Novel Sample Preparation Approaches for the Determination of Drugs Using Separation Techniques

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2054

Special Issue Editors


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Guest Editor
Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: analytical chemistry; sample preparation; HPLC; extraction techniques; microextraction; green analytical chemistry; method validation; method development; GC; GC-MS; volatiles; SPME; metals; nutrients; toxic metals; rare earths; automation; ICP-AES; ICP-MS
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Guest Editor
Laboratory of Pharmaceutical Analysis, Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: pharmaceutical analytical chemistry; method development and validation; sample preparation (derivatization, microextraction, etc.); liquid and gas chromatography; capillary electrophoresis; mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The determination of drugs and their residues in biological, food and environmental samples comprise a challenging analytical task due to the low concentration of the target analytes and the simultaneous presence of potentially interfering compounds. In recent years, a plethora of novel microextraction and miniaturized extraction techniques, which comply with the principles of Green Analytical Chemistry and Green Sample Preparation have been developed. Typical examples of these techniques include sorbent-based approaches such as solid-phase microextraction (SPME), stir bar sorptive extraction (SBSE), pipette-tip solid-phase extraction (PT-SPE), dispersive solid-phase extraction (d-SPE), magnetic solid-phase extraction (MSPE), fabric phase sorptive extraction (FPSE) and capsule phase microextraction (CPME), as well as liquid based-approaches such as dispersive liquid-liquid microextraction (DLLME), thin-film liquid-phase microextraction (TF-LPME) and homogeneous liquid-liquid microextraction (HLLME). These techniques serve as powerful analytical tools for the monitoring of drug molecules.

At the same time, various novel smart materials including molecularly imprinted polymers (MIPs), metal–organic frameworks (MOFs), covalent organic frameworks (COFs), graphene oxide (GO), carbon nanotubes (CNTs), ionic liquids (ILs) and deep eutuctic solvents (DESs) have been proposed for the selective and efficient extraction of drug molecules.

This Special Issue welcomes original research articles and reviews reporting the developments and applications of novel sample preparation techniques for the determination of drugs in various matrices (biological, pharmaceutical, food, environmental, etc.).

Please note that in the cases of review articles an additional brief (1-2 pages) description of the topic including a draft index is required. This preliminary step is essential to avoid overlapping topics.

Dr. Natalia Manousi
Dr. Constantinos K. Zacharis
Guest Editors

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Keywords

  • pharmaceutical analysis
  • drug analysis
  • bioanalytical methods
  • drug residues
  • food analysis
  • environmental analysis
  • sample preparation
  • novel materials
  • microextraction
  • green analytical chemistry

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Published Papers (1 paper)

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Research

11 pages, 989 KiB  
Article
Magnet Integrated Fabric Phase Sorptive Extraction for the Extraction of Resin Monomers from Human Urine Prior to HPLC Analysis
by Georgios Antoniou, Vasileios Alampanos, Abuzar Kabir, Torki Zughaibi, Kenneth G. Furton and Victoria Samanidou
Separations 2023, 10(4), 235; https://doi.org/10.3390/separations10040235 - 3 Apr 2023
Cited by 1 | Viewed by 1492
Abstract
In this work, a method for the simultaneous determination of four resin monomers: Bisphenol A, bisphenol A methacrylate glycidate, triethyleneglycol-dimethacrylate, and urethane dimethacrylate, from human urine using magnet integrated fabric phase sorptive extraction (MI-FPSE), followed by high performance liquid chromatography (HPLC) diode array [...] Read more.
In this work, a method for the simultaneous determination of four resin monomers: Bisphenol A, bisphenol A methacrylate glycidate, triethyleneglycol-dimethacrylate, and urethane dimethacrylate, from human urine using magnet integrated fabric phase sorptive extraction (MI-FPSE), followed by high performance liquid chromatography (HPLC) diode array detection (HPLC-DAD), is presented. MI-FPSE is a novel configuration of FPSE that incorporates the stirring and extraction mechanism into one device, resulting in an improved extraction kinetic factor. FPSE is a green sample preparation technique that uses a flexible surface, such as cellulose, coated with a polymeric material using sol–gel technology. Poly(tetrahydrofuran) (PTHF) material was selected, due to its higher efficiency in terms of recovery rate among the studied MI-FPSE membranes. Optimization of the extraction process was performed based on several extraction and elution parameters. The method was validated for its linearity, selectivity, accuracy, precision, and stability of the samples. For the four compounds, the LOD and LOQ were 0.170 ng/μL and 0.050 ng/μL, respectively. The relative standard deviation of the method was less than 9.8% and 11.9%, for the within-day and between-day precision, respectively. The relative recoveries were between 85.6 and 105.2% in all cases, showing a good accuracy. The effectiveness of the proposed method was confirmed through successful application to the bioanalysis of real urine samples. Full article
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