, Yu Sun, Yong-Cheng Wang and Jian-De Gao
Sensors 2018, 18(11), 3972; https://doi.org/10.3390/s18113972 - 15 Nov 2018
Cited by 19 | Viewed by 3401
Abstract
A NiFe alloy nanoparticle/graphene oxide hybrid (NiFe/GO) was prepared for electrochemical glucose sensing. The as-prepared NiFe/GO hybrid was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The results indicated that NiFe alloy nanoparticles can be successfully deposited on GO. The electrochemical [...] Read more.
A NiFe alloy nanoparticle/graphene oxide hybrid (NiFe/GO) was prepared for electrochemical glucose sensing. The as-prepared NiFe/GO hybrid was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The results indicated that NiFe alloy nanoparticles can be successfully deposited on GO. The electrochemical glucose sensing performance of the as-prepared NiFe/GO hybrid was studied by cyclic voltammetry and amperometric measurement. Results showed that the NiFe/GO-modified glassy carbon electrode had sensitivity of 173 μA mM−1 cm−2 for glucose sensing with a linear range up to 5 mM, which is superior to that of commonly used Ni nanoparticles. Furthermore, high selectivity for glucose detection could be achieved by the NiFe/GO hybrid. All the results demonstrated that the NiFe/GO hybrid has promise for application in electrochemical glucose sensing. Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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1 pages, 159 KiB  
Erratum
Erratum: Yoshimi, Y., et al. Size of Heparin-Imprinted Nanoparticles Reflects the Matched Interactions with the Target Molecule. Sensors 2019, 19, 2415
by Yasuo Yoshimi, Daichi Oino, Hirofumi Ohira, Hitoshi Muguruma, Ewa Moczko and Sergey A. Piletsky
Sensors 2019, 19(17), 3646; https://doi.org/10.3390/s19173646 - 21 Aug 2019
Cited by 3 | Viewed by 1775
Abstract
The authors wish to make the following erratum to this paper [...] Full article
(This article belongs to the Special Issue Biosensors Incorporating Nano-particles)
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