Topic Editors

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Instituto Politécnico de Bragança, Centro de Investigação de Montanha (CIMO), Campus Santa Apolonia, Braganca, Portugal
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal

Antioxidant Activity of Natural Products—2nd Edition

Abstract submission deadline
30 June 2025
Manuscript submission deadline
30 September 2025
Viewed by
4794

Topic Information

Dear Colleagues,

Natural products play an important role in the discovery and development of active ingredients with a wide range of applications. Its interest comes mainly from its antioxidant effects, which have been widely studied and pursued by researchers from different disciplines. Antioxidants can neutralize free radicals and reactive species, thereby counteracting oxidative damage, and, consequently, they are able to reduce the incidence of oxidative-stress-related diseases and interrupt free-radical-mediated chain reactions. This justifies their wide range of applications in medical and therapeutic goods, cosmetics, food additives, and biomaterials.

Natural products from different sources have been studied over the last decades, but much more remains to be discovered regarding the structural elucidation and mechanisms of the antioxidant action of their molecules. The discovery of new sources and compounds, more sustainable and selective extraction as well as isolation techniques, and more reliable as well as accurate analytical methods is still ongoing, as is the assessment of the role of antioxidants in human health and well-being. The development and standardization of model systems to accurately assess the biological or technological relevance of the antioxidant effect has been challenging but still necessary.

This transdisciplinary topic aims to bring together original research and review articles focusing on recent advances in the extraction, isolation, and characterization of plant-, fungal-, algal-, microbial-, and animal-derived antioxidants; the bioactivity, bioaccessibility, and bioavailability of antioxidants, as well as their interactions with other compounds; the molecular mechanisms of antioxidant action and their effects on particular metabolic or signaling pathways; the role of antioxidants in the prevention and treatment of health conditions; and the stabilization as well as application of antioxidants in foods, nutraceuticals, pharmaceuticals, and biomaterials. Other subjects related to this topic are also welcome.

Dr. José Pinela
Dr. Maria Inês Dias
Dr. Carla Pereira
Dr. Alexandra Plácido
Topic Editors

Keywords

  • secondary metabolites
  • natural antioxidants
  • in vitro, in vivo, and in silico models
  • structure–activity relationship
  • natural product chemistry
  • oxidative stress and antioxidant defense
  • free-radical-mediated chain reactions
  • extraction and separation methods
  • antioxidant ingredients and biomaterials

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomolecules
biomolecules
4.8 9.4 2011 16.3 Days CHF 2700 Submit
International Journal of Molecular Sciences
ijms
4.9 8.1 2000 18.1 Days CHF 2900 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit
Scientia Pharmaceutica
scipharm
2.3 4.6 1930 31.4 Days CHF 1000 Submit
Marine Drugs
marinedrugs
4.9 9.6 2003 12.9 Days CHF 2900 Submit
Plants
plants
4.0 6.5 2012 18.2 Days CHF 2700 Submit

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Published Papers (3 papers)

