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Article

A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties

by
Xufei Bian
1,†,
Lan Jiang
2,†,
Zongjie Gan
1,
Xiaoshu Guan
1,
Li Zhang
1,
Linhong Cai
1 and
Xiangnan Hu
1,*
1
Department of Medicinal Chemistry, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China
2
College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400016, China
*
Author to whom correspondence should be addressed.
†
LAN JIANG is co-first author, supervised by Xufei Bian.
Molecules 2019, 24(20), 3786; https://doi.org/10.3390/molecules24203786
Submission received: 24 September 2019 / Revised: 13 October 2019 / Accepted: 18 October 2019 / Published: 21 October 2019
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure analysis. The results showed an enhancement of the pharmaceutical properties such as lower hygroscopicity and greater accelerated stability than the parent drug Met, and a higher solubility and dissolution rate than Gli.
Keywords: Glimepiride; metformin; dissolution; hygroscopicity Glimepiride; metformin; dissolution; hygroscopicity

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MDPI and ACS Style

Bian, X.; Jiang, L.; Gan, Z.; Guan, X.; Zhang, L.; Cai, L.; Hu, X. A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties. Molecules 2019, 24, 3786. https://doi.org/10.3390/molecules24203786

AMA Style

Bian X, Jiang L, Gan Z, Guan X, Zhang L, Cai L, Hu X. A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties. Molecules. 2019; 24(20):3786. https://doi.org/10.3390/molecules24203786

Chicago/Turabian Style

Bian, Xufei, Lan Jiang, Zongjie Gan, Xiaoshu Guan, Li Zhang, Linhong Cai, and Xiangnan Hu. 2019. "A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties" Molecules 24, no. 20: 3786. https://doi.org/10.3390/molecules24203786

APA Style

Bian, X., Jiang, L., Gan, Z., Guan, X., Zhang, L., Cai, L., & Hu, X. (2019). A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties. Molecules, 24(20), 3786. https://doi.org/10.3390/molecules24203786

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