Chronic Infection by Oncogenic Viruses

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 15 September 2024 | Viewed by 1168

Special Issue Editor


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Guest Editor
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Center for Viral Oncology, Kansas City, KS, USA
Interests: HTLV-1; leukemia; oncogenesis; signal transduction pathways

Special Issue Information

Dear Colleague,

The study of oncogenic viruses has provided many basic insights into cancer, the most important of which is the identification and functional characterization of many oncogenes and tumor suppressor genes. In contrast to acute viruses, chronic viruses establish a persistent lifelong infection of their host. Chronic viral infections can be classified into different categories: Latent infections, characterized by minimal viral production during the initial and late stages. Productive infections, where persistent viral production occurs throughout the entire span, from initial infection to the late stages. Slow infections are marked by a gradual increase in viral production, starting from the incubation period and progressing to the late stages. The distinction among these stages is defined by the regulation of viral propagation and the alteration of viral gene expression patterns.

In this Special Issue, we will focus on the most recent advances in the understanding of the mechanisms of human oncogenic virus replication and pathogenesis. We will also focus on new developments in treatment, antiviral strategies, and vaccine development.

Prof. Dr. Christophe Nicot
Guest Editor

Manuscript Submission Information

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Keywords

  • virus transmission
  • virus replication
  • virus pathogenesis
  • virus latency
  • virus–host interactions
  • antiviral immune responses
  • virus-induced cellular transformation
  • antiviral drugs and vaccines

Published Papers (1 paper)

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Review

12 pages, 742 KiB  
Review
Human Papillomavirus and Associated Cancers: A Review
by JaNiese E. Jensen, Greta L. Becker, J. Brooks Jackson and Mary B. Rysavy
Viruses 2024, 16(5), 680; https://doi.org/10.3390/v16050680 - 26 Apr 2024
Viewed by 484
Abstract
The human papillomavirus is the most common sexually transmitted infection in the world. Most HPV infections clear spontaneously within 2 years of infection; however, persistent infection can result in a wide array of diseases, ranging from genital warts to cancer. Most cases of [...] Read more.
The human papillomavirus is the most common sexually transmitted infection in the world. Most HPV infections clear spontaneously within 2 years of infection; however, persistent infection can result in a wide array of diseases, ranging from genital warts to cancer. Most cases of cervical, anal, and oropharyngeal cancers are due to HPV infection, with cervical cancer being one of the leading causes of cancer death in women worldwide. Screening is available for HPV and cervical cancer, but is not available everywhere, particularly in lower-resource settings. HPV infection disproportionally affects individuals living with HIV, resulting in decreased clearance, increased development of cancer, and increased mortality. The development of the HPV vaccine has shown a drastic decrease in HPV-related diseases. The vaccine prevents cervical cancer with near 100% efficacy, if given prior to first sexual activity. Vaccination uptake remains low worldwide due to a lack of access and limited knowledge of HPV. Increasing awareness of HPV and access to vaccination are necessary to decrease cancer and HPV-related morbidity and mortality worldwide. Full article
(This article belongs to the Special Issue Chronic Infection by Oncogenic Viruses)
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