Contribution of Uremic Toxins to Chronic Kidney Disease Progression

Dear Colleagues, 

Chronic kidney disease (CKD) progression remains an ongoing concern worldwide, even in the era of optimized blood pressure, reduced albuminuria and improved diabetes control in the human population. Despite the introduction of ACE inhibitors, aldosterone blockers and most recently SGLT-2 inhibitors, kidney disease progression remains the rule rather than the exception in the majority of CKD patients. The ultimate goal for nephrologists is to achieve a sufficient delay in disease progression so that patients’ overall life expectancy is exceeded by the functional survival of residual renal parenchyma, to afford a life span without kidney replacement therapy needed. The presence of decreased glomerular filtration rate (GFR), especially with suboptimal blood pressure control and albuminuria, represents the largest risk factor for further ongoing loss of renal function, in the context of the accumulation of uremic toxins and an imbalanced metabolic environment. Sedentary lifestyle, excess body weight and suboptimal diet, along with the stress of environmental heat exposure with climate change, represent additional stressors in those with reduced functional renal parenchyma. In our Special Issue, we are aiming to review new and emerging concepts with regard to the accumulation of specific uremic toxins contributing to the progression of the decline in renal function. We hope that these papers will provide further impetus for research to explore novel approaches of interventions.

As the Guest Editor of this Special Issue I invite you to submit relevant papers for consideration with rigorous peer review and expeditious publication. We particularly welcome papers bringing forth novel concepts or challenging prevailing concepts and clinical inertia. All original investigations, including both clinical and basic sciences studies, as well meta-analyses and scholarly review papers will be considered. 

Prof. Dr. Tibor Fülöp
Dr. Mihály Tapolyai
Dr. Lajos Zsom
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• acidosis
• meta-analysis
• progression
• uremic toxins
• volume overload