The Botulinum Toxin and Spasticity: Exploring New Horizons

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 908

Special Issue Editors


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Guest Editor
Physical Medicine and Rehabilitation, Spasticity and Movement Disorder Unit, Policlinico Riuniti, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy
Interests: spasticity; botulinum neurotoxin; neurological rehabilitation; robotics for neurological rehabilitation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Physical Medicine and Rehabilitation Section, Villa Beretta Rehabilitation Center, Via N. Sauro 17, 23845 Costa Masnaga, Italy
Interests: pharmacological treatments for spasticity and movement disorders; robotic technologies for neuroplasticity and recovery; brain and spinal cord injuries

Special Issue Information

Dear Colleagues,

It is with great enthusiasm that we, Prof. Andrea Santamato and Dr. Franco Molteni, invite you to contribute to a pivotal Special Issue of the Toxins journal, entitled "The Botulinum Toxin and Spasticity: Exploring New Horizons". Our shared expertise and commitment to the study and treatment of spasticity have motivated us to bring together this comprehensive collection of studies.

In the dynamic field of neurorehabilitation, the application of the botulinum toxin has emerged as a transformative approach to managing spasticity. This Special Issue is dedicated to unraveling the intricate mechanisms and expanding the clinical applications of the botulinum toxin, thereby improving therapeutic outcomes for patients.

We welcome submissions that delve into the latest research, innovative treatments, and comprehensive reviews on this topic. Areas of particular interest include but are not limited to:

  • Tailoring the botulinum toxin for spasticity due to conditions such as stroke, cerebral palsy, multiple sclerosis, and spinal cord injuries.
  • Highlighting advancements in neurophysiological studies and other tools for improving treatments and understanding patient outcomes.
  • Integrating the botulinum toxin with neurostimulation, physical modalities, robotic strategies and other advanced technologies for a multimodal and holistic patient care approach.
  • Discussing innovative approaches, existing challenges, and future directions in the therapeutic application of the botulinum toxin.
  • Investigating the role of artificial intelligence and machine learning in optimizing the clinical management of spasticity, including diagnostic tools, treatment planning, and outcome prediction.
  • Focusing on the long-term effects and quality of life for patients undergoing botulinum toxin therapy.

Our ambition with this Special Issue is to create a platform that not only consolidates our current knowledge, but also ignites innovative discussions and collaborations in the field of spasticity treatment.

We eagerly anticipate your submissions of original research papers and comprehensive reviews. Your expertise will significantly contribute to advancing our collective understanding of the botulinum toxin in the nuanced management of spasticity and its applications.

Warm regards,

Prof. Dr. Andrea Santamato
Dr. Franco Molteni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • botulinum toxin
  • spasticity treatment
  • neurorehabilitation

Published Papers (1 paper)

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Review

42 pages, 34187 KiB  
Review
The Role of Botulinum Toxin Type-A in Spasticity: Research Trends from a Bibliometric Analysis
by Salvatore Facciorusso, Stefania Spina, Alessandro Picelli, Alessio Baricich, Gerard E. Francisco, Franco Molteni, Jörg Wissel and Andrea Santamato
Toxins 2024, 16(4), 184; https://doi.org/10.3390/toxins16040184 - 09 Apr 2024
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Abstract
Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. [...] Read more.
Botulinum toxin type-A (BoNT-A) has emerged as a key therapeutic agent for the management of spasticity. This paper presents a comprehensive bibliometric and visual analysis of research concerning BoNT-A treatment of spasticity to elucidate current trends and future directions in this research area. A search was conducted in the Web of Science database for articles focused on the use of BoNT-A in spasticity published between 2000 and 2022. We extracted various metrics, including counts of publications and contributions from different countries, institutions, authors, and journals. Analytical methods in CiteSpace were employed for the examination of co-citations, collaborations, and the co-occurrence of keywords. Our search yielded 1489 publications. Analysis revealed a consistent annual increase in research output. The United States, United Kingdom, and Italy were the leading contributors. The top institution in this research was Assistance Publique Hopitaux, Paris. The journal containing the highest number of relevant publications was Toxins. Key frequently occurring keywords were ‘stroke’, ‘cerebral palsy’, ‘adult spasticity’, and ‘upper extremity’. This study identified 12 clusters of keywords and 15 clusters of co-cited references, indicating the main focus areas and emerging themes in this field. This study comprehensively analyzed and summarized trends in BoNT-A research in the field of spasticity over the past 22 years. Full article
(This article belongs to the Special Issue The Botulinum Toxin and Spasticity: Exploring New Horizons)
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