Human Leukocyte Antigen (HLA) and Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Therapeutic Vaccines and Antibody Therapeutics".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 5557

Special Issue Editors


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Guest Editor
Department of Neuroscience, Brain Sciences Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: human leukocyte antigen; vaccines against pathogens; vaccines against SARS-CoV-2; vaccines against cancer; human herpes and other viruses; cancer neoantigens
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Guest Editor
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: cell biology and biochemistry; vaccines; gulf war illness; neurodegenerative diseases

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Guest Editor
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: Aging; Dementia; Human Leukocyte Antigen; PTSD; resilience

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Guest Editor
Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: Bioinformatics; Vaccines; Human Leukocyte Antigen; Immunogenetics; Computational Biology

Special Issue Information

Dear Colleagues,

The success of vaccines in preventing illness depends on our ability to make antibodies against the pathogen components contained in the vaccines; if antibodies cannot be made, the vaccine will not be effective. In this case, vaccine antigens persist with the possibility of causing cell damage either directly or via molecular mimicry and autoimmunity. Now, the mounting of antibodies against specific antigens critically depends on the individual's Human Leukocyte Antigen (HLA) Class 2 genetic makeup, which consists of more than six alleles (two for each of the DRB1, DQB1, and DPB1 genes, plus the occasional DRB3, DRB4, and DRB5 allele). This Special Issue will focus on this matter, which is of major medical and public health importance but hardly covered elsewhere.

Prof. Apostolos P. Georgopoulos
Dr. Effie-Photini Tsilibary
Dr. Lisa M. James
Dr. Spyros Charonis
Guest Editors

Manuscript Submission Information

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Keywords

  • vaccines
  • persistent antigens
  • human leukocyte antigen
  • brain
  • neural cultures
  • antibodies

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Published Papers (1 paper)

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Research

13 pages, 2636 KiB  
Article
Yeast-Based Aβ1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice
by Dong-qun Liu, Shuai Lu, Lun Zhang, Ya-ru Huang, Mei Ji, Xiao-ying Sun, Xiao-ge Liu and Rui-tian Liu
Vaccines 2020, 8(3), 351; https://doi.org/10.3390/vaccines8030351 - 1 Jul 2020
Cited by 10 | Viewed by 4190
Abstract
Immunotherapy focusing on reducing the amyloid-beta (Aβ) burden is a promising treatment strategy for Alzheimer’s disease (AD). Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer [...] Read more.
Immunotherapy focusing on reducing the amyloid-beta (Aβ) burden is a promising treatment strategy for Alzheimer’s disease (AD). Many clinical studies on AD immunotherapies have failed due to low safety and efficacy, calling for a highly potent AD vaccine which induces sufficient antibody titer while avoiding side effects. Here, we designed a yeast-based vaccine Y-5A15 comprising five copies of Aβ1-15 displayed on the surface of yeast cell wall, and we subcutaneously immunized APP/PS1 mice three times. Our results demonstrated that the Y-5A15 remarkably enhanced the Aβ epitope immunogenicity and elicited high antibody titers against Aβ in AD mice. Importantly, Y-5A15 vaccination successfully reduced Aβ levels, plaque burden and glial activation, rescued synaptic deficits and significantly ameliorated memory and cognitive decline in APP/PS1 transgenic mice, suggesting that the yeast-based Aβ epitope vaccine has a promising potency for the treatment of AD. Full article
(This article belongs to the Special Issue Human Leukocyte Antigen (HLA) and Vaccines)
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