Individualized Molecular Mechanisms and Treatment in Tumor Metastasis

Dear Colleagues,

The purpose and scope of tumor metastasis are still a challenge for personalized tumor therapy and an important reason for the poor prognosis of tumor patients. In recent years, researchers have attempted to apply genomics, transcriptomic, and proteomic techniques to establish reasonably stable animal tumor metastasis models to explore the internal tumor microenvironment and molecular mechanisms during the process of metastasis and subsequently study the potential drug targets in metastatic tumors. However, even the metastatic process of a specific tumor has individual characteristics. With the progress of research in this field, more and more mechanisms related to the metastatic process have been reported, such as exosomes, the tumor metabolism, etc. Therefore, the complexity of tumor metastasis brings difficulties and challenges, and more advanced research is urgently needed. This Special Collection aims to collect recent advances in the pathogenesis and treatment strategies of metastatic neoplastic processes. Potential submissions include but are not limited to:

• The latest research on the process of tumor metastasis, such as vascular invasion, pre-metastatic niche formation, engraftment of metastases, and resistance to anoikis;
• The latest research on the role of the tumor microenvironment in tumor metastasis, including the interaction of tumor cells and non-tumor cells, spatiotemporal changes of the tumor microenvironment, multi-omics-based exploration of the tumor microenvironment, and drug resistance in metastatic tumors.

Dr. Dong Tang
Dr. Chen Liu
Prof. Dr. Bin Cheng
Topic Editors