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Veterinary Sciences
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Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future...
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Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future Directions

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Biomedical Sciences".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 11652

Special Issue Editors

Dr. Hussein M. El-Husseiny

E-Mail Website
Guest Editor
1. Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology (TUAT), Fuchu, Tokyo 183-0054, Japan
2. Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt
Interests: regenerative therapy; stem cells; materials and biomaterials for biomedical applications; tissue bioengineering; cardiology; echocardiography; veterinary surgery; anaesthesiology; radiology
Prof. Dr. Ryou Tanaka

E-Mail Website
Guest Editor
Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo 183-0054, Japan
Interests: cardiothoracic surgery; veterinary cardiology; echocardiography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past decade, at the level of clinical practice and research in veterinary medicine, considerable attention has been given to diverse regenerative therapeutic modalities, particularly stem cells, extracellular vesicles, and platelet-derived products, which have provided potential cell and cell-free therapeutic choices to regenerate a wide range of animal tissues. Hence, they have been indicated in the treatment of various soft and hard tissue injuries, for instance, different kinds of wounds, corneal ulcers, and orthopedic and musculoskeletal conditions. Their exploitation in most animal species, such as canine, feline, equine, ovine, bovine, and porcine, has rendered their use highly promising and subject to further development. Recently, significant endeavors are being dedicated to reinforcing and broadening the scope of their employment in veterinary medicine.

This Special Issue’s objective is to present evidence-based methods for applying these regenerative treatments in the management of a range of illnesses in veterinary practice. It also emphasizes fresh viewpoints, innovative breakthroughs, present difficulties, most recent discoveries, latest advancements, and prospects in the field of veterinary regenerative medicine.

Dr. Hussein M. El-Husseiny
Prof. Dr. Ryou Tanaka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesenchymal stem cells 
  • exosomes 
  • platelet-rich concentrates 
  • regenerative medicine 
  • cell therapy 
  • cell-free therapy 
  • biomaterials 
  • soft and hard tissue engineering

Published Papers (4 papers)

