PANoptosis in Viral Infection

Dear Colleagues,

Innate immunity provides a critical first line of defence against infections, including viruses. The sensing of viruses by cytosolic innate immune sensors activates signalling pathways that can drive inflammatory cell death, as well as the production of antiviral interferons and proinflammatory cytokines. While inflammatory cell death can be beneficial to clear viral infections, it can also lead to excess inflammation and pathophysiology; therefore, the tight regulation of cell death in response to viral infections is critical.

This Special Issue on PANoptosis in viral infection focuses on viral sensing and the activation of PANoptosis, a unique, lytic, innate immune, and inflammatory cell death pathway that is driven by caspases as well as RIPKs and regulated by PANoptosome complexes. Multiple PANoptosomes have been identified in response to viral infection, including ZBP1- and AIM2-PANoptosomes. This collection of articles will discuss the cellular and molecular mechanisms of PANoptosis and PANoptosomes, providing new insights into therapeutic targets for antiviral therapies and strategies with which to mitigate immunopathogenesis.

Dr. Thirumala-Devi Kanneganti
Guest Editor

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