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20 pages, 3716 KiB  
Article
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin
by Qiyuan Wang, Aike Li, Hao Yu, Chuanqi Wang, Ting Wang and Jing Zhang
Int. J. Mol. Sci. 2024, 25(13), 6984; https://doi.org/10.3390/ijms25136984 - 26 Jun 2024
Viewed by 1108
Abstract
Deoxynivalenol (DON) is a mycotoxin produced by Fusarium graminearum, and curcumin (CUR) is a natural polyphenolic compound found in turmeric. However, the combined treatment of CUR and DON to explore the mitigating effect of CUR on DON and their combined mechanism of [...] Read more.
Deoxynivalenol (DON) is a mycotoxin produced by Fusarium graminearum, and curcumin (CUR) is a natural polyphenolic compound found in turmeric. However, the combined treatment of CUR and DON to explore the mitigating effect of CUR on DON and their combined mechanism of action is not clear. Therefore, in this study, we established four treatment groups (CON, CUR, DON and CUR + DON) to investigate their mechanism in the porcine intestinal epithelial cells (IPEC-J2). In addition, the cross-talk and alleviating potential of CUR interfering with DON-induced cytotoxic factors were evaluated by in vitro experiments; the results showed that CUR could effectively inhibit DON-exposed activated TNF-α/NF-κB pathway, attenuate DON-induced apoptosis, and alleviate DON-induced endoplasmic reticulum stress and oxidative stress through PERK/CHOP pathways, which were verified at both mRNA and protein levels. In conclusion, these promising findings may contribute to the future use of CUR as a novel feed additive to protect livestock from the harmful effects of DON. Full article
(This article belongs to the Topic Antioxidant Activity of Natural Products—2nd Edition)
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21 pages, 27387 KiB  
Article
Physicochemical Characterization, Antioxidant and Anticancer Activity Evaluation of an Acidic Polysaccharide from Alpinia officinarum Hance
by Huan Wen, Yangjun Kuang, Xiuxia Lian, Hailong Li, Mingyan Zhou, Yinfeng Tan, Xuguang Zhang, Yipeng Pan, Junqing Zhang and Jian Xu
Molecules 2024, 29(8), 1810; https://doi.org/10.3390/molecules29081810 - 16 Apr 2024
Cited by 5 | Viewed by 1173
Abstract
AHP-3a, a triple-helix acidic polysaccharide isolated from Alpinia officinarum Hance, was evaluated for its anticancer and antioxidant activities. The physicochemical properties and structure of AHP-3a were investigated through gel permeation chromatography, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and nuclear magnetic resonance [...] Read more.
AHP-3a, a triple-helix acidic polysaccharide isolated from Alpinia officinarum Hance, was evaluated for its anticancer and antioxidant activities. The physicochemical properties and structure of AHP-3a were investigated through gel permeation chromatography, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. The weight-average molecular weight of AHP-3a was 484 kDa, with the molar percentages of GalA, Gal, Ara, Xyl, Rha, Glc, GlcA, and Fuc being 35.4%, 21.4%, 16.9%, 11.8%, 8.9%, 3.1%, 2.0%, and 0.5%, respectively. Based on the results of the monosaccharide composition analysis, methylation analysis, and NMR spectroscopy, the main chain of AHP-3a was presumed to consist of (1→4)-α-D-GalpA and (1→2)-α-L-Rhap residues, which is a pectic polysaccharide with homogalacturonan (HG) and rhamnogalacturonan-I (RG-I) structural domains containing side chains. In addition, the results of the antioxidant activity assay revealed that the ability of AHP-3a to scavenge DPPH, ABTS, and OH free radicals increased with an increase in its concentration. Moreover, according to the results from the EdU, wound healing, and Transwell assays, AHP-3a can control the proliferation, migration, and invasion of HepG2 and Huh7 hepatocellular carcinoma cells without causing any damage to healthy cells. Thus, AHP-3a may be a natural antioxidant and anticancer component. Full article
(This article belongs to the Topic Antioxidant Activity of Natural Products—2nd Edition)
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12 pages, 6658 KiB  
Article
Tangeretin Mitigates Trimethylamine Oxide Induced Arterial Inflammation by Disrupting Choline–Trimethylamine Conversion through Specific Manipulation of Intestinal Microflora
by Yu Cao, Changlong Leng, Kuan Lin, Youwei Li, Meiling Zhou, Mei Zhou, Xiji Shu and Wei Liu
Molecules 2024, 29(6), 1323; https://doi.org/10.3390/molecules29061323 - 16 Mar 2024
Viewed by 1125
Abstract
Previous studies have revealed the microbial metabolism of dietary choline in the gut, leading to its conversion into trimethylamine (TMA). Polymethoxyflavones (PMFs), exemplified by tangeretin, have shown efficacy in mitigating choline-induced cardiovascular inflammation. However, the specific mechanism by which these compounds exert their [...] Read more.
Previous studies have revealed the microbial metabolism of dietary choline in the gut, leading to its conversion into trimethylamine (TMA). Polymethoxyflavones (PMFs), exemplified by tangeretin, have shown efficacy in mitigating choline-induced cardiovascular inflammation. However, the specific mechanism by which these compounds exert their effects, particularly in modulating the gut microbiota, remains uncertain. This investigation focused on tangeretin, a representative PMFs, to explore its influence on the gut microbiota and the choline–TMA conversion process. Experimental results showed that tangeretin treatment significantly attenuated the population of CutC–active bacteria, particularly Clostridiaceae and Lactobacillus, induced by choline chloride in rat models. This inhibition led to a decreased efficiency in choline conversion to TMA, thereby ameliorating cardiovascular inflammation resulting from prolonged choline consumption. In conclusion, tangeretin’s preventive effect against cardiovascular inflammation is intricately linked to its targeted modulation of TMA–producing bacterial activity. Full article
(This article belongs to the Topic Antioxidant Activity of Natural Products—2nd Edition)
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