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Review

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10 pages, 537 KiB  
Review
Use of Autologous Conditioned Serum (ACS) for Osteoarthritis Treatment in Horses: A Systematic Review of Clinical Data
by Simone Della Tommasa, Walter Brehm, Giacomo Farì, Andrea Bernetti and Annarita Imperante
Vet. Sci. 2023, 10(12), 707; https://doi.org/10.3390/vetsci10120707 - 18 Dec 2023
Viewed by 1603
Abstract
The utilization of Autologous Conditioned Serum (ACS) for treating osteoarthritis (OA) in horses has seen a notable increase in recent years. In vitro studies have consistently identified ACS as a promising therapy for OA joints, contributing to its growing popularity in OA treatment. [...] Read more.
The utilization of Autologous Conditioned Serum (ACS) for treating osteoarthritis (OA) in horses has seen a notable increase in recent years. In vitro studies have consistently identified ACS as a promising therapy for OA joints, contributing to its growing popularity in OA treatment. Despite this, there is a noticeable absence of systematic reviews focused solely on the clinical data of OA patients treated with ACS, excluding the in vitro perspective. This study aims to address this gap by systematically reviewing the latest literature, concentrating solely on clinical data in in vivo studies to evaluate the efficacy of ACS in OA lesions. All clinical studies involving ACS treatments for horses with OA were included in the assessment. Surprisingly, only six trials met the inclusion criteria for this systematic review. The results indicate that the majority of the considered articles support the use of ACS as a treatment for horses, albeit with a control group provided in only one study. However, the absence of a control group and the exclusion of histological evaluation diminish the validity of the majority of clinical research. While several studies suggest a beneficial effect of ACS on OA horses without significant adverse effects, this systematic review affirms that there is no definitive evidence for its effectiveness. Therefore, further investigation of the efficacy of ACS products as a treatment for OA is warranted, emphasizing the need for more controlled trials. Poorly designed and biased studies, lacking blinding or control and adopting inadequate outcome measures, may favor positive results and, thus, necessitate a more rigorous approach to validate the efficacy of ACS in OA treatment. Full article
(This article belongs to the Special Issue Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future Directions)
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18 pages, 733 KiB  
Review
Influence of the Anatomical Site on Adipose Tissue-Derived Stromal Cells’ Biological Profile and Osteogenic Potential in Companion Animals
by Carla Ferreira-Baptista, Rita Ferreira, Maria Helena Fernandes, Pedro Sousa Gomes and Bruno Colaço
Vet. Sci. 2023, 10(12), 673; https://doi.org/10.3390/vetsci10120673 - 24 Nov 2023
Viewed by 2764
Abstract
Adipose tissue-derived stromal cells (ADSCs) have generated considerable interest in the field of veterinary medicine, particularly for their potential in therapeutic strategies focused on bone regeneration. These cells possess unique biological characteristics, including their regenerative capacity and their ability to produce bioactive molecules. [...] Read more.
Adipose tissue-derived stromal cells (ADSCs) have generated considerable interest in the field of veterinary medicine, particularly for their potential in therapeutic strategies focused on bone regeneration. These cells possess unique biological characteristics, including their regenerative capacity and their ability to produce bioactive molecules. However, it is crucial to recognize that the characteristics of ADSCs can vary depending on the animal species and the site from which they are derived, such as the subcutaneous and visceral regions (SCAT and VAT, respectively). Thus, the present work aimed to comprehensively review the different traits of ADSCs isolated from diverse anatomical sites in companion animals, i.e., dogs, cats, and horses, in terms of immunophenotype, morphology, proliferation, and osteogenic differentiation potential. The findings indicate that the immunophenotype, proliferation, and osteogenic potential of ADSCs differ according to tissue origin and species. Generally, the proliferation rate is higher in VAT-derived ADSCs in dogs and horses, whereas in cats, the proliferation rate appears to be similar in both cells isolated from SCAT and VAT regions. In terms of osteogenic differentiation potential, VAT-derived ADSCs demonstrate the highest capability in cats, whereas SCAT-derived ADSCs exhibit superior potential in horses. Interestingly, in dogs, VAT-derived cells appear to have greater potential than those isolated from SCAT. Within the VAT, ADSCs derived from the falciform ligament and omentum show increased osteogenic potential, compared to cells isolated from other anatomical locations. Consequently, considering these disparities, optimizing isolation protocols becomes pivotal, tailoring them to the specific target species and therapeutic aims, and judiciously selecting the anatomical site for ADSC isolation. This approach holds promise to enhance the efficacy of ADSCs-based bone regenerative therapies. Full article
(This article belongs to the Special Issue Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future Directions)
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25 pages, 1093 KiB  
Review
The Pivotal Role of Stem Cells in Veterinary Regenerative Medicine and Tissue Engineering
by Hussein M. El-Husseiny, Eman A. Mady, Mahmoud A. Y. Helal and Ryou Tanaka
Vet. Sci. 2022, 9(11), 648; https://doi.org/10.3390/vetsci9110648 - 21 Nov 2022
Cited by 9 | Viewed by 3375
Abstract
The introduction of new regenerative therapeutic modalities in the veterinary practice has recently picked up a lot of interest. Stem cells are undifferentiated cells with a high capacity to self-renew and develop into tissue cells with specific roles. Hence, they are an effective [...] Read more.
The introduction of new regenerative therapeutic modalities in the veterinary practice has recently picked up a lot of interest. Stem cells are undifferentiated cells with a high capacity to self-renew and develop into tissue cells with specific roles. Hence, they are an effective therapeutic option to ameliorate the ability of the body to repair and engineer damaged tissues. Currently, based on their facile isolation and culture procedures and the absence of ethical concerns with their use, mesenchymal stem cells (MSCs) are the most promising stem cell type for therapeutic applications. They are becoming more and more well-known in veterinary medicine because of their exceptional immunomodulatory capabilities. However, their implementation on the clinical scale is still challenging. These limitations to their use in diverse affections in different animals drive the advancement of these therapies. In the present article, we discuss the ability of MSCs as a potent therapeutic modality for the engineering of different animals’ tissues including the heart, skin, digestive system (mouth, teeth, gastrointestinal tract, and liver), musculoskeletal system (tendons, ligaments, joints, muscles, and nerves), kidneys, respiratory system, and eyes based on the existing knowledge. Moreover, we highlighted the promises of the implementation of MSCs in clinical use in veterinary practice. Full article
(This article belongs to the Special Issue Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future Directions)
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15 pages, 1306 KiB  
Systematic Review
Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review
by Andrea Pérez Fraile, Elsa González-Cubero, Susana Martínez-Flórez, Elías R. Olivera and Vega Villar-Suárez
Vet. Sci. 2023, 10(12), 666; https://doi.org/10.3390/vetsci10120666 - 23 Nov 2023
Cited by 1 | Viewed by 1802
Abstract
Musculoskeletal injuries in horses have a great economic impact, predominantly affecting tendons, ligaments, and cartilage, which have limited natural regeneration. Cell therapy, which uses mesenchymal stem cells due to their tissue differentiation properties and anti-inflammatory and immunoregulatory effects, aims to restore damaged tissue. [...] Read more.
Musculoskeletal injuries in horses have a great economic impact, predominantly affecting tendons, ligaments, and cartilage, which have limited natural regeneration. Cell therapy, which uses mesenchymal stem cells due to their tissue differentiation properties and anti-inflammatory and immunoregulatory effects, aims to restore damaged tissue. In this manuscript, we performed a systematic review using the Parsifal tool, searching the PubMed and Web of Science databases for articles on regenerative medicine for equine musculoskeletal injuries. Our review covers 17 experimental clinical studies categorized by the therapeutic approach used: platelet-rich plasma, conditioned autologous serum, mesenchymal stem cells, and secretome. These therapies reduce healing time, promote regeneration of fibrocartilaginous tissue, improve cellular organization, and improve joint functionality and sustainability. In conclusion, regenerative therapies using platelet-rich plasma, conditioned autologous serum, equine mesenchymal stem cells, and the emerging field of the secretome represent a promising and highly effective approach for the treatment of joint pathologies in horses, implying a valuable advance in equine healthcare. Full article
(This article belongs to the Special Issue Regenerative Therapeutic Modalities in Veterinary Medicine: Current Status and Future Directions)
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